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Target Therapy for Hepatocellular Carcinoma

Yoon SK

Hepatocellular carcinoma (HCC) is a highly malignant tumor that has limited treatment options in its advanced state. The efficacy of current anti-cancer chemotherapy in advanced HCC has not been satisfactory,...
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Targeted Therapy for Breast Cancer

Oh HS

Breast cancer is the most common cancer in women in the U.S. and Western Europe and second most common cancer in women in Korea. Targeted therapies for breast cancer are...
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Development of Tyrosine Kinase Inhibitor in Chronic Myeloid Leukemia

Kim H

Chronic myeloid leukemia (CML) is a malignant disease induced by the oncogenic signal of the BCRABL transcript resulting from the translocation between chromosome 9 and 22, t (9:22). This genetic...
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Targeted Therapy in Inflammatory Bowel Disease; Current Status and Future Perspectives

Jang BI

Novel biologic agents that selectively target specific molecules and pathways have been developed recently for the management of inflammatory bowel disease (IBD). Anti-TNF-alpha, an antibody to TNF-alpha is one of...
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Novel Pharmacologic Therapies in the Treatment of Systemic Lupus Erythematosus

Shim SC

Systemic lupus erythematosus (lupus) is an autoimmune disease that affects primarily women, especially those of reproductive age. Lupus is a prototypic organ non-specific autoimmune disease that may affect any organ...
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Tailored Treatment of Ankylosing Spondylitis

Kim TJ

Ankylosing spondylitis (AS) is a chronic rheumatic disease of the axial skeleton (spine and sacroiliac joints). Only nonsteroidal anti-inflammatory drugs (NSAIDs) and tumor necrosis factor (TNF) alpha inhibitors have currently...
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Biologic Agent for Rheumatoid Arthritis

Park SH, Kim SK, Choe JY

Decades of accumulated knowledge and improved comprehension of various perspectives on rheumatoid arthritis (RA) pathophysiology has led to the development of new biologic agents that inhibit a specific component of...
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The Role of Genetics in Predictive and Personalized Medicine of Rheumatoid Arthritis

Lee HS

Recent progress of genetics has dramatically improved pharmacogenetics for human diseases. Several pharmacogenetic assays such as TPMT/azathioprine and CYP2C9/VKORC1/warfarin have been introduced in clinical practice at the present time. Rheumatoid...
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