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Role of Sigma Receptor and Neurosteroids in Pain Sensation

Lee JH

The sigma-1 receptor has recently been implicated in a myriad of cellular functions and biological processes. Previous studies have demonstrated that the spinal sigma-1 receptor plays a pro-nociceptive role in...
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The Role of Transient Receptor Potential Channel in Pain

Jung SJ

Transient receptor potential (TRP) channels, a large family of receptor channel proteins, initially attracted researchers in the pain field as key molecules in nociception, but later they became known as...
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Animal Models for Orofacial Neuropathic Pain

Ahn DK, Park MK

Orofacial neuropathic pain is initiated by extraction of teeth or nerve injury from trauma in the trigeminal nerve that innervates the facial area. In the experiment, orofacial neuropathic pain usually...
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Animal Pain Models and Behavior Tests

Park JY

Animal pain models are essential for understanding the mechanism of pain and development of effective therapy for its management. Various animal pain models have been developed to simulate the clinical...
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Lumbar Ventral Epidural Approach

Shim JC

The utilization of transforaminal epidural steroid injections (TFESIs), an elective diagnostic and therapeutic spinal procedure, has risen dramatically over the past decade. The transforaminal technique uses a needle that approaches...
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Spinal Cord Stimulation for Control of Chronic Pain

Kim YS

Spinal cord stimulation (SCS) has undergone a variety of technical modifications and advances and has been applied to a variety of pain conditions. The group of patients in which SCS...
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Diagnosis and Treatment of Complex Regional Pain Syndrome

Shin JW

Complex regional pain syndromes (CRPS) are neuropathic pain disorders of one or more extremities developing inadequately after trauma or lesions in the peripheral or central nervous system (CNS). However, CRPS...
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Opioid Therapy for Chronic Nonmaliganat Pain

Lee YW

While acute pain is reasonably considered a symptom of disease or injury, chronic pain is a specific healthcare related problem as a disease in its own right. Even though the...
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Trigeminal Neuralgia and Neural Blockade

Shin KM

Trigeminal neuralgia is characterized by recurrent episodes of intense lancinating pain affecting the face localized to the sensory supply areas of the trigeminal nerve. There is a lack of certainty...
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Clinical Application of alpha2-delta Ligand

Shim JH

Chronic pathological pain is sustained by mechanisms of peripheral and central sensitization, which are being increasingly investigated at the molecular and cellular levels. The molecular mechanisms of sensitization that occur...
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