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Volatile General Anesthetics and Tandem Pore Domain K+ Channel

Shin WJ

  • KMID: 1482465
  • Hanyang Med Rev.
  • 2008 Nov;28(4):63-72.
Two-pore domain K+ (K2P) channels are recently described. They have properties of background K+ channels, and play a crucial role in setting the resting membrane potential and regulating cell excitability....
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General Anesthetics and Single-Channel Recording

Kim KH, Shin WJ

  • KMID: 1482464
  • Hanyang Med Rev.
  • 2008 Nov;28(4):53-62.
Introduction of patch-clamp techniques allowed an increase in resolution of membrane current recordings. However, the technique was limited by apparent need for direct contact of pipette with cell membrane. Thus,...
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Calcium channels

Lee W

  • KMID: 1482463
  • Hanyang Med Rev.
  • 2008 Nov;28(4):48-52.
Calcium channels are ion channels formed by membrane spanning proteins that have a calciumselective pore. There are some types of calcium channels. One type is calcium channel whose gating is...
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The glycine receptor

Park HJ

  • KMID: 1482462
  • Hanyang Med Rev.
  • 2008 Nov;28(4):40-47.
The glycine receptor (GlyR), a member of the pentameric ligand gated ion channel family, is best known for mediating inhibitory neurotransmission in motor and sensory circuits of the spinal cord, and...
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Anesthesia and sodium channel

Kim HJ

  • KMID: 1482461
  • Hanyang Med Rev.
  • 2008 Nov;28(4):36-39.
Voltage-gated sodium channels are large glycoproteins that permit selective sodium ion conduction in excitable cells such as neurons. They generate upstroke of action potential and transmit depolarizing impulses through the...
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K+ channel

Kim HS

  • KMID: 1482460
  • Hanyang Med Rev.
  • 2008 Nov;28(4):32-35.
Potassium-selective channels are the largest and most diverse group of ion channels in the human. Also, potassium-selective channels are important in many cells during anesthesia. Many researches have focused on...
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Anethesia and Glutamate Receptors

Do SH

  • KMID: 1482459
  • Hanyang Med Rev.
  • 2008 Nov;28(4):28-31.
Glutamate receptors represent major excitatory neurotransmission. Besides anesthesia, pain, memory and learning and neurotoxicity (excitotoxicity)are closely associated with the glutamate receptor, especially the NMDA receptor. Ketamine, an NMDA receptor antagonist,...
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NMDA receptor channel

Lee IO

  • KMID: 1482458
  • Hanyang Med Rev.
  • 2008 Nov;28(4):17-27.
Glutamate receptor channels have been classified into three major subtypes, the alpha-amino-3 - hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainite and N-Methyl-D-aspartate (NMDA) receptor channels. The NMDA receptor channel differs in fundamental...
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K(ATP) channel

Hong DM

  • KMID: 1482457
  • Hanyang Med Rev.
  • 2008 Nov;28(4):11-16.
Pharmacological preconditioning with volatile anesthetics is a phenomenon whereby a brief exposure to volatile anesthetic agents protects the heart from the potentially fatal consequences of a subsequent prolonged period of...
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The properties of voltage-sensitive chloride channels

Jung SJ

  • KMID: 1482456
  • Hanyang Med Rev.
  • 2008 Nov;28(4):4-10.
Chloride (Cl) channels are probably found in every cell, from bacteria to mammals. Cl channels are distributed both in the plasma membrane and in intracellular organelles. Three well established structural...
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