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Etoposide-induced Smad6 expression is required for the G1 to S phase transition of the cell cycle in CMT-93 mouse intestinal epithelial cells

Lee YS, Lee EK, Han IO, Park SH

The inhibitory Smad6 and Smad7 are responsible for cross-talk between TGF-beta/bone morphogenic protein (BMP) signaling and other cellular signaling pathways, as well as negative feedback on their own signaling functions....
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Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells

Lee E, Choi MK, Han IO, Lim SJ

  • KMID: 1094159
  • Exp Mol Med.
  • 2006 Jun;38(3):325-331.
SC-560, a strucutral analogue of celecoxib, induces growth inhibition in a wide range of human cancer cells in a cyclooxygenase (COX)-independent manner. Since SC-560 suppresses the growth of cancer cells...
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