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Diverse Effects of Small Molecule Inhibitors on Actin Cytoskeleton Dynamics in HIV-1 Infection

Shin Y, Choi BS, Kim KC, Kim K, Yoon CH

The dynamics of the actin cytoskeleton plays a pivotal role in the process of cell division, the transportation of organelles, vesicle trafficking and cell movement. Human immunodeficiency virus type 1...
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Safety and Effectiveness Analysis of Kivexa® (lamivudine/abacavir sulfate) in Human Immunodeficiency Virus Infected Korean Patients

Ann H, Lee YS, Kim YS, Jung SI, Lee SH, Lee CS, Lee JS, Choi WS, Choi YH, Kim SW

BACKGROUND: Lamivudine and abacavir sulfate are widely used nucleoside/tide reverse transcriptase inhibitors (NRTI) backbone agents, which are recommended in major international treatment guidelines. The fixed-dose combination of lamivudine and abacavir...
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Long-Term Stability of HBV, HCV, and HIV-1 National Reference Standards for in vitro Diagnostic Medical Devices Intended to Be Used for the Nucleic Acid Amplification Test

Choi KY, Youn KW, Cha YJ, Min HK, Kim J

BACKGROUND: National reference standards are essential to the quality assessment and regulatory approval of in vitro diagnostic medical devices. However, the long-term stability of national reference standards has not been...
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Monomorphic ventricular tachycardia due to protease inhibitor intoxication by atazanavir

Kim B, Kim KS

Atazanavir is a protease inhibitor approved for use in combination with other antiretroviral drugs for the treatment of human immunodeficiency virus infection. Atazanavir and other protease inhibitors can sometimes induce...
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Safety and Efficacy of Ziagen (Abacavir Sulfate) in HIV-Infected Korean Patients

Ann H, Kim KH, Choi HY, Chang HH, Han SH, Kim KH, Lee JS, Kim YS, Park KH, Kim YK, Sohn JW, Yun NR, Lee CS, Choi YW, Lee YS, Kim SW

BACKGROUND: Abacavir is a widely-used nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus (HIV) infection. Mandatory postmarketing surveillance was conducted in Korea to monitor the safety and...
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Change in Renal Function among HIV-Infected Koreans Receiving Tenofovir Disoproxil Fumarate-Backbone Antiretroviral Therapy: A 3-Year Follow-Up Study

Lee KH, Lee JU, Ku NS, Jeong SJ, Han SH, Choi JY, Song YG, Kim JM

PURPOSE: Tenofovir disoproxil fumarate (TDF) is commonly prescribed as a fixed-dose, co-formulated antiretroviral drug for HIV-1 infection. The major concern of long-term TDF use is renal dysfunction. However, little is...
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Efficacy and Safety of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate in Asian Subjects with Human Immunodeficiency Virus 1 Infection: A Sub-Analysis of Phase 3 Clinical Trials

Choi JY, Sungkanuparph S, Anekthananon T, Sax P, DeJesus E, Edelstein , Nelson M, DeMorin J, Liu HC, Swamy R, Bahn J, Hwang S, Yang SY, Ng C, Piontkowsky D

The efficacy and safety of a single tablet regimen (STR) of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (E/C/F/TDF) were analyzed in Phase 3 clinical trials in antiretroviral therapy (ART)-naïve and ART-experienced Asian subjects...
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Cytotoxic Effects of Gallic Acid and its Derivatives Against HIV-I-infected Microglia

Jeong JJ, Lee YS, Kim DH

In the previous study, we found that flavonoids and ginsenosides exhibited high eliminate rates of human immunodeficiency virus type 1 (HIV-1) D3-transfected macrophages. Based on these findings, here we synthesized...
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High yields and soluble expression of superoxide dismutases in Escherichia coli due to the HIV-1 Tat peptide via increases in mRNA transcription

Sun Y, Ye Q, Wu M, Wu Y, Zhang C, Yan W

This study aimed to validate the high yield and soluble expression of proteins carrying the transactivator of transcription (Tat) peptide tag, and further explored the potential mechanism by which the...
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Recent update in HIV vaccine development

Shin SY

Despite the tremendous efforts to develop a successful human immunodeficiency virus (HIV) vaccine, the quest for a safe and effective HIV vaccine seems to be remarkably long and winding. Disappointing...
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The CD4 slope can be a predictor of immunologic recovery in advanced HIV patients: a case-control study

Kim KH, Yi J, Lee SH

BACKGROUND/AIMS: Advanced human immunodeficiency virus (HIV) infection, despite sustained viral suppression by highly active antiretroviral therapy (HAART), is a risk factor for poor immunologic recovery. However, some patients with advanced...
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Performance of the Elecsys HIV combi PT Assay Compared to the ARCHITECT HIV Ag/Ab Combo Assay

Jung BK, Kim HN, Choi JS, Shin K, Lee CK, Cho Y

BACKGROUND: The aim of this study was to compare the analytical sensitivity and specificity of the recently updated 4th generation Elecsys HIV combi PT assay (Roche Diagnostics GmbH, Germany) to...
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HIV-1 Tat Protein Promotes Amyloid beta Generation and Tau Phosphorylation in Rat Hippocampal Slices

Lee EO, Jhang KA, An YW, Ju W, Chong YH

HIV-1 Tat protein has been implicated as a causative agent in the pathogenesis of HIV-1-associated neurocognitive disorder (HAND) and Alzheimer's disease (AD)-like pathology in HIV-1 infected patients. Here, we provide...
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Human Immunodeficiency Virus Type 1 Tat-Mediated Cellular Response in Myeloid Cells

Kim NY, Kim YW

Human immunodeficiency virus type 1 (HIV-1)-infected cells respond to the infection with different outcomes depending on their cell type. The interplay of cellular and viral proteins is a key player...
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Characterization of Gp41 Polymorphisms in the Fusion Peptide Domain and T-20 (Enfuvirtide) Resistance-Associated Regions in Korean HIV-1 Isolates

Jang DH, Yoon CH, Choi BS, Chung YS, Kim HY, Chi SG, Kim SS

HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutation of gp41 affects HIV-1 entry and susceptibility to the fusion inhibitor T-20. Therefore, we...
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Human Papillomavirus Prevalence and Genotype Distribution among HIV-Infected Women in Korea

Park EK, Cho H, Lee SH, Lee SG, Lee SY, Kim KH, Lee CH, Chung JS, Kwak IS

The epidemiology on human papillomavirus (HPV) among human immunodeficiency virus (HIV)-infected women in Korea is not well established. A retrospective study was conducted to determine the prevalence and genotype distribution...
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HIV-1 Tat Protein-dependent Cytotoxicity is Attenated by 15-deoxy-Delta12,14-Prostaglandin J2 in Rat Hippocampal Slices: Involvement of the ERK1/2 Signaling Pathway

Lee EO, Yang JH, Kim JH, Woo SY, Chong YH

15-deoxy-delta12,14 prostaglandin J2 (15d-PGJ2) may hold promise in treatment of the pathologies associated with human immunodeficiency virus (HIV) infection of the central nervous system. However, its precise role and neuroprotective...
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Analysis for Human Immunodeficiency Virus 1 Subtype in Korean Blood Donors

Cho YJ, Kim MH, Kwon SY, Cho NS, Yoon KW, Jee YH, Choi KY

  • KMID: 1424272
  • Korean J Blood Transfus.
  • 2012 Dec;23(3):210-216.
BACKGROUND: Genetic variants of virus appear to differ depending on the country, race, infection route, and so on. To characterize the main HIV subtype in infected blood donors and inquire...
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Immunohistochemical Study of the Expression of Astrocyte Elevated Gene-1 (AEG-1) in Malignant Melanoma, Spitz Nevus and Dysplastic Nevus

Kim BC, Seung NR, Park EJ, Kwon IH, Kim KH, Kim KJ, Park HR

  • KMID: 2247588
  • Korean J Dermatol.
  • 2011 Apr;49(4):334-338.
BACKGROUND: The astrocyte elevated gene-1 (AEG-1) was cloned as a novel HIV-1 and tumor necrosis factor-alpha-induced transcript from primary human fetal astrocytes. It has been reported that the AEG-1 expression...
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Efficiency of Recombinant Bacille Calmette-Guerin in Inducing Humoral and Cell Mediated Immunities against Human Immunodeficiency Virus Type 1 Third Variable Domain in Immunized Mice

Kim YJ

PURPOSE: The third variable (V3) loop of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein has been intensively studied for AIDS vaccine development. Bacille Calmette-Guerin (BCG) is widely used...
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