- Characterization of Gp41 Polymorphisms in the Fusion Peptide Domain and T-20 (Enfuvirtide) Resistance-Associated Regions in Korean HIV-1 Isolates
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Jang DH, Yoon CH, Choi BS, Chung YS, Kim HY, Chi SG, Kim SS
- KMID: 1734938
- J Korean Med Sci.
- 2014 Mar;29(3):456-459.
- doi: 10.3346/jkms.2014.29.3.456
HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutation of gp41 affects HIV-1 entry and susceptibility to the fusion inhibitor T-20. Therefore, we... -
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- Structure-activity relationships of anti-HIV-1 peptides with disulfide linkage between D- and L-cysteine at positions i and i+3, respectively, derived from HIV-1 gp41 C-peptide
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Lee MK, Kim HK, Lee TY, Hahm KS, Kim KL
- KMID: 1105273
- Exp Mol Med.
- 2006 Feb;38(1):18-26.
The constrained alpha-helical structure of a C-peptide is useful for enhancing anti-HIV-1 activity. The i and i+3 positions in an alpha-helical structure are located close together, therefore D-Cys (dC) and... -
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