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Gut Microbiota Involved in the Immunopathogenesis of Autoimmune Pancreatitis

Minaga K, Watanabe T, Hara A, Yoshikawa T, Kamata K, Kudo M

Autoimmune pancreatitis (AIP), which is considered the pancreatic expression of a systemic immunoglobulin G4-related disease, is characterized by excessive infiltration of plasmacytes bearing immunoglobulin G4 and a unique form of...
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Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and Hepatologists

Han JW, Shin EC

Liver tissue-resident memory T (TRM ) cells play a pivotal role in hepatic immune responses. Their unique residence within liver sinusoids allow continuous antigen surveillance. In this review, we highlight the role...
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Effect of Probiotics on Improving Intestinal Mucosal Permeability and Inflammation after Surgery

Kim MJ, Lee YJ, Hussain Z, Park H

Background/Aims: We explored the mechanisms underlying the improvement of postoperative ileus (POI) following probiotic pretreatment. We assessed intestinal permeability, inflammation, tight junction (TJ) protein expression in the gut epithelium, and...
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Assessing the Validity of the AASLD Surgical Treatment Algorithm in Patients with Early-Stage Hepatocellular Carcinoma

Kim A, Song BG, Kang W, Gwak GY, Paik YH, Choi MS, Lee JH, Goh MJ, Sinn DH

Background/Aims: The aim of this study was to investigate the effect of a surgical treatment algorithm recently proposed by the American Association for the Study of Liver Diseases (AASLD) on...
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Membranous Overexpression of Fibronectin Predicts Microvascular Invasion and Poor Survival Outcomes in Patients with Hepatocellular Carcinoma

Hwang YJ, Lee H, Hong SK, Yu SJ, Kim H

Background/Aims: Fibronectin (FN) has recently been identified as being overexpressed in patients with hepatocellular carcinoma (HCC) and deemed a promising biomarker of vascular invasion. The aim of this study was...
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Endoscopic Treatment of Gastric Neuroendocrine Tumors: What’s Next?

Kim I, Cho YK

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What Is the Easiest Way to Diagnose Advanced-Stage Autoimmune Gastritis in the Korean Context?

Lee SY

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Long-term Outcomes of Endoscopic Radiofrequency Ablation versus Endoscopic Submucosal Dissection for Widespread Superficial Esophageal Squamous Cell Neoplasia

Tang X, Meng QQ, Gao Y, Yu CT, Zhang YR, Bian Y, Xu JF, Xin L, Wang W, Lin H, Wang LW

Background/Aims: Endoscopic radiofrequency ablation (ERFA) is a treatment option for superficial esophageal squamous cell neoplasia (ESCN), with a relatively low risk of stenosis; however, the long-term outcomes remain unclear. We...
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Advancements in Endoscopic Treatment for Gastric Subepithelial Tumors

Goto O, Higuchi K, Koizumi E, Iwakiri K

Peroral flexible endoscopy is a minimally invasive technique that enables the local resection of gastric subepithelial tumors (SETs) with malignant potential. Resection techniques are mainly chosen on the basis of...
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Risk of Lower Gastrointestinal Bleeding in Nonsteroidal Anti-inflammatory Drug (NSAID) and Proton Pump Inhibitor Users Compared with NSAID-Only Users: A Common Data Model Analysis

Lee M, Kim M, Cha JM

Background/Aims: Recent studies have shown an increased risk of lower gastrointestinal bleeding in patients who use both nonsteroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs). We analyzed the risk...
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Clinical Characteristics and Long-term Outcomes of Gastric Neuroendocrine Tumors

Zheng Q, Kim JY, Cho SJ, Kim SG, Chung H

Background/Aims: Gastric neuroendocrine tumors (GNETs), once rare, have become more prevalent due to the increased use of endoscopy and increased physician awareness. The clinical characteristics and long-term outcomes of GNET...
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Association between Gamma-Glutamyl Transferase Levels and Pancreatobiliary Cancer Risk in Patients with Diabetes: Evidence from the National Health Insurance Cooperation Health Checkup 2009 to 2012

Heo JH, Kang JG, Han K, Lee KJ

Background/Aims: Elevated gamma-glutamyl transferase (GGT) levels indicate hepatic dysfunction and have been linked to an increased risk of pancreatobiliary cancers. However, this association, particularly in individuals with diabetes mellitus (DM),...
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The Long Noncoding RNA DUXAP8 Facilitates the Malignant Progression of Colon Cancer via the microRNA-378a-3p/FOXQ1 Axis

Shang R, Jin J, Wang Y

Background/Aims: The long noncoding RNA DUXAP8 is a pivotal regulator in cancer pathogenesis, but the molecular mechanism underlying the role of DUXAP8 in colon cancer progression is underexplored. Methods: In addition...
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Anxiety and Depression Are Associated with Poor Long-term Quality of Life in Moderate-to-Severe Ulcerative Colitis: Results of a 3-Year Longitudinal Study of the MOSAIK Cohort

Oh SJ, Choi CH, Jung SA, Song GA, Kim YJ, Koo JS, Shin SJ, Seo GS, Lee KM, Jang BI, Jung ES, Kim Y, Lee CK

Background/Aims: We previously reported that patients with moderate-to-severe ulcerative colitis (UC) often experience common mental disorders (CMDs) such as anxiety and depression, necessitating immediate psychological interventions within the first 4...
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Trends and Factors Related to Quality of Life in Patients with Inflammatory Bowel Disease

Kim S, Jun YK, Choi Y, Shin CM, Park YS, Kim N, Lee DH, Yoon H

Background/Aims: Inflammatory bowel disease (IBD) affects health-related quality of life (HRQoL). The Short Inflammatory Bowel Disease Questionnaire (SIBDQ) score is strongly correlated with HRQoL in IBD patients. This study aimed...
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Autoimmune Gastritis in Korean Patients with Gastric Tumors: Clinicopathologic Correlations and Diagnostic Histological Features

Ahn S, Kim TS, Kushima R, Lee JH, Kim KM

Background/Aims: Autoimmune gastritis (AIG) is a corpus-dominant atrophic gastritis in which patients are positive for antiparietal cell antibody (APCA) and/or anti-intrinsic factor antibody. The risk of developing gastric cancer in...
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