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A Biomechanical Comparison of 2 Different Topping-off Devices and Their Influence on the Sacroiliac Joint Following Lumbosacral Fusion Surgery

Fan W, Yang S, Chen J, Guo LX, Zhang M

Objective: Interspinous spacer (ISS)-based and pedicle screw-rod dynamic fixator (PDF)-based topping-off devices have been applied in lumbar/lumbosacral fusion surgeries for preventing the development of proximal adjacent segment degeneration. However, little...
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Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect

Chang XM, Xiao F, Pan Q, Wang XX, Guo LX

Although the contributions of sitagliptin to endothelial dysfunction in diabetes mellitus were previously reported, the mechanisms still undefined. Autophagy plays an important role in the development of diabetes mellitus, but...
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