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Search for "Proximal Histidine" of Thyroperoxidase Using Site Directed Mutagenesis

Kim WB, Shong YK

  • KMID: 2200381
  • J Korean Soc Endocrinol.
  • 2003 Aug;18(4):371-378.
BACKGROUND: Thyroperoxidase (TPO), a transmembrane heme containing glycoprotein, catalyzes iodide organification and thyroid hormone synthesis. It is a single peptide making a loop with more than one disulfide bond. The...
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