- Fasiglifam (TAK-875), a G Protein-Coupled Receptor 40 (GPR40) Agonist, May Induce Hepatotoxicity through Reactive Oxygen Species Generation in a GPR40-Dependent Manner
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Kim M, Gu GJ, Koh YS, Lee SH, Na YR, Seok SH, Lim KM
- KMID: 2427514
- Biomol Ther.
- 2018 Nov;26(6):599-607.
- doi: 10.4062/biomolther.2017.225
Fasiglifam (TAK-875) a G-protein coupled receptor 40 (GPR40) agonist, significantly improves hyperglycemia without hypoglycemia and weight gain, the major side effects of conventional anti-diabetics. Unfortunately, during multi-center Phase 3 clinical... -
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