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Hepatitis C virus-induced hepatocellular carcinoma

Goossens N, Hoshida Y

Hepatitis C virus (HCV) is a leading etiology of hepatocellular carcinoma (HCC). The interaction of HCV with its human host is complex and multilayered; stemming in part from the fact...
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Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases

Bansal R, Nakagawa S, Yazdani S, van Baarlen J, Venkatesh , Koh AP, Song WM, Goossens N, Watanabe H, Beasley MB, Powell CA, Storm G, Kaminski N, van Goor H, Friedman S, Hoshida Y, Prakash J

Tissue fibrosis, characterized by excessive accumulation of aberrant extracellular matrix (ECM) produced by myofibroblasts, is a growing cause of mortality worldwide. Understanding the factors that induce myofibroblastic differentiation is paramount...
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