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Advanced Paternal Age and Sperm DNA Fragmentation: A Systematic Review

Gonzalez DC, Ory J, Blachman-Braun R, Nackeeran S, Best JC, Ramasamy R

Purpose: Male ageing is often associated with defective sperm DNA remodeling mechanisms that result in poorly packaged chromatin and a decreased ability to repair DNA strand breaks. However, the impact...
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Comparison of Intratesticular Testosterone between Men Receiving Nasal, Intramuscular, and Subcutaneous Pellet Testosterone Therapy: Evaluation of Data from Two Single-Center Randomized Clinical Trials

Diaz P, Reddy R, Blachman-Braun R, Zucker I, Dullea A, Gonzalez DC, Kresch E, Ramasamy R

Purpose Testosterone replacement therapy (TRT) can potentially cause decreased spermatogenesis and subsequent infertility. Recent studies have suggested that 17-hydroxyprogesterone (17-OHP) is a reliable surrogate for intratesticular testosterone (ITT) that is essential...
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Artificial Intelligence Based Machine Learning Models Predict Sperm Parameter Upgrading after Varicocele Repair: A Multi-Institutional Analysis

Ory J, Tradewell MB, Blankstein U, Lima TF, Nackeeran S, Gonzalez DC, Nwefo E, Moryousef J, Madhusoodanan V, Lau S, Jarvi K, Ramasamy R

Purpose: Varicocele repair is recommended in the presence of a clinical varicocele together with at least one abnormal semen parameter, and male infertility. Unfortunately, up to 50% of men who...
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