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The Korean National Burden of Disease Study: from Evidence to Policy

Yoon SJ, Go DS, Park H, Jo MW, Oh IH, Kim YE

Following the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), disability-adjusted life years (DALYs) have been widely used as a summary measure of population health. The DALY metric...
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Effects of Aging and Smoking Duration on Cigarette Smoke-Induced COPD Severity

Kim EJ, Yoon SJ, Kim YE, Go DS, Jung Y

BACKGROUND: Aging can serve as an underlying mechanism of chronic obstructive pulmonary disease (COPD). Also, smoking, which is the most common cause of COPD, is responsible for the systemic manifestations...
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Inhibition of cell growth and induction of apoptosis by bilobalide in FaDu human pharyngeal squamous cell carcinoma

Jeong KI, Kim SG, Go DS, Kim DK

Bilobalide isolated from the leaves of Ginkgo biloba has several pharmacological activities such as neuroprotective, anti-inflammatory, and anticonvulsant. However, the effect of bilobalide on cancer has not been clearly established....
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Influence of Tyrosol on Cell Growth Inhibition of KB Human Oral Cancer Cells

Lee UK, Kim SG, Go DS, Yu SK, Kim CS, Kim J, Kim DK

Tyrosol, a phenylethanoid and a derivative of phenethyl alcohol, possesses various biological properties, such as anti-oxidative and cardioprotective activity. Olive oil is the principal source of tyrosol in the human...
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Effect of β-carotene on Cell Growth Inhibition of KB Human Oral Cancer Cells

Yang SS, Kim SG, Park BS, Go DS, Yu SK, Kim CS, Kim J, Kim DK

β-carotene is present in carrots, pumpkins, and sweet potatoes. It suppresses many types of cancers by regulating cellular proliferation and apoptosis through a variety of mechanisms. However, the effects of...
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Effect of Metformin on Cell Growth and Differentiation in Cultured Odontoblasts

Oh CY, Kim SG, Go DS, Yu SK, Kim TH, Kim CS, Park JC, Kim DK

Metformin (1,1-dimethylbiguanide hydrochloride), derived from French lilac (Galega officinalis), is a first-line anti-diabetic drug prescribed for patients with type 2 diabetes. However, the role of metformin in odontoblastic cell differentiation...
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Regional Differences in Years of Life Lost in Korea from 1997 to 2015

Go DS, Kim YE, Radnaabaatar M, Jung Y, Jung J, Yoon SJ

BACKGROUND: Reducing the gaps in health inequality at a regional level and improving health equity have been emphasized in Korea, it is essential to accurately measure the burden of disease...
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Health-Adjusted Life Expectancy (HALE) in Korea: 2005–2011

Lee JY, Ock M, Kim SH, Go DS, Kim HJ, Jo MW

Health-Adjusted Life Expectancy (HALE) is a summary measurement that estimates the average number of years that a person at a given age can expect to live an equivalent of full...
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Disability-Adjusted Life Years for Maternal, Neonatal, and Nutritional Disorders in Korea

Kim SH, Lee HJ, Ock M, Go DS, Kim HJ, Lee JY, Jo MW

Maternal and child health is an important issue throughout the world. Given their impact on maternal and child health, nutritional issues need to be carefully addressed. Accordingly, the effect of...
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MicroRNA-27 Promotes Odontoblast Differentiation via Wnt1 Signaling

Cho JH, Kim SG, Park BS, Go DS, Park JC, Kim DK

MicroRNA (miRNA, miR) is essential in regulating cell differentiation either by inhibiting mRNA translation or by inducing its degradation. However, the role of miRNA in odontoblastic cell differentiation is still...
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Effect of Resveratrol on Cell Differentiation and Mineralization in Cultured Odontoblasts

Shin SH, Kim JS, Kim SG, Go DS, Yu SK, Kim CS, Park JC, Kim DK

Resveratrol (3,4′,5,-trihydroxystilbene), a phytoalexin present in grapes, exerts a variety of actions to reduce superoxides, prevents diabetes mellitus, and inhibits inflammation. Resveratrol acts as a chemo-preventive agent and induces apoptotic...
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Trends and Patterns of Burden of Disease and Injuries in Korea Using Disability-Adjusted Life Years

Kim YE, Park H, Jo MW, Oh IH, Go DS, Jung J, Yoon SJ

BACKGROUND: It is extremely important to objectively take a view of population health to provide useful information to decision makers, health-sector leaders, researchers, and informed citizens. This study aims to...
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Measuring the Burden of Disease in Korea, 2008-2018

Jung YS, Kim YE, Park H, Oh IH, Jo MW, Ock M, Go DS, Yoon SJ

The study aims to examine the current status and differences in the burden of disease in Korea during 2008-2018. We calculated the burden of disease for Koreans from 2008 to...
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Apoptotic Activity of Curcumin and EF-24 in HTB-41 Human Salivary Gland Epidermoid Carcinoma Cells

Kim JW, Lee SA, Go DS, Park BS, Kim SG, Yu SK, Oh JS, Kim CS, Kim J, Park JT, Kim DK

Curcumin (diferuloylmethane), a constituent of turmeric powder derived from the rhizome of Curcuma longa, has been shown to inhibit the growth of various types of cancer cells by regulating cell...
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The Burden of Disease due to COVID-19 in Korea Using Disability-Adjusted Life Years

Jo MW, Go DS, Kim R, Lee SW, Ock M, Kim YE, Oh IH, Yoon SJ, Park H

Background: The world is currently experiencing a pandemic of coronavirus disease 2019 (COVID-19). In Korea, as in other countries, the number of confirmed cases and deaths due to COVID-19 have...
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Years of Life Lost Attributable to COVID-19 in High-incidence Countries

Oh IH, Ock M, Jang SY, Go DS, Kim YE, Jung YS, Kim KB, Park H, Jo MW, Yoon SJ

Background: The coronavirus disease 2019 (COVID-19) pandemic is a major public health problem of international concern. It is important to estimate its impact of COVID-19 for health policy decision-making. We...
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