- Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways
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Kim SJ, Jeong CW, Bae HB, Kwak SH, Son JK, Seo CS, Lee HJ, Lee J, Yoo KY
- KMID: 1372805
- J Korean Med Sci.
- 2012 May;27(5):572-575.
- doi: 10.3346/jkms.2012.27.5.572
Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of... -
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- The Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein, a toll-like receptor 4 agonist, enhances dendritic cell-based cancer vaccine potency
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Noh KT, Shin SJ, Son KH, Jung ID, Kang HK, Lee SJ, Lee EK, Shin YK, You JC, Park YM
- KMID: 1383795
- Exp Mol Med.
- 2012 May;44(5):340-349.
In this study, we showed the direct interaction between Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein (FAP) and toll-like receptor4 (TLR4) via co-localization and binding by using confocal microscopy and... -
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- 2-Deoxy-D-glucose regulates dedifferentiation through beta-catenin pathway in rabbit articular chondrocytes
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Yu SM, Kim HA, Kim SJ
- KMID: 1104210
- Exp Mol Med.
- 2010 Jul;42(7):503-513.
- doi: 10.3858/emm.2010.42.7.051
2-deoxy-D-glucose (2DG) is known as a synthetic inhibitor of glucose. 2DG regulates various cellular responses including proliferation, apoptosis and differentiation by regulation of glucose metabolism in cancer cells. However, the... -
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- Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt/GSK-3beta signaling pathway
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Jun HO, Kim DH, Lee SW, Lee HS, Seo JH, Kim JH, Kim JH, Yu YS, Min BH, Kim KW
- KMID: 991623
- Exp Mol Med.
- 2011 Jan;43(1):53-61.
- doi: 10.3858/emm.2011.43.1.006
Clusterin is a secretory glycoprotein, which is highly up-regulated in a variety of normal and injury tissues undergoing apoptosis including infarct region of the myocardium. Here, we report that clusterin... -
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- Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of beta-catenin, leading to a rapid proliferation of pancreatic cells
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Cho IR, Koh SS, Min HJ, Kim SJ, Lee Y, Park EH, Ratakorn S, Jhun BH, Oh S, Johnston R, Chung YH
- KMID: 1097265
- Exp Mol Med.
- 2011 Feb;43(2):82-90.
- doi: 10.3858/emm.2011.43.2.010
It is not yet understood how the enhanced expression of pancreatic adenocarcinoma up-regulated factor (PAUF; a novel oncogene identified in our recent studies), contributes to the oncogenesis of pancreatic cells.... -
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