- Amyloid-beta oligomers regulate the properties of human neural stem cells through GSK-3beta signaling
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Lee IS, Jung K, Kim IS, Park KI
- KMID: 2154279
- Exp Mol Med.
- 2013 Nov;45(11):e60.
Alzheimer's disease (AD) is the most common cause of age-related dementia. The neuropathological hallmarks of AD include extracellular deposition of amyloid-beta peptides and neurofibrillary tangles that lead to intracellular hyperphosphorylated... -
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- Haloperidol and clozapine differentially regulate signals pstream of glycogen synthase kinase 3 in the rat frontal cortex
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Roh MS, Seo MS, Kim Y, Kim SH, Jeon WJ, Ahn YM, Kang UG, Juhnn YS, Kim YS
- KMID: 1047086
- Exp Mol Med.
- 2007 Jun;39(3):353-360.
Glycogen synthase kinase 3 (GSK3) was recently suggested to be a potential target of psychotropics used in psychiatric illnesses such as schizophrenia and bipolar disorder. Relevant studies have found that... -
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- Activation of Akt/protein kinase B mediates the protective effects of mechanical stretching against myocardial ischemia-reperfusion injury
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Kim CH, Hao J, Ahn HY, Kim SW
- KMID: 1389762
- J Vet Sci.
- 2012 Sep;13(3):235-244.
- doi: 10.4142/jvs.2012.13.3.235
Akt/protein kinase B is a well-known cell survival factor and activated by many stimuli including mechanical stretching. Therefore, we evaluated the cardioprotective effect of a brief mechanical stretching of rat... -
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- Exendin-4 Protects Oxidative Stress-Induced beta-Cell Apoptosis through Reduced JNK and GSK3beta Activity
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Kim JY, Lim DM, Moon CI, Jo KJ, Lee SK, Baik HW, Lee KH, Lee KW, Park KY, Kim BJ
- KMID: 1779233
- J Korean Med Sci.
- 2010 Nov;25(11):1626-1632.
- doi: 10.3346/jkms.2010.25.11.1626
Oxidative stress induced by chronic hyperglycemia in type 2 diabetes plays a crucial role in progressive loss of beta-cell mass through beta-cell apoptosis. Glucagon like peptide-1 (GLP-1) has effects on... -
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