- Methods for the Assessment of Insulin Resistance
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Lee H
- KMID: 1703375
- J Korean Diabetes.
- 2014 Mar;15(1):7-11.
- doi: 10.4093/jkd.2014.15.1.7
Insulin resistance is one of the major aggravating factors for metabolic disease. There are many methods available for estimation of insulin resistance which range from complex techniques down to simple... -
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- Measurement of Insulin Sensitivity Index Estimated from LDIGIT ( Continuous Low Dose Insulin and Glucose Infusion Test
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Song YD, Cha BS, Park SW, Won YJ, Nam SY, Lim SK, Kim KR, Lee HC, Huh KB
- KMID: 2008326
- J Korean Diabetes Assoc.
- 1997 Dec;21(4):425-431.
BACKGROUND: Measurement of insulin sensitivity index by continuous low dose insulin and glucose infusion test(LDIGIT) has been reported to be simple and reliable. METHODS: The method is a refinement of... -
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- Short Insulin Tolerance Test(SITT) for the Determination of in vivo Insulin Sensitivity-A Comparison with Euglycemic Clamp Test
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Park SW, Yun YS, Ahn CW, Nam JH, Kwon SH, Song MK, Han SH, Cha BS, Son YD, Lee HC, Huh KB
- KMID: 2178014
- J Korean Diabetes Assoc.
- 1998 Jun;22(2):199-208.
BACKGROUND: The euglycemic hyperinsulinemic clamp technique is currently regarded as gold standard for measuring insulin sensitivity, but it requires sophisticated equipment and highly trained personnel. We investigated the reliability of... -
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- Effect of Persistent Mild Hyperglycemic Hyperinsulinemia on Development of Insulin Resistance in Rats
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Kim YW, Park JH, Park SY, Kim JY, Lee SK
- KMID: 2320377
- Yeungnam Univ J Med.
- 1995 Dec;12(2):269-281.
- doi: 10.12701/yujm.1995.12.2.269
The effect of persistant mild hyperglycemic hyperinsulinemia on the development of the insulin resistance in rats was studied in vivo. Also, the characteristics of the insulin resistance compared with the... -
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- Usefulness of Oral Glucose Insulin Sensitivity Index in Women with Polycystic Ovary Syndrome
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Oh JY, Lee H, Sung YA
- KMID: 2283966
- Ewha Med J.
- 2011 Sep;34(2):27-32.
- doi: 10.12771/emj.2011.34.2.27
OBJECTIVES: Insulin resistance is a major pathophysiology in polycystic ovary syndrome (PCOS), and assessment of insulin sensitivity is important. Various insulin sensitivity indices from fasting state or oral glucose tolerance... -
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- The Effect of Elevated Plasma Free Fatty Acids on Non-Insulin-Mediated Glucose Uptake and Insulin Resistance
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Min YK, Ahn JH, Koh JJ, Lee HK, Min HK
- KMID: 2331647
- J Korean Diabetes Assoc.
- 1998 Mar;22(1):47-55.
BACKGROUND: In vivo glucose uptake occurs via two mechanisms, namely insulin-mediated glucose uptake(IMGU) and non-insulin-mediated glucose up-take(NIMGU). NIMGU accaunts for about 70~85% of postabsorptive glucose uptake. Despite many studies, it... -
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- The Role of Insulin Secretion and Insulin Resistance in the Development of Korean Type 2 Diabetes Mellitus
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Chae BN, Lee SK, Hong EG, Chung YS, Lee KW, Kim HM
- KMID: 2331693
- J Korean Diabetes Assoc.
- 1998 Dec;22(4):491-503.
BACKGROUND: Impaired insulin secretinn, peripheral insulin resistance, a disproportionately elevated rate of hepatic glucose production and influence of inherited or enviromental factors contribute to the pathogenesis of type 2 diabetes... -
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- Thiazolidinediones on Insulin Resistance and Insulin Secretion in Obese Diabetic OLETF Rats
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Noh JH, Hong SH, Lee KH, Min KM, Yang TY, Lee MS, Kim KW, Lee MK
- KMID: 2008094
- J Korean Diabetes Assoc.
- 2007 Jan;31(1):33-43.
- doi: 10.4093/jkda.2007.31.1.33
BACKGROUND: Thiazolidinediones are synthetic peroxisome proliferator-activated receptor-gamma agonists that decrease insulin resistance but, as in vitro and in vivo studies suggest, may have direct beneficial effects on pancreatic beta cells.... -
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- Effects of Cilostazol on Insulin Resistance in OLETF Rats
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Kim SR, Baek KH, Ko SH, Lee JM, Chang SA, Ahn YB, Yoo SJ, Lee JM, Son HS, Yoon KH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK
- KMID: 2010070
- J Korean Diabetes Assoc.
- 2001 Feb;25(1):63-70.
BACKGROUND: Insulin resistance is one of the major pathophysiology of type 2 diabetes mellitus. It is reported that cilostazol and cyclic AMP phosphodiesterase inhibitor has the anti-platelet effect as well... -
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- Limitation of Validity of Homeostasis Model Assessment as a Index of Insulin Resistance
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Yun YS, Park SW, Song YD, Park HK, Kim OY, Ahn CW, Nam JH, Nam SY, Cha BS, Lee CH, Lim SG, Kim KR, Lee HC, Huh KB
- KMID: 2331730
- J Korean Diabetes Assoc.
- 2000 Oct;24(5):541-551.
BACKGROUND: Homeostasis model assessment of insulin resistance (HOMAIR) had been proposed as a simple and inexpensive alternative to other complex procedures measuring insulin resistance. We evaluated the validity of HOMAIR,... -
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- Effect of Exercise Training on Insulin Sensitivity and Intracellular Glucose Metabolism in Skeletal Muscle of High Fat-fed Rats
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Kim CH, Park JY, Hong SK, Park KS, Lee HK, Lee KU
- KMID: 2178017
- J Korean Diabetes Assoc.
- 1998 Jun;22(2):231-242.
BACKGROUND: Insulin resistance is a major characteristic of non-insulin-dependent diabetes mellitus and obesity. Many studies have indicated that increased intake of fat are associated with obesity and insulin resistance. On... -
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- Characteristics of Convective Transport of Glucose During Peritoneal Dialysis
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Lee EY, Yoon KI, Park MS, Suh KI, Lee HB
- KMID: 2254842
- Korean J Nephrol.
- 1997 Jun;16(2):281-289.
The sieving coefficient(S) representing convective transport of glucose during peritoneal dialysis(PD) with glucose containing dialysis solution has been reported to be anomalous, lower than 0 or higher than 1. During... -
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- Impaired Metabolic Signal Transduction Networks in Isolated Skeletal Muscle in Korean type 2 Diabetic Patients
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Choi JH, Lee KW, Kim HJ, Lee DH, Lee JW, Kim JE, Yim HC, Kim KM, Choi SY, Chung YS, Kim HM
- KMID: 2200049
- J Korean Soc Endocrinol.
- 2002 Oct;17(5):685-697.
BACKGROUND: The glucose uptake rate is the limiting step in glucose utilization and storage. The failure of insulin to stimulate glucose uptake in muscle appears to be a primary defect... -
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- Gly1057Asp Polymorphism of the Insulin Receptor Substrate-2 Genes May Not Have a Significant Impact on Insulin Resistance in Korean Women with Polycystic Ovary Syndrome
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Oh JY, Oh JY, Sung YA, Lee HJ, Chung HW
- KMID: 1468504
- J Korean Endocr Soc.
- 2009 Jun;24(2):100-108.
- doi: 10.3803/jkes.2009.24.2.100
BACKGROUND: Insulin resistance is a key factor in the pathogenesis of polycystic ovary syndrome (PCOS), and several candidate genes involved in insulin action such as insulin receptor or insulin recpetor... -
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- A High Carbohydrate Diet Induces Insulin Resistance Through Decreased Glucose Utilization in Ovariectomized Rats
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Park SM, Park CH, Wha JD, Choi SB
- KMID: 759693
- Korean J Intern Med.
- 2004 Jun;19(2):87-92.
BACKGROUND: Recent research has reported that high sugar diets increase insulin resistance, without abdominal obesity, in male, but not female Wister rats. Whether a high sucrose (SU) diet increased insulin... -
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- The Study of Alteration of Beta Cells in Pancreatic Islets, Glusoce Metabolism and Insulin Secretion in Low Dose Streptozotocin Indeced Type 2 Diabetic Rat Model
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Shin YG, Kim HS, Lee MD, Kim YU, Kang HS, Hwang TS, Chung CH
- KMID: 2063338
- J Korean Diabetes Assoc.
- 1999 Jun;23(3):256-268.
BACKGROUND: Korean diabetes is different from western diabetes due to the racial differences in genetic factors and susceptability. It has recently been suggested that thrifty phenotype hypothesis is related to... -
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- Surgical removal of visceral fat decreases plasma free fatty acid and increases insulin sensitivity on liver and peripheral tissue in monosodium glutamate (MSG)-obese rats
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Kim YW, Kim JY, Lee SK
- KMID: 646022
- J Korean Med Sci.
- 1999 Oct;14(5):539-545.
- doi: 10.3346/jkms.1999.14.5.539
In order to evaluate the role of visceral and subcutaneous fat tissue in insulin sensitivity and lipid metabolism, we measured the fasting levels of plasma free fatty acid (FFA) and... -
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- Effects of High Fat Diet on Lipolysis in Skeletal Muscle and Adipose Tissue in Rats
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Kim CH, Chung YE, Lee SJ, Park JY, Hong SK, Kim HK, Suh KI, Lee KU
- KMID: 1767980
- J Korean Diabetes Assoc.
- 2000 Dec;24(6):641-651.
BACKGROUND: It has been hypothesized that increased fat oxidation reduces glucose utilization in skeletal muscle, and is responsible for the insulin resistance associated with obesity or high-fat feeding. In contrast,... -
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- Nitric Oxide Increases Insulin Sensitivity in Skeletal Muscle by Improving Mitochondrial Function and Insulin Signaling
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Lee WJ, Kim HS, Park HS, Kim MO, Kim M, Yun JY, Kim EH, Lee SA, Lee SH, Koh EH, Park JY, Lee KU
- KMID: 2222419
- Korean Diabetes J.
- 2009 Jun;33(3):198-205.
- doi: 10.4093/kdj.2009.33.3.198
BACKGROUND: Accumulating evidence has suggested that nitric oxide (NO) is involved in the regulation of insulin sensitivity in skeletal muscle. Recent studies also suggested NO as an important molecule regulating... -
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- The Combined Effects of Protein Malnutrition and Chronic Alcohol lntake on lnsulin Secretion and Sensitivity in Growing Rats
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Cha BS, Ahn CW, Lee HI, Yoon YS, Sung JK, Song YD, Lim SK, Kim KR, Lee HC, Huh KB
- KMID: 1539927
- J Korean Diabetes Assoc.
- 2000 Feb;24(1):19-36.
BACKGROUND: This investigation was performed to examine the combined effects of protein malnutrition and chronic moderate amount of alcohol intake on insulin secretory capacity and sensitivity in growing rats. METHODS: Weanling... -
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