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Identification of urinary microRNA biomarkers for in vivo gentamicininduced nephrotoxicity models

Jeon BS, Lee Sh, Hwang SR, Yi H, Bang JH, Tham NTT, Lee HK, Woo GH, Kang HG, Ku HO

Background: Although previous in vivo studies explored urinary microRNA (miRNA), there is no agreement on nephrotoxicity-specific miRNA biomarkers. Objectives: In this study, we assessed whether urinary miRNAs could be employed as...
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Vancomycin and Aminoglycoside Antibiotic Drug Concentration Measurement: Current Status in Clinical Laboratories in Korea

Kwon WK, Oh J, Lee SY, Park HD

Background: Therapeutic drug monitoring (TDM) is clinically recommended for vancomycin and aminoglycoside antibiotics owing to their narrow therapeutic range and nephrotoxicity at high concentrations in the blood. This study was...
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Intratympanic Gentamicin Versus Labyrinthectomy: Inner Ear Sensitivity to Gentamicin and Impact on the Contralateral Labyrinth

Kontorinis G, Tailor H, Gaggini M, Crowther J

OBJECTIVES: To investigate the impact of labyrinthectomy and intratympanic (IT) gentamicin injections on the contralateral labyrinth, we also assessed the response of each individual semicircular canal to each IT gentamicin...
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A Case of Recurrent Vertigo in Vestibular Schwannoma Treated with Chemical Labyrinthectomy

Lee SJ, Lee ES, Kim BG, Lee JD

Vestibular schwannoma (VS) can have various symptoms and almost half of the patients have balance problems. Some patients with VS can suffer from recurrent vertigo mimicking Meniere's disease. We present...
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The Use of Gentamicin-Impregnated Collagen Sponge for Reducing Surgical Site Infection after Spine Surgery

Han JS, Kim SH, Jin SW, Lee SH, Kim BJ, Kim SD, Lim DJ

OBJECTIVE: Surgical site infection (SSI) is the one of the most frequent complications in hospitalized patients, and it extends hospital stays and causes extra morbidities. To reduce SSI after spine...
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A Simple, Reproducible, Inexpensive, Yet Old-Fashioned Method for Determining Phagocytic and Bactericidal Activities of Macrophages

Kaneko M, Emoto Y, Emoto M

Macrophages (Mphi) play a pivotal role in the protection system by recognizing and eliminating invading pathogenic bacteria. Phagocytosis and the killing of invading bacteria are major effector functions of Mphi....
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The Effect of Garlic Derivatives (S-Allylmercaptocysteine, Diallyl Disulfide, and S-Allylcysteine) on Gentamicin Induced Ototoxicity: An Experimental Study

Uzun L, Kokten N, Cam OH, Kalcioglu , Ugur MB, Tekin M, Acar GO

OBJECTIVES: Gentamicin is a potent aminoglycoside antibiotic. Ototoxicity and nephrotoxicity are the main side effects which restrict the use of gentamicin. Garlic with its intrinsic antioxidant activity may prove beneficial...
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The Inhibitory Mechanism of Gentamicin on Electrical Field Stimulation Response in Rat Bladder Smooth Muscle

Min CH, Wang Y, Bae J, Han JH, Sohn UD

To see the inhibitory mechanism of gentamicin in response to electrical field stimulation (EFS) using the rat bladder smooth muscle, atropine or guanethidine was treated but had no effect. Methylsergide,...
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The effect of high concentration of magnesium with ropivacaine, gentamicin, rocuronium, and their combination on neuromuscular blockade

Rhee WJ, Lee SY, Lee JH, Choi SR, Lee SC, Lee JH, Lee SI

BACKGROUND: Magnesium, ropivacaine, gentamicin, and rocuronium block neuromuscular (NM) transmission by different mechanisms. Therefore, concurrent administration of these agents may induce prolonged muscle paralysis via synergistic interaction. This study investigated...
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Gentamicin-Induced Macular Toxicity after Transconjunctival Sutureless 23-Gauge Vitrectomy with Prophylactic Subconjunctival Gentamicin Injection

Jin H, Kim MH, Song JH

  • KMID: 2338750
  • J Korean Ophthalmol Soc.
  • 2014 Jun;55(6):936-940.
PURPOSE: To report a case of macular toxicity due to gentamicin after transconjunctival 23-gauge sutureless vitrectomy with prophylactic subconjunctival gentamicin injection. CASE SUMMARY: A 60-year-old female presented to our department with...
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The Protective Effect of Epigallocatechin-3-Gallate Against Gentamicin Vestibular Ototoxicity in Type I Vestibular Hair Cell of Guinea Pig

Choi YH, Lee SS, Moon SJ, Ahn BH, Kim NG, Jeong HS, Park JS, Cho HH, Cho YB

BACKGROUND AND OBJECTIVES: Gentamicin (GM) is well known for its vestibulotoxicity. There have been many reports about vestibulotoxicity, however, its mechanism is still unclear. So far, it is known that...
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Protective Effect of Hexane and Ethanol Extract of Piper Longum L. on Gentamicin-Induced Hair Cell Loss in Neonatal Cultures

Yadav MK, Choi J, Song JJ

  • KMID: 2278396
  • Clin Exp Otorhinolaryngol.
  • 2014 Mar;7(1):13-18.
OBJECTIVES: Gentamicin (GM) is a commonly used aminoglycoside antibiotic that generates free oxygen radicals within the inner ear, which can cause vestibulo-cochlear toxicity and permanent damage to the sensory hair...
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Protective Effect of Metformin on Gentamicin-Induced Vestibulotoxicity in Rat Primary Cell Culture

Lee JY, Lee SH, Chang JW, Song JJ, Jung HH, Im GJ

OBJECTIVES: One of the antidiabetic drugs, metformin, have shown that it prevented oxidative stress-induced death in several cell types through a mechanism involving the opening of the permeability transition pore...
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Ischemic Retinopathy Due to Suspicious Gentamicin Retinal Toxicity after Primary Repair of Scleral Laceration

Kim JM, Ghim WH, Cho WH, Kyung SE, Chang MH

PURPOSE: To report a case of ischemic retinopathy due to suspicious gentamicin retinal toxicity after primary repair of a scleral laceration. CASE SUMMARY: A 45-year-old man presented to our department with...
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Do bupivacaine, clindamycin, and gentamicin at their clinical concentrations enhance rocuronium-induced neuromuscular block?

Lee SI, Lee JH, Park SY, Park JW

BACKGROUND: Bupivacaine, clindamycin, and gentamicin inhibit neuromuscular (NM) conduction. When they are combined, they may synergistically reduce the effective concentration of each to the therapeutic concentration in augmenting rocuronium-induced NM...
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Protective Effects of Houttuynia cordata Thunb. on Gentamicin-induced Oxidative Stress and Nephrotoxicity in Rats

Kang C, Lee H, Hah DY, Heo JH, Kim CH, Kim E, Kim JS

  • KMID: 2317817
  • Toxicol Res.
  • 2013 Mar;29(1):61-67.
Development of a therapy providing protection from, or reversing gentamicin-sulfate (GS)-induced oxidative stress and nephrotoxicity would be of great clinical significance. The present study was designed to investigate the protective...
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Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerability

Lee JH, Park C, Kim SJ, Kim HJ, Oh GS, Shen A, So HS, Park R

  • KMID: 2154231
  • Exp Mol Med.
  • 2013 Mar;45(3):e12.
Hair cells at the base of the cochlea appear to be more susceptible to damage by the aminoglycoside gentamicin than those at the apex. However, the mechanism of base-to-apex gradient...
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The synergistic effect of gentamicin and clindamycin on rocuronium-induced neuromuscular blockade

Lee JH, Lee SI, Chung CJ, Lee JH, Lee SC, Choi SR, Oh JN, Bae JY

BACKGROUND: Gentamicin reduces acetylcholine release and clindamycin causes end-plate ion channel blockade. Because of these reasons, two drugs show muscular relaxant effect and potentiate the action of nondepolarizing neuromuscular agents....
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Antiapoptotic Effect of Paricalcitol in Gentamicin-induced Kidney Injury

Suh SH, Lee KE, Park JW, Kim IJ, Kim O, Kim CS, Choi JS, Bae EH, Ma SK, Lee JU, Kim SW

While the anti-apoptotic effect of paricalcitol has been demonstrated in various animal models, it is not yet clear whether paricalcitol attenuates the apoptosis in gentamicin (GM)-induced kidney injury. We investigated...
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A Case of Posterior Fossa Meningioma Presenting with Meniere's-Like Symptoms

Park JH, Song JJ, Kim JS, Koo JW

Posterior fossa meningioma located on the endolymphatic sac may present Meniere's disease-like symptoms possibly due to endolymphatic hydrops by tumor compression. A 70-year-old woman presented with recurrent vertigo and combined...
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