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Editor’s introduction to this issue (G&I 20:2, 2022)

Park T

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Mathematical modeling of the impact of Omicron variant on the COVID-19 situation in South Korea

Oh J, Apio C, Park T

The rise of newer coronavirus disease 2019 (COVID-19) variants has brought a challenge to ending the spread of COVID-19. The variants have a different fatality, morbidity, and transmission rates and...
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Identification of the associations between genes and quantitative traits using entropy-based kernel density estimation

Yee J, Park T, Park M

Genetic associations have been quantified using a number of statistical measures. Entropy-based mutual information may be one of the more direct ways of estimating the association, in the sense that...
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Bayesian analysis of longitudinal traits in the Korea Association Resource (KARE) cohort

Chung W, Hwang H, Park T

Various methodologies for the genetic analysis of longitudinal data have been proposed and applied to data from large-scale genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with...
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Integrated bioinformatics analysis of validated and circulating miRNAs in ovarian cancer

Dogan B, Gumusoglu E, Ulgen E, Sezerman OU, Gunel T

Recent studies have focused on the early detection of ovarian cancer (OC) using tumor materials by liquid biopsy. The mechanisms of microRNAs (miRNAs) to impact OC and signaling pathways are...
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A novel mutation in GJC2 associated with hypomyelinating leukodystrophy type 2 disorder

Komachali SR, Sheikholeslami M, Salehi M

Hypomyelinating leukodystrophy type 2 (HLD2), is an inherited genetic disease of the central nervous system caused by recessive mutations in the gap junction protein gamma 2 (GJC2/GJA12). HLD2 is characterized...
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Comparison of survival prediction models for pancreatic cancer: Cox model versus machine learning models

Kim H, Park T, Jang J, Lee S

A survival prediction model has recently been developed to evaluate the prognosis of resected nonmetastatic pancreatic ductal adenocarcinoma based on a Cox model using two nationwide databases: Surveillance, Epidemiology and...
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In silico genome wide identification and expression analysis of the WUSCHEL-related homeobox gene family in Medicago sativa

Yang T, Gao T, Wang C, Wang X, Chen C, Tian M, Yang W

Alfalfa (Medicago sativa) is an important food and feed crop which rich in mineral sources. The WUSCHEL-related homeobox (WOX) gene family plays important roles in plant development and identification of...
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Genome characterization and mutation analysis of human influenza A virus in Thailand

Rattanaburi S, Sawaswong V, Nimsamer P, Mayuramart O, Sivapornnukul P, Khamwut A, Chanchaem P, Kongnomnan K, Suntronwong N, Poovorawan Y, Payungporn S

The influenza A viruses have high mutation rates and cause a serious health problem worldwide. Therefore, this study focused on genome characterization of the viruses isolated from Thai patients based...
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Associations between single-nucleotide polymorphisms of the interleukin-18 gene and breast cancer in Iraqi women

Zakariya BF, Almohaidi AMS, Şimşek SA, Kamal AM, Al-Dabbagh WH, Al-Waysi SA

According to long-term projections, by 2030, the world’s population is predicted to reach 7.5 billion individuals, and there will be roughly 27 million new cancer cases diagnosed. The global burden...
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