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Web-Based Database and Viewer of East Asian Copy Number Variations

Kim JH, Hu HJ, Chung YJ

We have discovered copy number variations (CNVs) in 3,578 Korean individuals with the Affymetrix Genome-Wide SNP array 5.0, and 4,003 copy number variation regions (CNVRs) were defined in a previous...
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Comparative Evaluation of Intron Prediction Methods and Detection of Plant Genome Annotation Using Intron Length Distributions

Yang L, Cho HG

Intron prediction is an important problem of the constantly updated genome annotation. Using two model plant (rice and Arabidopsis) genomes, we compared two well-known intron prediction tools: the Blast-Like Alignment...
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An Efficient Approach to Mining Maximal Contiguous Frequent Patterns from Large DNA Sequence Databases

Karim MR, Rashid MM, Jeong BS, Choi HJ

Mining interesting patterns from DNA sequences is one of the most challenging tasks in bioinformatics and computational biology. Maximal contiguous frequent patterns are preferable for expressing the function and structure...
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Efficient Mining of Interesting Patterns in Large Biological Sequences

Rashid MM, Karim MR, Jeong BS, Choi HJ

Pattern discovery in biological sequences (e.g., DNA sequences) is one of the most challenging tasks in computational biology and bioinformatics. So far, in most approaches, the number of occurrences is...
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Decreases in Casz1 mRNA by an siRNA Complex Do not Alter Blood Pressure in Mice

Ji SM, Shin YB, Park SY, Lee HJ, Oh B

Recent genomewide association studies of large samples have identified genes that are associated with blood pressure. The Global Blood Pressure Genetics (Global BPgen) and Cohorts for Heart and Aging Research...
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CaGe: A Web-Based Cancer Gene Annotation System for Cancer Genomics

Park YK, Kang TW, Baek SJ, Kim KI, Kim SY, Lee D, Kim YS

High-throughput genomic technologies (HGTs), including next-generation DNA sequencing (NGS), microarray, and serial analysis of gene expression (SAGE), have become effective experimental tools for cancer genomics to identify cancer-associated somatic genomic...
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Possibility of the Use of Public Microarray Database for Identifying Significant Genes Associated with Oral Squamous Cell Carcinoma

Kim KY, Cha IH

There are lots of studies attempting to identify the expression changes in oral squamous cell carcinoma. Most studies include insufficient samples to apply statistical methods for detecting significant gene sets....
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Differential Expression of PKD2-Associated Genes in Autosomal Dominant Polycystic Kidney Disease

Yook YJ, Woo YM, Yang MH, Ko JY, Kim BH, Lee EJ, Chang ES, Lee MJ, Lee S, Park JH

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of multiple fluid-filled cysts that expand over time and destroy renal architecture. The proteins encoded by the PKD1 and PKD2...
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CysQ of Cryptosporidium parvum, a Protozoa, May Have Been Acquired from Bacteria by Horizontal Gene Transfer

Lee JY, Kim S

Horizontal gene transfer (HGT) is the movement of genetic material between kingdoms and is considered to play a positive role in adaptation. Cryptosporidium parvum is a parasitic protozoan that causes...
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Survey of the Applications of NGS to Whole-Genome Sequencing and Expression Profiling

Lim JS, Choi BS, Lee JS, Shin C, Yang TJ, Rhee JS, Lee JS, Choi IY

Recently, the technologies of DNA sequence variation and gene expression profiling have been used widely as approaches in the expertise of genome biology and genetics. The application to genome study...
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