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Preliminary Study of Bioinformatics Patents and Their Classifications Registered in the KIPRIS Database

Park HS

Whereas a vast amount of new information on bioinformatics is made available to the public through patents, only a small set of patents are cited in academic papers. A detailed...
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Developing JSequitur to Study the Hierarchical Structure of Biological Sequences in a Grammatical Inference Framework of String Compression Algorithms

Galbadrakh B, Lee KE, Park HS

Grammatical inference methods are expected to find grammatical structures hidden in biological sequences. One hopes that studies of grammar serve as an appropriate tool for theory formation. Thus, we have...
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QCanvas: An Advanced Tool for Data Clustering and Visualization of Genomics Data

Kim N, Park H, He N, Lee HY, Yoon S

We developed a user-friendly, interactive program to simultaneously cluster and visualize omics data, such as DNA and protein array profiles. This program provides diverse algorithms for the hierarchical clustering of...
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Network Graph Analysis of Gene-Gene Interactions in Genome-Wide Association Study Data

Lee S, Kwon MS, Park T

Most common complex traits, such as obesity, hypertension, diabetes, and cancers, are known to be associated with multiple genes, environmental factors, and their epistasis. Recently, the development of advanced genotyping...
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A Fosmid Cloning Strategy for Detecting the Widest Possible Spectrum of Microbes from the International Space Station Drinking Water System

Choi S, Chang MS, Stuecker T, Chung C, Newcombe D, Venkateswaran K

In this study, fosmid cloning strategies were used to assess the microbial populations in water from the International Space Station (ISS) drinking water system (henceforth referred to as Prebiocide and...
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Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature Mining

Lim JE, Hong KW, Jin HS, Oh B

Oxidative stress, which results in an excessive product of reactive oxygen species (ROS), is one of the fundamental mechanisms of the development of hypertension. In the vascular system, ROS have...
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Finding Genetic Risk Factors of Gestational Diabetes

Kwak SH, Jang HC, Park KS

Gestational diabetes mellitus (GDM) is a complex metabolic disorder of pregnancy that is suspected to have a strong genetic predisposition. It is associated with poor perinatal outcome, and both GDM...
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Understanding Disease Susceptibility through Population Genomics

Han S, Lee J, Kim S

Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. A number of proximal and remote DNA variations, known as expression...
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Transposable Elements: No More 'Junk DNA'

Kim YJ, Lee J, Han K

Since the advent of whole-genome sequencing, transposable elements (TEs), just thought to be 'junk' DNA, have been noticed because of their numerous copies in various eukaryotic genomes. Many studies about...
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A Short History of the Genome-Wide Association Study: Where We Were and Where We Are Going

Ikegawa S

Recent rapid advances in genetic research are ushering us into the genome sequence era, where an individual's genome information is utilized for clinical practice. The most spectacular results of the...
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Application of Whole Exome Sequencing to Identify Disease-Causing Variants in Inherited Human Diseases

Goh G, Choi M

The recent advent of next-generation sequencing technologies has dramatically changed the nature of biomedical research. Human genetics is no exception-it has never been easier to interrogate human patient genomes at...
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Editor's Introduction to This Issue

Kim S

No abstract available.
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