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A Scheme for Filtering SNPs Imputed in 8,842 Korean Individuals Based on the International HapMap Project Data

Lee K, Kim S

  • KMID: 2053233
  • Genomics Inform.
  • 2009 Jun;7(2):136-140.
Genome-wide association (GWA) studies may benefit from the inclusion of imputed SNPs into their dataset. Due to its predictive nature, the imputation process is typically not perfect. Thus, it would...
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Comparison of Exon-boundary Old and Young Domains during Metazoan Evolution

Lee B

  • KMID: 2053232
  • Genomics Inform.
  • 2009 Jun;7(2):131-135.
Domains are the building blocks of proteins. Exon shuffling is an important mechanism accounting for combination of a limited repertoire of protein domains in the evolution of multicellular species. A...
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Integrative Analysis of Microarray Data with Gene Ontology to Select Perturbed Molecular Functions using Gene Ontology Functional Code

Kim C, Choi J, Yoon S

  • KMID: 2053231
  • Genomics Inform.
  • 2009 Jun;7(2):122-130.
A systems biology approach for the identification of perturbed molecular functions is required to understand the complex progressive disease such as breast cancer. In this study, we analyze the microarray...
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Evolutionary Signature of Information Transfer Complexity in Cellular Membrane Proteomes

Kim JM, Kim BG, Oh SJ

  • KMID: 2053230
  • Genomics Inform.
  • 2009 Jun;7(2):111-121.
Cell membrane proteins play crucial roles in the cell's molecular interaction with its environment and within itself. They consist of membrane-bound proteins and many types of transmembrane (TM) proteins such...
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Investigation of Genetic Evidence for Sasang Constitution Types in South Korea

Lee MK, Jang ES, Sohn HY, Park JY, Koh BH, Sung J, Kim JI, Kim JY, Seo JS

  • KMID: 2053229
  • Genomics Inform.
  • 2009 Jun;7(2):107-110.
In Sasang constitutional medicine, both disease susceptibility and drug response are considered to be related to the characteristics of an individual's physiology and psychology: a theory which is central...
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High-concentration Epigallocatechin Gallate Treatment Causes Endoplasmic Reticulum Stress-mediated Cell Death in HepG2 Cells

Ahn JI, Jeong KJ, Ko MJ, Shin HJ, Chung HJ, Jeong HS

  • KMID: 2053228
  • Genomics Inform.
  • 2009 Jun;7(2):97-106.
Epigallocatechin gallate (EGCG), a well-known antioxidant molecule, has been reported to cause hepatotoxicity when used in excess. However, the mechanism underlying EGCG-induced hepatotoxicity is still unclear. To better understand the...
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Analysis of Gene Expression in Mouse Spinal Cord-derived Neural Precursor Cells During Neuronal Differentiation

Ahn JI, Kim SY, Ko MJ, Chung HJ, Jeong HS

  • KMID: 2053227
  • Genomics Inform.
  • 2009 Jun;7(2):85-96.
The differentiation of neural precursor cells (NPCs) into neurons and astrocytes is a process that is tightly controlled by complicated and ill-defined gene networks. To extend our knowledge to gene...
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Identification of 1,531 cSNPs from Full-length Enriched cDNA Libraries of the Korean Native Pig Using in Silico Analysis

Oh Y, Nguyen DT, Park K, Dirisala V, Choi H, Park C

  • KMID: 2053226
  • Genomics Inform.
  • 2009 Jun;7(2):65-84.
Sequences from the clones of full-length enriched cDNA libraries serve as valuable resources for functional genomics related studies, genome annotation and SNP discovery. We analyzed 7,392 high-quality chromatograms (Phred value...
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Association between Single Nucleotide Polymorphisms of the Fibrinogen Alpha Chain (FGA) Gene and Type 2 Diabetes Mellitus in the Korean Population

Hwang JY, Ryu MH, Go MJ, Oh B, Cho YS

  • KMID: 2053225
  • Genomics Inform.
  • 2009 Jun;7(2):57-64.
Fibrinogen alpha chain (FGA), a subunit of fibrinogen, might be a potential player for type 2 diabetes mellitus (T2DM), since the plasma levels of fibrinogen is known to be related...
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Identification of Genetic Variations in CBL, SORBS1, CRK, and RHOQ,Key Modulators in the CAP/TC10 Pathway of Insulin Signal Transduction and Their Association with Type 2 Diabetes Mellitus in the Korean Population

Hong KW, Jin HS, Lim JE, Go MJ, Lee JY, Hwang SY, Park HK, Oh B

  • KMID: 2053224
  • Genomics Inform.
  • 2009 Jun;7(2):53-56.
Recent evidence has strongly suggested that the CAP/TC10 pathway is involved in the trafficking, docking,and fusion of vesicles containing the insulin- responsive glucose transporter Glut4 to the plasma membrane. However,...
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