- Personal Genomics, Bioinformatics, and Variomics
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Bhak J, Ghang H, Reja R, Kim S
- KMID: 2166415
- Genomics Inform.
- 2008 Dec;6(4):161-165.
In 2008 at least five complete genome sequences are available. It is known that there are over 15,000,000 genetic variants, called SNPs, in the dbSNP database. The cost of full... -
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- Biological Pathway Extension Using Microarray Gene Expression Data
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Chung TS, Kim J, Kim K, Kim JH
- KMID: 2166420
- Genomics Inform.
- 2008 Dec;6(4):202-209.
Biological pathways are known as collections of knowledge of certain biological processes. Although knowledge about a pathway is quite significant to further analysis, it covers only tiny portion of genes... -
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- Computational Approach for the Analysis of Post-PKS Glycosylation Step
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Kim KB, Park K
- KMID: 2166422
- Genomics Inform.
- 2008 Dec;6(4):223-226.
We introduce a computational approach for analysis of glycosylation in Post-PKS tailoring steps. It is a computational method to predict the deoxysugar biosynthesis unit pathway and the substrate specificity of... -
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- Computational Approach for Biosynthetic Engineering of Post-PKS Tailoring Enzymes
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Kim KB, Park K
- KMID: 2166423
- Genomics Inform.
- 2008 Dec;6(4):227-230.
Compounds of polyketide origin possess a wealth of pharmacological effects, including antibacterial, antifungal, antiparasitic, anticancer and immunosuppressive activities. Many of these compounds and their semisynthetic derivatives are used today in... -
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- In Silico Functional Assessment of Sequence Variations: Predicting Phenotypic Functions of Novel Variations
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Won HH, Kim JW
- KMID: 2166416
- Genomics Inform.
- 2008 Dec;6(4):166-172.
A multitude of protein-coding sequence variations (CVs) in the human genome have been revealed as a result of major initiatives, including the Human Variome Project, the 1000 Genomes Project, and... -
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- Microarray Data Analysis of Perturbed Pathways in Breast Cancer Tissues
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Kim C, Choi J, Yoon S
- KMID: 2166421
- Genomics Inform.
- 2008 Dec;6(4):210-222.
Due to the polygenic nature of cancer, it is believed that breast cancer is caused by the perturbation of multiple genes and their complex interactions, which contribute to the wide... -
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- Identification and Characterization of Human Genes Targeted by Natural Selection
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Ryu HJ, Kim YJ, Park YK, Kim JJ, Park MY, Seo EJ, Yoo HW, Park IS, Oh B, Lee JK
- KMID: 2166417
- Genomics Inform.
- 2008 Dec;6(4):173-180.
The human genome has evolved as a consequence of evolutionary forces, such as natural selection. In this study, we investigated natural selection on the human genes by comparing the numbers... -
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- Erythropoietin-producing Human Hepatocellular Carcinoma Receptor B1 Polymorphisms are Associated with HBV-infected Chronic Liver Disease and Hepatocellular Carcinoma in a Korean Population
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Kim KY, Lee SK, Kim MH, Cheong JY, Cho SW, Yang KS, Kwack K
- KMID: 2166419
- Genomics Inform.
- 2008 Dec;6(4):192-201.
Erythropoietin-producing human hepatocellular carcinoma receptor B1 (EPHB1) is a member of the Eph family of receptor tyrosine kinases that mediate vascular system development. Eph receptor overexpression has been observed in... -
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- Polymorphisms in RAS Guanyl-releasing Protein 3 are Associated with Chronic Liver Disease and Hepatocellular Carcinoma in a Korean Population
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Oh AR, Lee SK, Kim MH, Cheong JY, Cho SW, Yang KS, Kwack K
- KMID: 2166418
- Genomics Inform.
- 2008 Dec;6(4):181-191.
RAS guanyl-releasing protein 3 (RasGRP3), a member of the Ras subfamily of GTPases, functions as a guanosine triphosphate (GTP)/guanosine diphosphate (GDP)-regulated switch that cycles between inactive GDP- and active GTP-bound... -
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- Comparison of Normalization Methods for Defining Copy Number Variation Using Whole-genome SNP Genotyping Data
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Kim JH, Yim SH, Jeong YB, Jung SH, Xu HD, Shin SH, Chung YJ
- KMID: 2166424
- Genomics Inform.
- 2008 Dec;6(4):231-234.
Precise and reliable identification of CNV is still important to fully understand the effect of CNV on genetic diversity and background of complex diseases. SNP marker has been used frequently... -
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