- Are Mutations of the EGFR Gene Promising Predictive Markers for Anti-EGFR mAbs in Colorectal Carcinomas?
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Park DG
- KMID: 2198755
- J Korean Soc Coloproctol.
- 2011 Jun;27(3):103-104.
- doi: 10.3393/jksc.2011.27.3.103
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- Mechanisms of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance and Strategies to Overcome Resistance in Lung Adenocarcinoma
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Chang YS, Choi CM, Lee JC
- KMID: 2365316
- Tuberc Respir Dis.
- 2016 Oct;79(4):248-256.
- doi: 10.4046/trd.2016.79.4.248
Somatic mutations that lead to hyperactivation of epidermal growth factor receptor (EGFR) signaling are detected in approximately 50% of lung adenocarcinoma in people from the Far East population and tyrosine... -
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- Immunohistochemical Classification of Primary and Secondary Glioblastomas
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Lee KS, Choe G, Nam KH, Seo AN, Yun S, Kim KJ, Cho HJ, Park SH
- KMID: 2012155
- Korean J Pathol.
- 2013 Dec;47(6):541-548.
BACKGROUND: Glioblastomas may develop de novo (primary glioblastomas, P-GBLs) or through progression from lower-grade astrocytomas (secondary glioblastomas, S-GBLs). The aim of this study was to compare the immunohistochemical classification of... -
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- EGFR Tyrosine Kinase Inhibitors for NSCLC
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Kim YC
- KMID: 1881512
- J Lung Cancer.
- 2005 Dec;4(2):71-73.
The EGFR Tyrosine kinase inhibitors (TKIs) show significant clinical benefit in selected population with no smoking history, adenocarcinoma or mutations in EGFR gene. Mutations of K-ras gene are associated with... -
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- Role of Epidermal Growth Factor Receptor and the HER-2 Gene in Hormone Refractory Prostate Cancer
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Cho KS, Kim DJ, Lee JS, Cho NH, Park K, Ham WS, Choi YD
- KMID: 2312032
- Korean J Urol.
- 2008 Jan;49(1):24-30.
PURPOSE: Amplification and mutation of the epidermal growth factor receptor(EGFR) and HER-2 genes were analyzed in the tissues of hormone refractory prostate cancer(HRPC) patients. MATERIALS AND METHODS: Gene amplifications of the... -
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- Association between EGF and EGFR Gene Polymorphisms and Susceptibility to Alopecia Areata in the Korean Population
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Won YY, Haw S, Chung JH, Lew BL, Sim WY
- KMID: 2451497
- Ann Dermatol.
- 2019 Aug;31(4):489-492.
- doi: 10.5021/ad.2019.31.4.489
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- Neuroepithelial Tumor Relevant Genes
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Lee HC, Kim DW, Choi IJ, Lee JC, Son EI, Yim MB, Kim IH
- KMID: 1673073
- J Korean Neurosurg Soc.
- 1994 Aug;23(8):924-931.
Cancer may be a disease of genes, arising from genetic damage of diverse sorts-recessive and dominant mutations, large rearrangement of DNA and gene translocation on chromosomes, all leading to distorisions... -
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- Gefitinib Treatment for Pulmonary Sarcomatoid Carcinoma Driven by an EGFR Mutation: Two Cases
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Kim JY, Lim Y, Lee E, Kim MS, Lee DW, Kim TM, Lee SH
- KMID: 1833860
- Korean J Med.
- 2013 Mar;84(3):446-451.
- doi: 10.3904/kjm.2013.84.3.446
Sarcomatoid carcinoma of the lung is defined as a group of poorly differentiated non-small cell carcinomas that contain a component of sarcoma or a sarcoma-like element. Most sarcomatoid carcinomas are... -
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- Peptide Nucleic Acid Clamping Versus Direct Sequencing for the Detection of EGFR Gene Mutation in Patients with Non-small Cell Lung Cancer
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Yoon SH, Choi YD, Oh IJ, Kim KS, Choi H, Chang J, Shin HJ, Park CK, Kim YC
- KMID: 2403384
- Cancer Res Treat.
- 2015 Oct;47(4):661-669.
- doi: 10.4143/crt.2014.282
PURPOSE: Direct sequencing (DS) is the standard method for detection of epidermal growth factor receptor (EGFR) gene mutation in non-small cell lung cancer (NSCLC); however, low detection sensitivity is a... -
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- Mutational Analysis of the Epidermal Growth Factor Receptor Gene in Gastrointestinal Stromal Tumors
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Yoo NJ, Lee JW, Soung YH, Jeon HM, Nam SW, Kim SY, Park WS, Lee JY, Lee SH
- KMID: 2372342
- J Korean Gastric Cancer Assoc.
- 2004 Dec;4(4):268-271.
PUPOSE: Most gastrointestinal stromal tumors (GISTs) have gain-of-function mutations of the KIT or the platelet-derived growth factor receptor alpha (PDGFRA) genes, but approximately 10% of the GISTs are wild types... -
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- Molecular Diagnosis in Lung Cancer
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Lee KY
- KMID: 2200022
- J Lung Cancer.
- 2010 Jun;9(1):9-14.
- doi: 10.6058/jlc.2010.9.1.9
The advent of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib and erlotinib has opened a new horizon for the therapeutic options for patients with advanced lung cancer.... -
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- Association Study of Polymorphisms of Epidermal Growth Factor and Epidermal Growth Factor Receptor With Benign Prostatic Hyperplasia in a Korean Population
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Kim SK, Park HK, Choi HS, Yoo KH, Chung JH
- KMID: 2365703
- Int Neurourol J.
- 2016 Dec;20(4):363-370.
- doi: 10.5213/inj.1632538.269
PURPOSE: Recent studies have suggested that specific single-nucleotide polymorphisms (SNPs) contribute to the clinical features of benign prostatic hyperplasia (BPH). In this study, we investigated the relationships of genetic polymorphisms... -
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- Cyto - molecular Biologic Characterization of c - myc , erb B and EGF - Receptor in Squamous Cell Carcinoma
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Lee KS, Choi YY, Song JY, Choi IJ, Jang SI, Baek WK, Suh MH
- KMID: 2230813
- Korean J Dermatol.
- 1994 Apr;32(2):223-233.
BACKGROUND: Oncogenes and EGF-Receptor(EGFR) may be involved n different stages of the multistep carcinogenesis process. A specific pattern of karyotypic abnormalities in solid tumors can be detected by cytogenetic methods. OBJECTIVE:... -
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- Increased expression of the epidermal growth factor receptor gene in psoriasis
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Choi YY, Lee KS, Lee SS, Chang ES, Song JY
- KMID: 2303592
- Korean J Dermatol.
- 1992 Aug;30(4):431-438.
Psoriasis is characterized by disregulation of keratinocyte growth with profound epidermal hyperplasia. Keratinocyte hyperplasia in psoriasis may be expained in part by overproduction of growth factor, and by altered metabolism... -
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- Screening of Epidermal Growth Factor Receptor Gene Mutation in Non-Small Cell Lung Cancer Using a PCR-Based Enzymatic Digestion Method
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Jung YJ, Park SJ, Lee SB, Kim YT, Park JY, Park IK, Kang CH, Kim JH
- KMID: 2199833
- J Lung Cancer.
- 2012 Dec;11(2):77-83.
- doi: 10.6058/jlc.2012.11.2.77
PURPOSE: We applied a simplified method using polymerase chain reaction (PCR)-based enzymatic digestion for the detection of epidermal growth factor receptor (EGFR) mutation. MATERIALS AND METHODS: We selected 74 samples of... -
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- Clinicopathologic Analysis of Epidermal Growth Factor Receptor Status in Non-small Cell Lung Cancer: Protein Expression, Gene Amplification and Survival Analysis
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Lee S, Choi J, Jang SJ
- KMID: 1521612
- Korean J Pathol.
- 2007 Dec;41(6):387-392.
BACKGROUND: Abnormal over-expression or gene amplification of epidermal growth factor receptor (EGFR) is important in the prognosis of non-small cell lung cancer (NSCLC). We investigated the frequency of EGFR protein... -
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- The EGFR Protein Expression and the Gene Copy Number Changes in Renal Cell Carcinomas
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Lee S, An J, Kim A, Kim YS, Kim I, Genitourinary Pathology Study Group
- KMID: 1472619
- Korean J Pathol.
- 2009 Oct;43(5):413-419.
- doi: 10.4132/KoreanJPathol.2009.43.5.413
BACKGROUND: The epidermal growth factor receptor (EGFR) is known to be involved in many tumor promoting activities. EGFR inhibition has been tried as a therapeutic modality in many human malignancies. METHODS:... -
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- EGFR Gene Amplification and Protein Expression in Invasive Ductal Carcinoma of the Breast
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Hwangbo W, Lee JH, Ahn S, Kim S, Park KH, Kim CH, Kim I
- KMID: 2277454
- Korean J Pathol.
- 2013 Apr;47(2):107-115.
BACKGROUND: The epidermal growth factor receptor (EGFR) is a surrogate marker for basal-like breast cancer. A recent study suggested that EGFR may be used as a target for breast cancer... -
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- Intron 1 Polymorphism, Mutation and the Protein Expression of Epidermal Growth Factor Receptor in Relation to the Gefitinib Sensitivity of Korean Lung Cancer Patients
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Kim MJ, Shin KC, Lee KH
- KMID: 1472635
- Korean J Pathol.
- 2009 Dec;43(6):509-516.
- doi: 10.4132/KoreanJPathol.2009.43.6.509
BACKGROUND: Epidermal growth factor receptor (EGFR) intron 1 polymorphism in non-small cell lung cancer (NSCLC) has been found to have therapeutic implications for the patients treated with EGFR tyrosine kinase... -
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- PET Imaging-Based Phenotyping as a Predictive Biomarker of Response to Tyrosine Kinase Inhibitor Therapy in Non-small Cell Lung Cancer: Are We There Yet?
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Gerbaudo V, Kim CK
- KMID: 2373450
- Nucl Med Mol Imaging.
- 2017 Mar;51(1):3-10.
- doi: 10.1007/s13139-016-0453-6
The increased understanding of the molecular pathology of different malignancies, especially lung cancer, has directed investigational efforts to center on the identification of different molecular targets and on the development... -
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