- APC Mutation Spectra in Sporadic Colon Cancer Tissue among Korean
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Cho SH, Huh JW, Kim YJ, Shin MG, Kim HR
- KMID: 2096538
- J Korean Surg Soc.
- 2009 Mar;76(3):159-167.
- doi: 10.4174/jkss.2009.76.3.159
PURPOSE: APC (adenomatous polyposis coli) gene is one of the tumor-suppressor genes that acts in the early stages of cancer. Among general colon cancer patients, normal APC gene expression is... -
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- Relation between Loss of Heterozygosity of APC gene and: Catenin Expression in Gastric Cancer
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Kim JK, Moon SB, Choo KY, Park SH, Choi MG, Han JY, Chung KW, Sun HS
- KMID: 1857606
- Korean J Gastroenterol.
- 2000 Jun;35(6):724-731.
BACKGROUND/AIMS: Wide-type Adenomatous polyposis coli (APC) gene binds to beta-catenin and APC mutants lead to cytosolic accumulation of beta-catenin which serves as a component of carcinogenesis. We investigated the relationship... -
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- Expression of beta-catenin and Adenomatous Polyposis Coli(APC) Protein in Squamous Cell Carcinoma of the Laryngeal Cancers
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Park H, Kim HJ, Park JG, Kim DW, Lee BD, Chang HS
- KMID: 2276366
- Korean J Otolaryngol-Head Neck Surg.
- 2005 Mar;48(3):352-356.
BACKGROUND AND OBJECTIVES: beta-catenin has an essential role in intercellular adhesion and signal transduction. The Adenomatous poliposis coli (APC) protein interacts with beta-catenin in a multi-protein complex to regulate the... -
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- Loss of Heterozygosity Affecting the APC and p53 Tumor Suppressor Gene Loci in Colorectal Cancers and Its Prognostic Significance
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Chang ED, Park WS, Kim BK, Kim SM, Shim SI
- KMID: 1725225
- Korean J Pathol.
- 1997 Mar;31(3):191-200.
Development of the human colorectal cancer is associated with several distinct genetic abnormalities involving both dominant-acting oncogenes (K-ras, c-src) and tumor suppressor genes (APC, DCC, p53) which undergo inactivation or... -
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- Adenomatous Polyposis Coli and Ras Association Domain Family 1A Gene Methylation in Breast Cancer Patients
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Park IK, Yim JS, Ra YM, Ko DG, Choi IS, Choi WJ, Yoon DS
- KMID: 1745052
- J Breast Cancer.
- 2007 Jun;10(2):120-126.
- doi: 10.4048/jbc.2007.10.2.120
PURPOSE: Of the many carcinogenic mechanisms, DNA methylation is a strong factor in various cancers, including cancer of the breast. The genes related to breast cancer include 14.3.3 sigma, Cyclin... -
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- A Novel Adenomatous Polyposis Coli Gene Mutation of Cribriform-Morular Variant Papillary Thyroid Carcinoma: A Case Report
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Kim HJ, Choi N, Chung MK
- KMID: 2442064
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Mar;62(3):192-196.
- doi: 10.3342/kjorl-hns.2017.00759
Cribriform-morular variant papillary thyroid carcinoma (CMV-PTC) is a rare cancer that may arise in patients with familial adenomatous polyposis (FAP). Adenomatous polyposis coli (APC) gene mutation is associated with FAP,... -
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- Epigenetic Changes (Aberrant DNA Methylation) in Colorectal Neoplasia
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Kim YS, Deng G
- KMID: 2284042
- Gut Liver.
- 2007 Jun;1(1):1-11.
Both genetic and epigenetic events have been implicated in the stepwise histological progression involving adenoma-carcinoma and hyperplastic polyp/serrated adenoma-carcinoma sequences in the development of colorectal cancer. Genetic changes have been... -
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- A Novel Germline Mutation in Exon 15 of the APC Gene in Attenuated Familial Adenomatous Polyposis: A Report of Two Cases
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Jahng J, Yoon SJ, Park H
- KMID: 2053526
- Gut Liver.
- 2013 Jan;7(1):120-125.
Attenuated familial adenomatous polyposis (AFAP) is a variant of familial adenomatous polyposis with fewer than one hundred colorectal polyps and a later age of onset of the cancer. Here, we... -
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- A Case of Thyroid Papillary Cancer Associated with Familial Adenomatous Polyposis
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Shin SJ, Lee HJ, Kim SH, Shim WS, Lee S, Kim YM, Rhee Y, Kim TI, Cha BS, Lee HC, Lim SK
- KMID: 1837628
- J Korean Soc Endocrinol.
- 2004 Apr;19(2):209-216.
Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome, typically characterized by multiple colorectal adenomas and increased incidence of colorectal carcinomas if left untreated. It is caused by germline mutations... -
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- A Novel Germline Mutation of the APC Gene: A Case Report of Familial Adenomatous Polyposis Requiring Repeated Endoscopic Resections for Gastroduodenal Polyps
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Lee JH, Jang JW, Kim BW, Park ES, Kim SY
- KMID: 2383564
- Korean J Helicobacter Up Gastrointest Res.
- 2016 Dec;16(4):226-229.
- doi: 10.7704/kjhugr.2016.16.4.226
Familial adenomatous polyposis (FAP) is a precancerous clinical entity, which is characterized by the development of numerous adenomatous polyps throughout the colon and rectum. The majority of FAP are associated... -
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- Genetic Instability and Mutations of Mismatch Repair (MMR) and p53 Gene in Colorectal Cancers with Multiple Polyps and Sporadic Colorectal Cancers
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Chun SW, Chang SK
- KMID: 2334284
- J Korean Soc Coloproctol.
- 2002 Dec;18(6):353-362.
PURPOSE: General conceptions of carcinogenic mechanisms by recent reports are ras-p53 gene pathway in sporadic colorectal cancers (SCC), MMR gene pathway in hereditary nonpolyposis colorectal cancer (HNPCC) and APC gene... -
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- Molecular Pathogenesis of Gastric Cancer
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Park WS
- KMID: 2188286
- J Korean Med Assoc.
- 2010 Apr;53(4):270-282.
- doi: 10.5124/jkma.2010.53.4.270
In this article, I will survey the major genetic susceptibility and somatic genetic alterations involved in gastric cancer and adenoma. These include germline and somatic genetic alterations in oncogenes, tumor... -
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- Clinicopathological Analysis of Suspicious Attenuated Adenomatous Polyposis Coli
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Lee DH, Ahn BY, Jeong CS, Kim HC, Yu CS, Yang SK, Min YI, Kang KH, Kim JC
- KMID: 1944772
- J Korean Soc Coloproctol.
- 1999 Dec;15(5):417-426.
Familial adenomatous polyposis (FAP) is an inherited autosomal dominant syndrome caused by germ-line mutations of the adenomatous polyposis coli (APC) gene. Clinical diagnosis of familial adenomatous polyposis is usually based... -
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- Clinical Analysis for 30 Cases of Total or Subtotal Abdominal Colectomy and Total Proctocolectomy
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Lee JH, Lee IK, Oh ST, Jin HM, Chang SK
- KMID: 2199272
- J Korean Soc Coloproctol.
- 2004 Apr;20(2):93-98.
PURPOSE: A total or a subtotal abdominal colectomy and a total proctocolectomy are performed occasionally for the surgical treatment of familial adenomatous polyposis, multiple colorectal cancers, ulcerative colitis, acute... -
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- Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm
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Yoon H, Kim N, Shin CM, Lee HS, Kim BK, Kang GH, Kim JM, Kim JS, Lee DH, Jung HC
- KMID: 2363967
- Gut Liver.
- 2016 Mar;10(2):228-236.
- doi: 10.5009/gnl14472
BACKGROUND/AIMS: To identify the risk factors for metachronous gastric neoplasms in patients who underwent an endoscopic resection of a gastric neoplasm. METHODS: We prospectively collected clinicopathologic data and measured the methylation... -
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