- Angiotensin II and TGF-β1 Induce Alterations in Human Amniotic Fluid-Derived Mesenchymal Stem Cells Leading to Cardiomyogenic Differentiation Initiation
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GasiÅ«nienÄ— M, Petkus G, MatuzeviÄius D, Navakauskas D, NavakauskienÄ— R
- KMID: 2465896
- Int J Stem Cells.
- 2019 Jul;12(2):251-264.
- doi: 10.15283/ijsc18126
BACKGROUND AND OBJECTIVES: Human amniotic fluid-derived mesenchymal stem cells (AF-MSCs) may be a valuable source for cardiovascular tissue engineering and cell therapy. The aim of this study is to verify... -
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- Oculodentodigital Dysplasia Presenting as Spastic Paraparesis: The First Genetically Confirmed Korean Case and a Literature Review
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Park KW, Ryu HS, Kim J, Chung SJ
- KMID: 2395013
- J Mov Disord.
- 2017 Sep;10(3):149-153.
- doi: 10.14802/jmd.17050
Oculodentodigital dysplasia (ODDD) is a rare autosomal dominant inherited disease caused by mutations of the human gap junction alpha 1 gene, which encodes the protein Connexin-43. Patients with ODDD may... -
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- Long Term Speech Perception Outcomes of Cochlear Implantation in Gap Junction Protein Beta 2 Related Hearing Loss
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Kim SH, Nepali R, Yoo MH, Lee KS, Chung JW
- KMID: 2386988
- J Audiol Otol.
- 2017 Jul;21(2):95-102.
- doi: 10.7874/jao.2017.21.2.95
BACKGROUND AND OBJECTIVES: The mutation of the gap junction protein beta 2 (GJB2) gene is the predominant cause of autosomal recessive non-syndromic hearing loss. The purpose of this study was... -
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- Expression of Connexin 43 in the Myocardium in Sudden Unexplained Nocturnal Death Syndrome
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Huh GY, Ahn JW, Kim EY
- KMID: 2165004
- Korean J Leg Med.
- 2016 May;40(2):33-38.
- doi: 10.7580/kjlm.2016.40.2.33
Sudden unexplained nocturnal death syndrome (SUNDS) occurs predominantly in Southeast Asian people including Koreans. SUNDS is problematic for forensic pathologists because the diagnosis depends on the "exclusion of diagnosis." Moreover,... -
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- Gap junction blockage promotes cadmium-induced apoptosis in BRL 3A derived from Buffalo rat liver cells
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Hu D, Zou H, Han T, Xie J, Dai N, Zhuo L, Gu J, Bian J, Yuan Y, Liu X, Liu Z
- KMID: 2363336
- J Vet Sci.
- 2016 Mar;17(1):63-70.
- doi: 10.4142/jvs.2016.17.1.63
Gap junctions mediate direct communication between cells; however, toxicological cascade triggered by nonessential metals can abrogate cellular signaling mediated by gap junctions. Although cadmium (Cd) is known to induce apoptosis... -
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- Spinal Gap Junction Channels in Neuropathic Pain
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Jeon YH, Youn DH
- KMID: 2151665
- Korean J Pain.
- 2015 Oct;28(4):231-235.
- doi: 10.3344/kjp.2015.28.4.231
Damage to peripheral nerves or the spinal cord is often accompanied by neuropathic pain, which is a complex, chronic pain state. Increasing evidence indicates that alterations in the expression and... -
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- Effect of Mefloquine, a Gap Junction Blocker, on Circadian Period2 Gene Oscillation in the Mouse Suprachiasmatic Nucleus Ex Vivo
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Koo J, Choe HK, Kim HD, Chun SK, Son GH, Kim K
- KMID: 2407088
- Endocrinol Metab.
- 2015 Sep;30(3):361-370.
- doi: 10.3803/EnM.2015.30.3.361
BACKGROUND: In mammals, the master circadian pacemaker is localized in an area of the ventral hypothalamus known as the suprachiasmatic nucleus (SCN). Previous studies have shown that pacemaker neurons in... -
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- Cordblood-Based High-Throughput Screening for Deafness Gene of 646 Newborns in Jinan Area of China
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Li SX, Chen DL, Zhao SB, Guo LL, Feng HQ, Zhang XF, Ping LL, Yang ZM, Sun CX, Yao GD
- KMID: 2117514
- Clin Exp Otorhinolaryngol.
- 2015 Sep;8(3):211-217.
- doi: 10.3342/ceo.2015.8.3.211
OBJECTIVES: Infants with slight/mild or late-onset hearing impairment might be missed in universal newborn hearing screening (UNHS). We identified the mutation hot spot of common deaf gene in the newborns... -
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- Bisphenol A and 4-tert-Octylphenol Inhibit Cx46 Hemichannel Currents
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Oh S
- KMID: 2071822
- Korean J Physiol Pharmacol.
- 2015 Jan;19(1):73-79.
- doi: 10.4196/kjpp.2015.19.1.73
Connexins (Cx) are membrane proteins and monomers for forming gap junction (GJ) channels. Cx46 and Cx50 are also known to function as conductive hemichannels. As part of an ongoing effort... -
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- The Significance of Interstitial Cells in Neurogastroenterology
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Blair PJ, Rhee PL, Sanders KM, Ward SM
- KMID: 2381189
- J Neurogastroenterol Motil.
- 2014 Jul;20(3):294-317.
Smooth muscle layers of the gastrointestinal tract consist of a heterogeneous population of cells that include enteric neurons, several classes of interstitial cells of mesenchymal origin, a variety of immune... -
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- Erythrokeratodermia Variabilis Showing Gradual Disappearance of Erythema
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Kim H, Park IH, Kang JN, Seol JE, Sung HS
- KMID: 1802079
- Korean J Dermatol.
- 2014 Apr;52(4):260-263.
Erythrokeratodermia variabilis is an autosomal-dominant inherited disease associated with a mutation in gap junction beta (GJB) 3 and 4. It shows two characteristic features: migratory and irregularly shaped erythematous lesions... -
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- Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir
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Hu C, Chen Z, Zhao W, Wei L, Zheng Y, He C, Zeng Y, Yin B
- KMID: 2170650
- Biomol Ther.
- 2014 Mar;22(2):114-121.
Refractoriness of acute myeloid leukemia (AML) cells to chemotherapeutics represents a major clinical barrier. Suicide gene therapy for cancer has been attractive but with limited clinical efficacy. In this study,... -
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- Mouse Models for the Evaluation of Osteocyte Functions
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Komori T
- KMID: 2391953
- J Bone Metab.
- 2014 Feb;21(1):55-60.
Osteocytes establish an extensive intracellular and extracellular communication system via gap junction-coupled cell processes and canaliculi, through which cell processes pass throughout bone, and the communication system is extended to... -
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- Replication of the Association of the 6q22.31c Locus near GJA1 with Pulse Rate in the Korean Population
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Kim NH, Kim YJ, Oh JH, Cho YS
- KMID: 2166492
- Genomics Inform.
- 2012 Jun;10(2):106-109.
- doi: 10.5808/GI.2012.10.2.106
Pulse rate is known to be related to diverse phenotypes, such as cardiovascular diseases, lifespan, arrhythmia, hypertension, lipids, diabetes, and menopause. We have reported two genomewide significant genetic loci responsible... -
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- Gap Junction Contributions to the Goldfish Electroretinogram at the Photopic Illumination Level
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Kim DY, Jung CS
- KMID: 1768017
- Korean J Physiol Pharmacol.
- 2012 Jun;16(3):219-224.
- doi: 10.4196/kjpp.2012.16.3.219
Understanding how the b-wave of the electroretinogram (ERG) is generated by full-field light stimulation is still a challenge in visual neuroscience. To understand more about the origin of the b-wave,... -
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- Sex- and Age-Related Changes in Connexin 43 Expression in Normal Rat Bladder
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Song SH, Joo HT, Cho HW, Hwang HW, Lee KH, Kim DK
- KMID: 2232788
- Int Neurourol J.
- 2011 Mar;15(1):25-28.
PURPOSE: Gap junctions are intercellular channels to facilitate electrical and metabolic communication between adjacent cells. Connexin 43 is the most predominant type of connexin expressed on rat detrusor muscle cells.... -
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- Regulation of Gap Junctional Intercellular Communication in Human Keratinocyte Cells
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Kahng HS, Kim BC, Kang SO, Hong JJ, Jun HJ, Choung YH
- KMID: 1455600
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2010 Nov;53(11):675-685.
- doi: 10.3342/kjorl-hns.2010.53.11.675
BACKGROUND AND OBJECTIVES: Unlike the normal skin, cholesteatomas characterized by hyperproliferative keratinocytes exhibits up-regulation of connexins (Cxs) and gap junctional intercellular communication (GJIC). Currently, there are no appropriate clinical methods... -
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- Changes in transcript and protein levels of calbindin D28k, calretinin and parvalbumin, and numbers of neuronal populations expressing these proteins in an ischemia model of rat retina
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Kim SA, Jeon JH, Son MJ, Cha J, Chun MH, Kim IB
- KMID: 2168877
- Anat Cell Biol.
- 2010 Sep;43(3):218-229.
- doi: 10.5115/acb.2010.43.3.218
Excessive calcium is thought to be a critical step in various neurodegenerative processes including ischemia. Calbindin D28k (CB), calretinin (CR), and parvalbumin (PV), members of the EF-hand calcium-binding protein family,... -
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- Upregulation of Connexin43 Expression in Mitral Valves in a Rabbit Model of Hypercholesterolemia
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Kwon JB, Park CB, Sa YJ, Kim YD, Moon SW, Kim CK
- KMID: 2289071
- Korean J Thorac Cardiovasc Surg.
- 2010 Aug;43(4):356-363.
BACKGROUND: Connexin 43-mediated gap junctional communication plays an important role in atherosclerosis. Numerous studies have demonstrated a correlation between mitral valve annular calcification and atherosclerotic disease. However, the relevance of... -
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- In Silico Study of Human Gap Junction Beta-2 Protein by Homology Modeling
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Shehzadi A, Masood K
- KMID: 2166480
- Genomics Inform.
- 2010 Jun;8(2):70-75.
Asp66his, Asp54Lys, and Asp50Asn are mutations in connexin 26 that are observed in the clinic and give rise to autosomal dominant syndromes. They are the result of point mutations in... -
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