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Neuroprotective Strategies for Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review

Budihardja BM, Anggraini E, Pratiwi RW, Nastiti AD, Nusanti S

Purpose: Nonarteritic anterior ischemic optic neuropathy (NAION) is the second most common form of optic neuropathy. Most patients show no improvement over time. Until now, there is still no definitive...
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Effects of Calcium Dobesilate on Inner Retinal Thickness in Severe Non-proliferative Diabetic Retinopathy

Hwang DDJ

Purpose: To investigate the effect of calcium dobesilate on inner macular thickness measured with optical coherence tomography in the eyes with severe non-proliferative diabetic retinopathy (NPDR). Methods: The study participants were...
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Regenerative Effect of Adipose Derived Mesenchymal Stem Cells on Ganglion Cells in the Hypoxic Organotypic Retina Culture

Dov MB, Krief B, Benhamou M, Klein A, Schwartz S, Loewenstein A, Barak A, Barzelay A

Background and Objectives: To examine whether ischemic retinal ganglion cells (RGCs) will be salvaged from cell death by human adipose-derived mesenchymal stem cells (ADSCs) in an organotypic retina model. Methods and...
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Prognostic Factors for Visual Outcomes in Acute Anterior Optic Neuritis Using Optical Coherence Tomography

Park HY, Hong S, Kim S

Purpose: To identify the clinical characteristics and predictors of visual outcomes in acute anterior optic neuritis patients treated with high-dose steroid pulse therapy using spectral domain optical coherence tomography (SD-OCT). Methods:...
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Effect of caffeine on genes expressions of developing retinas in the chick model

Lekchaoum T, Buddawong A, Ahi S, Chandee N, Weerachatyanukul W, Asuvapongpatana S

It has been reported that overconsumption of caffeine during pregnancy leads to a deleterious effect within the nervous tissues during embryonic development. In this study, we further extrapolated the effect...
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Analysis of the Changes in Retinal Thickness in Eyes Undergoing Vitrectomy with Silicone Oil Tamponade

Kim JH, Yoon YS, Woo JM, Min JK

Purpose: To investigate changes in the retinal layer thickness in rhegmatogenous retinal detachment (RRD) and intraocular foreign body (IOFB) patients undergoing successful pars plana vitrectomy (PPV) with silicone oil tamponade....
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Contrast Sensitivity and Inner Retinal Layer Thickness Analysis of Type 2 Diabetic Patients Without Retinopathy

Lee KY, Shin SJ, Moon JS

Purpose: To compare the contrast sensitivities of type 2 diabetic patients without retinopathy and healthy subjects, and to assess the risk factors associated with a change in contrast sensitivity in...
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Longitudinal Changes in Layered Retinal Thickness during Axial Elongation in Healthy Myopic Eyes

Park MS, Lee KM, Kim M, Choung HK, Oh S, Kim SH

Purpose: To investigate longitudinal changes in foveal retinal sublayer thicknesses during axial elongation. Methods: From February 2013 to September 2014, a prospective cohort was established comprising pediatric patients aged < 13...
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Spike-triggered Clustering for Retinal Ganglion Cell Classification

Ahn J, Yoo Y, Goo YS

  • KMID: 2510506
  • Exp Neurobiol.
  • 2020 Dec;29(6):433-452.
  • doi: 10.5607/en20029
Retinal ganglion cells (RGCs), the retina’s output neurons, encode visual information through spiking. The RGC receptive field (RF) represents the basic unit of visual information processing in the retina. RFs...
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Age-related Changes of Macular Ganglion Cell-inner Plexiform Layer Thickness in Korean Elderly Subjects

Lee YJ, Yoo YJ, Han SB

Purpose: We sought to establish normative ranges of the ganglion cell-inner plexiform layer (GCIPL) thickness using spectral-domain optical coherence tomography in Korean elderly individuals and to identify factors that influence...
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Synchrony of Spontaneous Burst Firing between Retinal Ganglion Cells Across Species

Ahn J, Phan HL, Cha S, Koo Ki, Yoo Y, Goo YS

  • KMID: 2506533
  • Exp Neurobiol.
  • 2020 Aug;29(4):285-299.
  • doi: 10.5607/en20025
Neurons communicate with other neurons in response to environmental changes. Their goal is to transmit information to their targets reliably. A burst, which consists of multiple spikes within a short...
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A Comparison of Retinal Thickness Changes According to Initial Optic Disc Edema in Optic Neuritis Patients

Kim DS, Hong EH, Shin YU, Kang MH, Seong M, Cho HY

Purpose: To compare early changes in the macular retinal nerve fiber layer (mRNFL) and ganglion cell-inner plexiform layer (mGCIPL) thicknesses according to the severity of initial optic disc edema in...
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Pim-1 Protects Retinal Ganglion Cells by Enhancing Their Regenerative Ability Following Optic Nerve Crush

Zhang S, Shuai L, Wang D, Huang T, Yang S, Miao M, Liu F, Xu J

  • KMID: 2503984
  • Exp Neurobiol.
  • 2020 Jun;29(3):249-272.
  • doi: 10.5607/en20019
Provirus integration site Moloney murine leukemia virus (Pim-1) is a proto-oncogene reported to be associated with cell proliferation, differentiation and survival. This study was to explore the neuroprotective role of...
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Retinal Capillary Network in Fellow Eyes with Unilateral Vein Occlusion Using Optical Coherence Tomography Angiography

Jung WH, Kim JL

Purpose: To compare the thickness of the ganglion cell-inner plexiform layer (GCIPL) and the perifoveolar retinal capillary network between fellow eyes with unilateral branch retinal vein occlusion (BRVO) and healthy...
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Retinal Tissue Bioengineering, Materials and Methods for the Treatment of Glaucoma

Behtaj S, O¨ chsner A, Anissimov YG, Rybachuk M

BACKGROUND: Glaucoma, a characteristic type of optic nerve degeneration in the posterior pole of the eye, is a common cause of irreversible vision loss and the second leading cause of...
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New Features of Receptive Fields in Mouse Retina through Spike-triggered Covariance

Ahn J, Rueckauer , Yoo Y, Goo YS

Retinal ganglion cells (RGCs) encode various spatiotemporal features of visual information into spiking patterns. The receptive field (RF) of each RGC is usually calculated by spike-triggered average (STA), which is...
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Changes in the Ganglion Cell-inner Plexiform Layer after Consecutive Intravitreal Injections of Anti-vascular Endothelial Growth Factor in Age-related Macular Degeneration Patients

Kim SY, Yoon MH, Chin HS

PURPOSE: To investigate the effect of intravitreal anti-vascular endothelial growth factor (VEGF) injections on ganglion cell-inner plexiform layer (GCIPL) thickness in patients with age-related macular degeneration (AMD). METHODS: This retrospective study...
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Retinal Ganglion Cell Layer Thicknesses and Visual Functions in Patients with Bilateral Temporal Optic Atrophy

Kim BG, Park JY, Oh WH, Choi J

PURPOSE: To investigate correlations between macular retinal ganglion cell (RGC) layer thickness and best-corrected visual acuity (BCVA) and visual field parameters in patients with bilateral temporal optic atrophy. METHODS: Thirty eyes...
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Visual Field Changes after Internal Limiting Membrane Peeling in Glaucoma Patients with Epiretinal Membrane

Park HS, Ha SJ, Ahn JH

PURPOSE: To report visual field changes after internal limiting membrane (ILM) peeling for macular epiretinal membrane (ERM) according to the severity of glaucoma. METHODS: A retrospective review of 37 eyes from...
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Retinal Nerve Fiber Layer and Macular Retinal Ganglion Cell Layer Thicknesses in Healthy Korean Children

Kim Y, Hwang YH

PURPOSE: To measure the thicknesses of the circumpapillary retinal nerve fiber layer (RNFL) and macular retinal ganglion cell-inner plexiform layer (GCIPL) by optical coherence tomography (OCT) in healthy Korean children...
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