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Animal Models of Acute Hepatic Failure

Hwang SG

  • KMID: 2084977
  • Korean J Gastroenterol.
  • 2001 May;37(5):303-311.
Our understanding and treatment of acute hepatic failure have been limited by the lack of satisfactory animal models. The requirements for a satisfactory animal models are reversibility, reproducibility, death from...
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Correlation between synthesis of α2-macroglobulin as acute phase protein and degree of hepatopathy in rats

Ito R, Kuribayashi T

The degree of hepatopathy affecting the synthesis of α2-macroglobulin (α2M) as an acute phase protein in rats was investigated. Hepatopathy was induced in Sprague-Dawley rats by intravenous administration of galactosamine...
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The Effects of Acute Hepatic Failure by Galactosamine on Mivacurium-induced Neuromuscular Blockade in the Cats

Kim SY, Kim CG, Lim HK, Yoon KB

BACKGROUND: Though the mivacurium is the short acting nondepolarizing neuromuscular blocking agent, the action duration of it is not prospected in condition of hepatic failure owing to its being metabolized...
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The Effects of Cholestasis and Hepatic Failure on Mivacurium - induced Neuromuscular Blockade in the Cat

Choi MY, Park GY, Han JU, Lee SY, Shin YS

BACKGROUND: Duration of action varies in conditions with reduced plasma cholinesterase activity. To evaluate the action duration and recovery of mivacurium under the experimental hepatic failure and cholestasis, the pharmacodynamic...
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Luteolin and luteolin-7-O-glucoside protect against acute liver injury through regulation of inflammatory mediators and antioxidative enzymes in GalN/LPS-induced hepatitic ICR mice

Park CM, Song YS

BACKGROUND/OBJECTIVES: Anti-inflammatory and antioxidative activities of luteolin and luteolin-7-O-glucoside were compared in galactosamine (GalN)/lipopolysaccharide (LPS)-induced hepatitic ICR mice. MATERIALS/METHODS: Male ICR mice (6 weeks old) were divided into 4 groups: normal...
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The Effects of Cholestasis and Hepatic Failure on Vecuronium - induced Neuromuscular Blockade in the Cat

Lee KM, Kwak YR, Shin YS, Choi R, Kim JR

To determine th effects of experimental extrahepatic cholestasis in the pharmacodynamics of vecumnium, the author administered vecuronium 500 ug/kg intravenously to six normal cats(control group), and into each of six...
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