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Mirogabalin: could it be the next generation gabapentin or pregabalin?

Kim JY, Abdi S, Huh B, Kim KH

Except for carbamazepine for trigeminal neuralgia, gabapentinoid anticonvulsants have been the standard for the treatment of neuropathic pain. Pregabalin, which followed gabapentin, was developed with the benefit of rapid peak...
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All about pain pharmacology: what pain physicians should know

Kim KH, Seo HJ, Abdi S, Huh B

From the perspective of the definition of pain, pain can be divided into emotional and sensory components, which originate from potential and actual tissue damage, respectively. The pharmacologic treatment of...
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Trigeminal neuralgia management after microvascular decompression surgery: two case reports

Hwang V, Gomez-Marroquin E, Enciso R, Padilla M

Trigeminal neuralgia (TN) involves chronic neuropathic pain, characterized by attacks of repeating short episodes of unilateral shock-like pain, which are abrupt in onset and termination. Anticonvulsants, such as carbamazepine, are...
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Pregabalin and gabapentin in neuropathic pain management after spinal cord injury: a systematic review and meta-analysis

Davari M, Amani B, Amani B, Khanijahani A, Akbarzadeh A, Shabestan R

Neuropathic pain after spinal cord injury (SCI) has a significant negative impact on the patients’ quality of life. The objective of this systematic review is to examine the safety and...
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Gabapentin for the Treatment of Chronic Pelvic Pain Syndrome in Patients with High Pain Score

Cho S, Cho IR

PURPOSE: The underlying pathogenic mechanisms of chronic pelvic pain syndrome (CPPS) are unclear. A growing body of evidence suggests that the urogenital pain of CPPS may be neuropathic in origin....
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Successful Management of Clozapine-induced Akathisia with Gabapentin Enacarbil: A Case Report

Takeshima , Ishikawa H, Kikuchi Y, Kanbayashi T, Shimizu T

The management of clozapine (CLZ)-induced adverse events affects patient prognoses. Akathisia is a relatively rare adverse event related to CLZ administration and thus the management of this syndrome is not...
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Efficacy and Safety of Gabapentin in the Treatment of Chronic Cough: A Systematic Review

Shi G, Shen Q, Zhang C, Ma J, Mohammed A, Zhao H

Despite recent clinical guidelines, the optimal therapeutic strategy for the management of refractory chronic cough is still a challenge. The present systematic review was designed to assess the evidence for...
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Effects of pregabalin and gabapentin on postoperative pain and opioid consumption after laparoscopic cholecystectomy

Eidy M, Fazel MR, Abdolrahimzadeh H, Moravveji , Kochaki E, Mohammadzadeh M

BACKGROUND: Gabapentin and pregabalin are antiepileptic drugs that are also used for chronic pain treatment. This study evaluated the effects of pregabalin and gabapentin on postoperative pain in patients undergoing...
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Low doses of amitriptyline, pregabalin, and gabapentin are preferred for management of neuropathic pain in India: is there a need for revisiting dosing recommendations?

Kamble SV, Motlekar S, D'souza LL, Kudrigikar VN, Rao SE

BACKGROUND: Current therapy for the treatment of neuropathic pain is often unsatisfactory. Considerable variation in treatment pattern still exists in spite of availability of sufficient literature from various guidelines. Recent...
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Perioperative gabapentin as a component of multimodal analgesia for postoperative pain after total knee arthroplasty

Khuvtsagaan B, Lundeg G

BACKGROUND: Total knee arthroplasty (TKA) causes considerable postoperative pain. This study investigated the analgesic effects of gabapentin on postoperative pain in patients undergoing unilateral TKA in Mongolia. METHODS: The study randomly...
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Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled Trial

Qadeer M, Waqas M, Rashid MJ, Enam SA, Sharif S, Murtaza G

STUDY DESIGN: Randomized controlled trial. PURPOSE: The purpose of this study was to compare pregabalin and gabapentin for mean postoperative visual analog score (VAS) for pain in patients undergoing single-level lumbar...
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The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain

Kim MJ, Lee JH, Jang JU, Quan FS, Kim SK, Kim W

Paclitaxel, a chemotherapeutic drug, induces severe peripheral neuropathy. Gabapentin (GBT) is a first line agent used to treat neuropathic pain, and its effect is mediated by spinal noradrenergic and muscarinic...
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The Effectiveness of Oral Corticosteroids for Management of Lumbar Radiating Pain: Randomized, Controlled Trial Study

Ko S, Kim S, Kim J, Oh T

BACKGROUND: Although both pregabalin and gabapentin are known to be useful for treating lumbar radiating pain and reducing the incidence of surgery, the oral corticosteroids sometimes offer a dramatic effect...
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Painful legs and moving toes syndrome in a 16-year-old girl

Kim SS, Hwang YS, Kim YC

Painful legs and moving toes (PLMT) syndrome is characterized by spontaneous movements of the digits and pain in one or both lower extremities. Of the reported cases, a majority of...
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Post-traumatic Stress Disorder Symptoms in a Female Patient Following Repeated Teasing: Treatment with Gabapentin and Lamotrigine and the Possible Role of Sensitization

Kishimoto , Goto Y, Hashimoto

Post-traumatic stress disorder (PTSD) is a pathological response to trauma characterized by frequent recollections, recurrent nightmares, and flashbacks of the traumatic event(s). To date, the precise mechanisms underlying the development...
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Effect of Gabapentin for the Treatment of Burning Mouth Syndrome Comorbid with Depression in Postmenopausal Women

Kim MJ, Kim HS, Park SS

Burning mouth syndrome is characterized by intra-oral burning sensation without any organic abnormalities. This syndrome is associated with various etiological factors such as neuropathy, malnutrition, menopause and depression. Several medications...
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Analgesic Effect of Intrathecal Gabapentin in a Rat Model of Persistent Muscle Pain

Kang TW, Sohn MK, Park NK, Ko SH, Cho KJ, Beom J, Kang S

OBJECTIVE: To evaluate the analgesic effect of intrathecal gabapentin therapy on secondary hyperalgesia in a rat model of persistent muscle pain. METHODS: Intrathecal catheters were implanted into rats. Mechanical secondary hyperalgesia...
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Administration of four different doses of gabapentin reduces awakening from breakthrough pain and adverse effects in outpatients with neuropathic pain during the initial titration

Yang JY, Lee WI, Shin WK, Kim CH, Baik SW, Kim KH

BACKGROUND: Gabapentin is a safe and well-tolerated anticonvulsant with a wide therapeutic index, and it is used for neuropathic pain. The aim of this study was to compare previous dosing...
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Identification of Differentially Expressed Genes by Gabapentin in Cultured Dorsal Root Ganglion in a Rat Neuropathic Pain Model

Heo JH, Lee SH, Chang KH, Han EH, Lee SG, Choi DW, Kim SW

  • KMID: 1502514
  • Biomol Ther.
  • 2013 Mar;21(2):126-131.
Neuropathic pain is a chronic pain disorder caused by nervous system lesions as a direct consequence of a lesion or by disease of the portions of the nervous system that...
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The prophylactic effects of gabapentin on postoperative sore throat after thyroid surgery

Lee JH, Lee HK, Chun NH, So Y, Lim CY

BACKGROUND: Postoperative sore throat (POST) is considered a usual complication after tracheal intubation, especially, thyroid surgery. Gabapentin is a widely studied multimodal perioperative drug, which can be used to treat...
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