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Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled

Jung H, Kim HJ, Lee SK, Kim R, Kopachik W, Han JK, Jho EH

Wnt signaling is known to be important for diverse embryonic and post-natal cellular events and be regulated by the proteins Dishevelled and Axin. Although Dishevelled is activated by Wnt and...
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Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB

Shin H, Park SY, Lee KB, Shin E, Nam SW, Lee JY, Jang JJ

BACKGROUND/AIMS: This study aimed to better understand gene expression profiles of human hepatic stellate cell (HSC) activation and the relationship with the Wnt signaling pathway. METHODS: The global transcript levels...
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