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Effect of Osteoporosis Medication on Fracture Healing: An Evidence Based Review

Shin YH, Shin WC, Kim JW

A systematic search was conducted and relevant studies that evaluated the influence of osteoporosis medications (bisphosphonates [BPs], denosumab, selective estrogen receptor modulators [SERMs], recombinant human parathyroid hormone teriparatide [TPTD], and...
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Frozen-thawed gelatin-induced osteogenic cell sheets of canine adipose-derived mesenchymal stromal cells improved fracture healing in canine model

Yoon Y, Jung T, Afan Shahid M, Khan IU, Kim WH, Kweon OK

We assessed the efficacy of frozen-thawed gelatin-induced osteogenic cell sheet (FT-GCS) compared to that of fresh gelatin-induced osteogenic cell sheet (F-GCS) with adipose-derived mesenchymal stromal cells (Ad-MSCs) used as the...
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Effect of Preoperative Bisphosphonate Treatment on Fracture Healing after Internal Fixation Treatment of Intertrochanteric Femoral Fractures

Lim EJ, Kim JT, Kim CH, Kim JW, Chang JS, Yoon PW

PURPOSE: There are concerns that administration of bisphosphonate (BP) can substantially suppress bone turnover, potentially interfering with fracture healing. We investigated the effects of preoperative BP administration before internal fixation...
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The effects of pentoxifylline adminstration on fracture healing in a postmenopausal osteoporotic rat model

Vashghani Farahani MM, Ahadi R, Abdollahifar M, Bayat M

Previous studies report positive effects of pentoxifylline (PTX) alone or in combination with other drugs on some pathologic bone diseases as well as an ability to accelerate osteogensis and fracture...
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Current Role and Application of Teriparatide in Fracture Healing of Osteoporotic Patients: A Systematic Review

Kim SM, Kang KC, Kim JW, Lim SJ, Hahn MH

BACKGROUND: The use of osteoanabolic agents to facilitate fracture healing has been of heightened interest to the field of orthopaedic trauma. This study aimed to evaluate the evidence of teriparatide...
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Effects of Teriparatide Administration on Fracture Healing after Intramedullary Nailing in Atypical Femoral Fractures

Park CH, Shon OJ, Moon JJ, Shim BJ, Heo JH

PURPOSE: The purpose of this study is to evaluate the effects of teriparatide administration on fracture healing after intramedullary nailing in atypical femoral fractures. MATERIALS AND METHODS: We retrospectively reviewed 26...
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The Effect of Different Wavelength of Low Power Laser on Fracture Healing

Kim MH, Yoo MJ, Park HG, Rhee CK, Meng Y, Kim YJ, Hwang SS

  • KMID: 2023975
  • J Korean Orthop Res Soc.
  • 2007 Apr;10(1):1-9.
PURPOSE: The purpose of this study is to evaluate the effect of different wave length of low power laser on early fracture healing. METHODS AND MATERIALS: Nine week old female English...
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The Effect of Low Level Laser on the Fracture Healing in Guinea Pig Femur

Kim MH, Park HG, Rhee CK, Park KH, Park HK, Kim YJ

  • KMID: 2199119
  • J Korean Orthop Res Soc.
  • 2005 Apr;8(1):10-19.
PURPOSE: This study was conducted to evaluate the effectiveness of the low level laser on the fracture-healing of the guinea pig femurs. MATERIALS AND METHODS: This study was performed on 36...
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Effect of Smoking on Long Bone Shaft Fracture Healing

Bae SY, Kim HC, Roh JY, Lee DW

  • KMID: 2399092
  • J Korean Orthop Assoc.
  • 2004 Aug;39(4):366-372.
PURPOSE: To evaluate the effect of smoking on the union time of the long bone shaft fractures. MATERIALS AND METHODS: We retrospectively analysed eighty-four patients with a long bone shaft...
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The Influence of Androgen Deficiency and Osteopenia on Fracture Healing in Orchiectomized Rats

Choi JS, Lee CS, Shin JW, Jang YG, You SJ, Choi JM

  • KMID: 2399068
  • J Korean Orthop Assoc.
  • 2003 Oct;38(6):646-652.
PURPOSE: The purpose of this study was to evaluate the effect of testosterone deficiency and osteopenia on fracture healing using orchiectomized adult rats. MATERIALS AND METHODS: Fifty-two 3 month old...
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Animal Model and Gene Expression Analysis During the Accelerated Fracture Healing in Traumatic Brain Injury

Kim KH, Kim HS, Moon SH, Kim H, Kwon UH, Lee HM, Park HW, Hahn SB, Moon ES

  • KMID: 2104907
  • J Korean Orthop Res Soc.
  • 2003 Oct;6(2):177-185.
PURPOSE: This study was performed to create a traumatic brain injury (TBI) animal model of up-regulated bone formation, and to show the possibility of comprehensive analysis of early gene expression...
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Changes of Serum Alkaline Phosphatase and Osteocalcin during Fracture Healing

Lee HS, Lee CS, Jang JS, Lee JD, Um SM

  • KMID: 2105865
  • J Korean Orthop Assoc.
  • 2002 Jun;37(3):411-415.
PURPOSE: To investigate changes of serum osteoblastic marker during fracture healing. MATERIALS AND METHODS: The study included 22 patients with fresh fractures. Serum alkaline phosphatase (ALP), bone specific alkaline phosphatase and...
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Effect of the Ultrasound and LASER in the fracture healing in rabbits

Yang JY, Rhee KJ, Lee JK, Hwang DS, Shin HD, Lee JH

PURPOSE: To study the effectiveness of the ultrasound and LASER on the fracturehealing in rabbits. MATERIALS AND METHODS: This study was performed on rabbits using the Hi-Tech 2000 (Ultrasound+LASER) which was...
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The Effects of aging process on fracture healing in rat callus

Song SH, Choi YH, Gu SC, Yoo SH, Park YE

PURPOSE: Patient age significantly influences the rate of fracture healing. The rate of healing declines with increasing age. The authors compared the aging effect on fracture healing in the callus...
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Cellular Proliferation and Apoptosis during Endochondral Fracture Healing

Im GI, Kim DY, Shin JH, Han JD, Cho WH, Kim IS

  • KMID: 2189401
  • J Korean Orthop Assoc.
  • 1999 Oct;34(5):803-809.
PURPOSE: The authors investigated the process of endochondral ossification quantitatively and objectively in respect to proliferation and apoptosis. MATERIALS AND METHODS: Fractures were made on the left tibiae of 72...
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Effect of Intermittent Administration of Parathyroid Hormone on Fracture Healing in Ovariectomized Rats

Woo KH, Jahng JS

  • KMID: 2189558
  • J Korean Orthop Assoc.
  • 1999 Feb;34(1):207-217.
PURPOSE: This study was designed to compare fracture healing in normal and ovariectomized rat, and to evaluate the effect of intermittent administration of parathyroid hormone on fracture healing in osteopenic...
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The Effect of Distraction - Compression on the Fracture Healing in Rats with Osteoporosis

Park SE, Choi IH, Seong SC, Chung CY, Cho TJ, Sohn CS, Song KY

  • KMID: 2189684
  • J Korean Orthop Assoc.
  • 1998 Aug;33(4):1193-1198.
This study is verifying the hypothesis that distraction followed by recompression may promote fracture healing of the osteoporotic bone on the assumption that distraction induces increased callus formation at the...
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Temporal and Spatial Expression of Bone Morphogenetic Protein -2 and -4 mRNA in Distraction Osteogenesis and Fracture Healing

Cho TJ, Choi IH, Chung CY, Park SS, Park YK

  • KMID: 2336039
  • J Korean Orthop Assoc.
  • 1998 Jun;33(3):595-605.
Temporal and spatial expression of bmp-2 and bmp-4 was investigated in distraction osteogenesis and fracture healing models in order to delineate their roles in these new hone formation processes. Distraction...
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Stimulation of fracture Healing by Low-Intensity Pulsing Ultrasound

Yang KH, Choi CH, Cho JH

We performed a preliminary study to evaluate the effect of ultrasound in canine osteotomy model. Both ulna shafts were osteotomized and one side was irradiated with low-energy pulsing ultrasound, 50mW/cm2,...
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The Use of Ultrasound for the Early Evaluation of Evaluation of Fracture healing After Interlocking Nailing of the Tibia

Suh KT, Suh YH, Lee SH

  • KMID: 2336009
  • J Korean Orthop Assoc.
  • 1997 Oct;32(5):1232-1238.
After the stabilization using unreamed intramedullary interlocking nails for the management of fractures of the tibial shaft, a large percentage of patients whose fractures would proceed to delayed bony union...
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