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Association between Serum Folic Acid Level and the Risk of Atherosclerotic Cardiovascular Disease within 10 Years: The 7th (2016–2018) Korean National Health and Nutrition Examination Survey

Lee S, Yeo Y, Jeon KH, Yoo JH

Background: Folic acid regulates homocysteine metabolism, which is associated with the occurrence of cardiovascular diseases. We aimed to assess the relationship between folic acid level and the risk of atherosclerotic...
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Serum homocysteine concentration in dogs with immunosuppressant-responsive enteropathy

Benvenuti E, Pierini A, Gori E, Bottero E, Pietra M, Lippi I, Meucci V, Marchetti V

Background: Homocysteine (HCY) was evaluated in healthy and chronic enteropathic dogs, however no studies on dogs with immunosuppressant-responsive enteropathy are available. Objectives: The aim was to evaluate serum HCY concentrations and...
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Enzymes involved in folate metabolism and its implication for cancer treatment

Kim SE

BACKGROUND/OBJECTIVES: Folate plays a critical role in DNA synthesis and methylation. Intracellular folate homeostasis is maintained by the enzymes folylpolyglutamate synthase (FPGS) and γ-glutamyl hydrolase (GGH). FPGS adds glutamate residues...
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The Protective Effect of Maternal Folic Acid Supplementation on Childhood Cancer: A Systematic Review and Meta-analysis of Case-control Studies

Wan Ismail WR, Abdul Rahman R, Rahman NA, Atil A, Nawi AM

OBJECTIVES: Maternal folic acid supplementation is considered mandatory in almost every country in the world to prevent congenital malformations. However, little is known about the association of maternal folic acid...
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Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment

Jang S, Han JW, Shin J, Kim TH, Kwak KP, Kim K, Kim BJ, Kim SG, Kim JL, Kim TH, Moon SW, Park JY, Park JH, Byun S, Suh SW, Seo J, So Y, Ryu SH, Youn JC, Lee KH, Lee DY, Lee DW, Lee SB, Lee JJ, Lee JR, Jeong H, Jeong HG, Jhoo JH, Han K, Hong JW, Kim KW

OBJECTIVE: This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study. METHODS: We analyzed 3,910 participants whose serum...
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Folate food source, usual intake, and folate status in Korean adults

Kim YN, Cho YO

BACKGROUND/OBJECTIVES: The purposes of the study were to investigate folate intakes and plasma folate concentrations as well as estimate folate status in Korean healthy adults. SUBJECTS/METHODS: A total of 254 healthy...
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MTHFR 3′-untranslated region polymorphisms contribute to recurrent pregnancy loss risk and alterations in peripheral natural killer cell proportions

Kim ES, Kim JO, An HJ, Sakong JH, Lee HA, Kim JH, Ahn EH, Kim YR, Lee WS, Kim NK

OBJECTIVE: To identify the associations between polymorphisms of the 3′-untranslated region (UTR) of methylenetetrahydrofolate reductase (MTHFR) gene, which codes for an important regulatory enzyme primarily involved in folate metabolism, and...
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Development of Nutrition Education Contents for Pregnant Women Based on Effective Communication Strategies

Yoo T, Han YH, Kim JH, Lee MJ, Hyun T

OBJECTIVES: The purpose of the study was to develop communication strategies for effective nutrition education targeting pregnant women and to create nutrition education contents. METHODS: The format and the contents of...
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Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis

Park YM, Youn J, Cho CH, Kim SH, Lee JE

BACKGROUND/OBJECTIVES: The relationship between folate and colorectal neoplasia remains controversial. We examined the association between serum folate concentrations and colorectal adenomas in a case-control study of Korean adults and conducted...
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Status of serum vitamin B₁₂ and folate in patients with inflammatory bowel disease in China

Huang S, Ma J, Zhu M, Ran Z

BACKGROUND/AIMS: Inflammatory bowel disease (IBD) primarily involves the intestinal tract and can affect vitamin absorption. This study was designed to assess the prevalence of vitamin B₁₂ and folate deficiencies in...
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A Rare Case of Cerebral Sinovenous Thrombosis Associated with MTHFR A1298C and C677T Mutations

Kim SH, Lee NM, Chae SA

Neonatal cerebral sinovenous thrombosis (CSVT) is a rare disease with severe neurological sequelae. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate cycle, and mutations in MTHFR are associated...
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Elevated folic acid results in contrasting cancer cell line growth with implications for mandatory folic acid fortification

Yates Z, Lucock M, Veysey M, Choi JH

PURPOSE: The initiation of mandatory folic acid fortification using pteroylmonoglutamic acid (PteGlu) has reduced the rate of congenital malformations. However, it also appears to be responsible for several adverse effects,...
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Combined effect of folate and adiposity on homocysteine in children at three years of age

Cho SJ, Lee HA, Park BH, Ha EH, Kim YJ, Park EA, Park H

BACKGROUND/OBJECTIVES: Cardiovascular diseases is a major cause of death and is responsible for 23.8% of deaths in Korea. Clinical symptoms manifest in adulthood, but susceptibility begins in utero. Elevated homocysteine...
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Folate Receptor-Targeted Diagnostics and Therapeutics for Inflammatory Diseases

Yi YS

Inflammation, an innate immune response mediated by macrophages, forms the first line of defence to protect our body from the invasion of various pathogens. Although inflammation is a defensive response,...
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Synthesis and Evaluation of (99m)Tc-Labeled Folate-Tripeptide Conjugate as a Folate Receptor-Targeted Imaging Agent in a Tumor-Bearing Mouse Model

Kim MH, Kim WH, Kim CG, Kim DW

PURPOSE: The folate receptor (FR) is an attractive molecular target since it is overexpressed in a variety of human tumors. The purpose of the present study was to synthesize and...
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Dietary folate intake and food sources of children and adolescents in Chungcheong area - Using nutrient database revised by measured folate in selected foods

Kim JH, Lee E, Hyun T

PURPOSE: The purpose of this study was to estimate dietary folate intake and food sources of children and adolescents using a nutrient database revised based on measured folate in selected...
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Determinants of neural tube defect (NTD)-protective circulating concentrations of folate in women of child-bearing age in the US post-folic acid fortification era

Piyathilake C, Eom SY, Hyun T, Badiga S, Robinson C, Rahman N, Kim H, Johanning

  • KMID: 2313686
  • Nutr Res Pract.
  • 2013 Aug;7(4):315-325.
We evaluated folate status of child-bearing age women diagnosed with abnormal pap smear in the US post-folic acid (FA) fortification era and assessed the determinants of NTD-protective and supra-physiologic (SP)...
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Effects of parental folate deficiency on the folate content, global DNA methylation, and expressions of FRalpha, IGF-2 and IGF-1R in the postnatal rat liver

Mejos KK, Kim HW, Lim EM, Chang N

  • KMID: 2313681
  • Nutr Res Pract.
  • 2013 Aug;7(4):281-286.
We examined the effect of parental folate deficiency on the folate content, global DNA methylation, folate receptor-alpha (FRalpha), insulin-like-growth factor-2 (IGF-2) and -1 receptor (IGF-1R) in the liver and plasma...
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Intake and blood concentrations of folate and their association with health-related behaviors in Korean college students

Jang HB, Han YH, Piyathilake CJ, Kim H, Hyun T

  • KMID: 2313672
  • Nutr Res Pract.
  • 2013 Jun;7(3):216-223.
The purpose of this study is to assess folate intake, and serum and red blood cell (RBC) folate concentrations, and investigate the association between folate status and health-related behaviors among...
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Pulmonary thromboembolism due to severe hyperhomocysteinemia associated with a methyltetrahydrofolate reductase mutation

Cho KH, Jeong MH, Sim DS, Hong YJ, Kim JH, Ahn Y, Kang JC

No abstract available.
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