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A Fusion Protein of Derp2 Allergen and Flagellin Suppresses Experimental Allergic Asthma

Tan W, Zheng JH, Duong TM, Koh YI, Lee SE, Rhee JH

PURPOSE: The house dust mite (HDM) is one of the most important sources of indoor allergens and a significant cause of allergic rhinitis and allergic asthma. Our previous studies demonstrated...
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Enhancement of antigen-specific humoral immune responses and protein solubility through conjugation of bacterial flagellin, Vibrio vulnificus FlaB, to the N-terminus of porcine epidemic diarrhea virus surface protein antigen S0

Oh SH, Kim Cho YS, Lee HB, Lee SM, Kim WS, Hong L, Cho CS, Choi YJ, Kang SK

Porcine epidemic diarrhea (PED) is a highly contagious enteric swine disease. The large economic impact of PED on the swine industry worldwide has made the development of an effective PED...
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Flagellin Modulates the Function of Invariant NKT Cells From Patients With Asthma via Dendritic Cells

Shim JU, Rhee JH, Jeong JU, Koh YI

PURPOSE: Invariant natural killer T (iNKT) cells play a critical role in the pathogenesis of asthma. We previously reported the association between circulating Th2-like iNKT cells and lung function in...
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Tetanus toxin fragment C fused to flagellin makes a potent mucosal vaccine

Lee SE, Nguyen CT, Kim SY, Thi TN, Rhee JH

PURPOSE: Recombinant subunit vaccines provide safe and targeted protection against microbial infections. However, the protective efficacy of recombinant subunit vaccines tends to be less potent than the whole cell vaccines,...
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Intranasal immunization with a flagellin-adjuvanted peptide anticancer vaccine prevents tumor development by enhancing specific cytotoxic T lymphocyte response in a mouse model

Nguyen CT, Hong SH, Ung TT, Verma V, Kim SY, Rhee JH, Lee SE

PURPOSE: Human papillomavirus (HPV) is a significant cause of cervical cancer-related deaths worldwide. Because HPV is a sexually transmitted mucosal pathogen, enhancement of antigen-specific mucosal immune response likely serves good...
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TLR4, 5, and 9 Agonists Inhibit Murine Airway Invariant Natural Killer T Cells in an IL-12-Dependent Manner

Shim JU, Rhee JH, Koh YI

PURPOSE: Invariant natural killer T (iNKT) cells may play an important role in the pathogenesis of asthma in mice and humans. Thus, an agent that modulates the function of iNKT...
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Basic and Translational Understandings of Microbial Recognition by Toll-Like Receptors in the Intestine

Rhee SH

  • KMID: 2326186
  • J Neurogastroenterol Motil.
  • 2011 Jan;17(1):28-34.
Microbial recognition by multicellular organisms is initially accomplished by a group of pattern recognition receptors which are specialized to recognize microbe-associated molecular patterns (MAMPs) such as lipopolysaccharide, bacterial lipoprotein, CpG...
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A Bacterial Flagellin, Vibrio vulnificus FlaB, Induces Human Dendritic Cell Maturation

Jeong BC, Kim SY, Choi BH, Park MS, Lee JJ, Rhee JH, Lee SE

  • KMID: 1574163
  • J Bacteriol Virol.
  • 2005 Sep;35(3):209-216.
The motile marine bacterium, Vibrio vulnificus has a total of six flagellins. Flagellin is a structural component of flagellar filament in various locomotive bacteria and is the ligand of Toll-like...
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Effect of the Heat Shock Protein 70 on the Adjuvanticity Induced by a Bacterial Flagellin of Vibrio ulnificus

Lee SE, Bae SJ, Kim SY, Kim YR, Rhee JH

  • KMID: 1574182
  • J Bacteriol Virol.
  • 2005 Dec;35(4):299-306.
Recently we have shown that a bacterial flagellin, Vibrio vulnifiucs FlaB (Vv-FlaB), has a strong adjuvant activity to induce protective immune response. In order to investigate the adjuvanticity of Vv-FlaB,...
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