- Adverse effects of farnesyltransferase inhibitors on insulin actions
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Yi SJ, Jhun BH, Kim K
- KMID: 2394597
- J Biomed Transl Res.
- 2017 Sep;18(3):113-117.
- doi: 10.12729/jbtr.2017.18.3.113
Ras activates a series of downstream effectors, including the mitogen-activated protein kinase pathway and the Rac/Rho pathway after insulin stimulation. Mutations in Ras are found in approximately 30% of all... -
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- Effect of Extracellular Signal-Regulated Kinase Inhibition on Oxysterol 7-Ketocholesterol-Induced Apoptosis
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Hwang JY, Lee SW, Han JH, Kim DE, Lee CS
- KMID: 1966474
- J Korean Neurol Assoc.
- 2011 Nov;29(4):317-325.
BACKGROUND: Defects in mitochondrial function have been shown to participate in the induction of neuronal cell injury. The extracellular-signal-regulated kinase (ERK) signaling pathway plays a crucial role in almost all... -
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- Effect of Farnesyltransferase Inhibitor R115777 on Mitochondria of Plasmodium falciparum
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Ha YR, Hwang BG, Hong Y, Yang HW, Lee SJ
- KMID: 2381759
- Korean J Parasitol.
- 2015 Aug;53(4):421-430.
- doi: 10.3347/kjp.2015.53.4.421
The parasite Plasmodium falciparum causes severe malaria and is the most dangerous to humans. However, it exhibits resistance to their drugs. Farnesyltransferase has been identified in pathogenic protozoa of the... -
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- Genetic Polymorphism of Geranylgeranyl Diphosphate Synthase (GGSP1) Predicts Bone Density Response to Bisphosphonate Therapy in Korean Women
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Choi HJ, Choi JY, Cho SW, Kang D, Han KO, Kim SW, Kim SY, Chung YS, Shin CS
- KMID: 1126023
- Yonsei Med J.
- 2010 Mar;51(2):231-238.
- doi: 10.3349/ymj.2010.51.2.231
PURPOSE: Genetic factor is an important predisposing element influencing the susceptibility to osteoporosis and related complications. The purpose of the present study is to investigate whether genetic polymorphisms of farnesyl... -
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