- Synthesis of recombinant blood coagulation factor VIII (FVIII) heavy and light chains and reconstitution of active form of FVIII
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Oh SH, Lee MY, Song DW
- KMID: 1029938
- Exp Mol Med.
- 1999 Jun;31(2):95-100.
FVIII is synthesized as a single chain precursor of approximately 280 kD with the domain structure of A1-A2-B-A3-C1-C2 and it circulates as a series of metal ion-linked heterodimers that result from cleavages... -
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- T-CAM, a fastatin-FIII 9-10 fusion protein, potently enhances anti-angiogenic and anti-tumor activity via alphavbeta3 and alpha5beta1 integrins
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Nam JO, Jung MY, Thapa N, Lee BH, Park RW, Kim IS
- KMID: 1052942
- Exp Mol Med.
- 2008 Apr;40(2):196-207.
- doi: 10.3858/emm.2008.40.2.196
We made fusion protein of fastatin and FIII 9-10, termed tetra-cell adhesion molecule (T-CAM) that can interact simultaneously with alphavbeta3 and alpha5beta1 integrins, both playing important roles in tumor angiogenesis.... -
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