- A Glimpse into the Genome-wide DNA Methylation Changes in 6-hydroxydopamine-induced In Vitro Model of Parkinson’s Disease
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Magalingam KB, Somanath SD, Radhakrishnan AK
- KMID: 2544624
- Exp Neurobiol.
- 2023 Jun;32(3):119-132.
- doi: 10.5607/en22035
A cell-based model of Parkinson’s disease (PD) is a well-established in vitro experimental prototype to investigate the disease mechanism and therapeutic approach for a potential anti-PD drug. The SH-SY5Y human... -
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- An Automated Cell Detection Method for TH-positive Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease Using Convolutional Neural Networks
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Kim D, Bak MS, Park H, Baek IS, Chung G, Park JH, Ahn S, Park SY, Bae H, Park HJ, Kim SK
- KMID: 2544633
- Exp Neurobiol.
- 2023 Jun;32(3):181-194.
- doi: 10.5607/en23001
Quantification of tyrosine hydroxylase (TH)-positive neurons is essential for the preclinical study of Parkinson’s disease (PD). However, manual analysis of immunohistochemical (IHC) images is labor-intensive and has less reproducibility due... -
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- Monitoring α-synuclein Aggregation Induced by Preformed α-synuclein Fibrils in an In Vitro Model System
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Kim BJ, Noh HR, Jeon H, Park SM
- KMID: 2544626
- Exp Neurobiol.
- 2023 Jun;32(3):147-156.
- doi: 10.5607/en23007
Parkinson’s disease (PD) is characterized by the presence of α-synuclein (α-syn) inclusions in the brain and the degeneration of dopamine-producing neurons. There is evidence to suggest that the progression of... -
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- Modeling Long-term Spike Frequency Adaptation in SA-I Afferent Neurons Using an Izhikevich-based Biological Neuron Model
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Kim J, Choi YI, Sohn Jw, Kim SP, Jung SJ
- KMID: 2544627
- Exp Neurobiol.
- 2023 Jun;32(3):157-169.
- doi: 10.5607/en23005
To develop a biomimetic artificial tactile sensing system capable of detecting sustained mechanical touch, we propose a novel biological neuron model (BNM) for slowly adapting type I (SA-I) afferent neurons.... -
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- Intracellular Loop in the Brain Isoforms of Anoctamin 2 Channels Regulates Calcium-dependent Activation
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Lee D, Lim H, Lee J, Ha GE, No KT, Cheong E
- KMID: 2544625
- Exp Neurobiol.
- 2023 Jun;32(3):133-146.
- doi: 10.5607/en22045
Anoctamin 2 (ANO2 or TMEM16B), a calcium-activated chloride channel (CaCC), performs diverse roles in neurons throughout the central nervous system. In hippocampal neurons, ANO2 narrows action potential width and reduces... -
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- Machine Learning-assisted Quantitative Mapping of Intracortical Axonal Plasticity Following a Focal Cortical Stroke in Rodents
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Kim HS, Seo HG, Jhee JH, Park CH, Lee HW, Park B, Kim BG
- KMID: 2544628
- Exp Neurobiol.
- 2023 Jun;32(3):170-180.
- doi: 10.5607/en23016
Stroke destroys neurons and their connections leading to focal neurological deficits. Although limited, many patients exhibit a certain degree of spontaneous functional recovery. Structural remodeling of the intracortical axonal connections... -
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