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BMD42-2910, a Novel Benzoxazole Derivative, Shows a Potent Anti-prion Activity and Prolongs the Mean Survival in an Animal Model of Prion Disease

Hyeon JW, Noh R, Choi J, Lee SM, Lee YS, An SSA, No KT, Lee J

Prion diseases are a group of neurodegenerative and fatal central nervous system disorders. The pathogenic mechanism involves the conversion of cellular prion protein (PrPC) to an altered scrapie isoform (PrPSc),...
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Enhanced Bidirectional Connectivity of the Subthalamo-pallidal Pathway in 6-OHDA-mouse Model of Parkinson's Disease Revealed by Probabilistic Tractography of Diffusion-weighted MRI at 9.4T

Kim AY, Oh C, Im HJ, Baek HM

An important challenge in Parkinson’s disease (PD) based neuroscience and neuroimaging is mapping the neuronal connectivity of the basal ganglia to understand how the disease affects brain circuitry. However, a...
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Expression of Cellular Receptors in the Ischemic Hemisphere of Mice with Increased Glucose Uptake

Lee JS, Hong JM, Yoon BS, Son KS, Lee KE, Im DS, Park BN, An YS, Hwang DH, Park CB, Kim BG, Joe Eh

Many previous studies have shown reduced glucose uptake in the ischemic brain. In contrast, in a permanent unilateral common carotid artery occlusion (UCCAO) mouse model, our pilot experiments using 18F-fluorodeoxyglucose...
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Spatiotemporal Profile and Morphological Changes of NG2 Glia in the CA1 Region of the Rat Hippocampus after Transient Forebrain Ischemia

Jin X, Riew TR, Kim S, Kim HL, Lee MY

Neuron-glial antigen-2 (NG2) glia undergo proliferation and morphological changes following brain insults. Here, we show that NG2 glia is activated in a characteristic time- and layer-specific manner in the ischemia-vulnerable...
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New Features of Receptive Fields in Mouse Retina through Spike-triggered Covariance

Ahn J, Rueckauer , Yoo Y, Goo YS

Retinal ganglion cells (RGCs) encode various spatiotemporal features of visual information into spiking patterns. The receptive field (RF) of each RGC is usually calculated by spike-triggered average (STA), which is...
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Attentional Connectivity-based Prediction of Autism Using Heterogeneous rs-fMRI Data from CC200 Atlas

Liu Y, Xu L, Li J, Yu J, Yu X

Autism spectrum disorder (ASD) is a developmental syndrome characterized by obvious drawbacks in sociality and communication. It has crucial significance to exactly discern the individuals with ASD and typical controls...
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Distribution of Cadherin in the Parahippocampal Area of Developing Domestic Chicken Embryos

Zhou H, Wang X, Lin J, Zhao Z, Chang C

Hippocampal formation is important in spatial learning and memory. Members of the cadherin superfamily are observed in the neural system with diverse spatial and temporal expression patterns and are involved...
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From Bound Cells Comes a Sound Mind: The Role of Neuronal Growth Regulator 1 in Psychiatric Disorders

Noh K, Park JC, Han JS, Lee SJ

Cell-to-cell adhesion is important for maintenance of brain structure and function. Abnormal neuronal cell adhesion and loss of its connectivity are considered a main cause of psychiatric disorders such as...
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