- Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis
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Kang SJ, Kim JS, Park SM
- KMID: 2424732
- Exp Neurobiol.
- 2018 Oct;27(5):377-386.
- doi: 10.5607/en.2018.27.5.377
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neurons, and gathering evidence indicates that UCH-L1 may play pathogenic roles in many neurodegenerative disorders such... -
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- Circadian Regulation by REV-ERBα Mediates Hippocampal E-LTP in a Time-dependent Manner
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Choi JE, Kim S, Lee J, Kim K, Kaang BK
- KMID: 2424729
- Exp Neurobiol.
- 2018 Oct;27(5):344-349.
- doi: 10.5607/en.2018.27.5.344
Circadian rhythms are driven by circadian oscillators, and these rhythms result in the biological phenomenon of 24-h oscillations. Previous studies suggest that learning and memory are affected by circadian rhythms.... -
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- Differential Expression of Ca²âº-buffering Protein Calretinin in Cochlear Afferent Fibers: A Possible Link to Vulnerability to Traumatic Noise
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Sharma K, Seo YW, Yi E
- KMID: 2424734
- Exp Neurobiol.
- 2018 Oct;27(5):397-407.
- doi: 10.5607/en.2018.27.5.397
The synaptic contacts of cochlear afferent fibers (CAFs) with inner hair cells (IHCs) are spatially segregated according to their firing properties. CAFs also exhibit spatially segregated vulnerabilities to noise. The... -
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- HDAC3 Inhibition Promotes Alternative Activation of Macrophages but Does Not Affect Functional Recovery after Spinal Cord Injury
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Sanchez S, Lemmens S, Baeten P, Sommer D, Dooley D, Hendrix S, Gou Fabregas M
- KMID: 2424737
- Exp Neurobiol.
- 2018 Oct;27(5):437-452.
- doi: 10.5607/en.2018.27.5.437
After spinal cord injury (SCI), monocyte derived macrophages play a detrimental role. Histone deacetylases (HDACs) are central epigenetic regulators of macrophage-polarization. We hypothesized that HDAC3 inhibition suppresses the pro-inflammatory macrophage... -
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- Sex-specific Behavioral Features of Rodent Models of Autism Spectrum Disorder
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Jeon SJ, Gonzales E, Mabunga DF, Valencia S, Kim DG, Kim Y, Adil KJ, Shin D, Park D, Shin CY
- KMID: 2424728
- Exp Neurobiol.
- 2018 Oct;27(5):321-343.
- doi: 10.5607/en.2018.27.5.321
Sex is an important factor in understanding the clinical presentation, management, and developmental trajectory of children with neuropsychiatric disorders. While much is known about the clinical and neurobehavioral profiles of... -
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- A Group of Descending Glutamatergic Neurons Activated by Stress in Corticolimbic Regions Project to the Nucleus Accumbens
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Park JY, Park SY, Kwon H, Song Y, Yun B, Lee Y, Cho Y, Joo A, Han PL
- KMID: 2424733
- Exp Neurobiol.
- 2018 Oct;27(5):387-396.
- doi: 10.5607/en.2018.27.5.387
The nucleus accumbens (NAc) is the major component of the ventral striatum that regulates stress-induced depression. The NAc receives dopaminergic inputs from the ventral tegmental area (VTA), and the role... -
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- Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a G(αs) Protein-coupled Receptor
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Lee N, Sa M, Hong YR, Lee CJ, Koo J
- KMID: 2424731
- Exp Neurobiol.
- 2018 Oct;27(5):365-376.
- doi: 10.5607/en.2018.27.5.365
Medium-chain fatty acids (MCFAs) are mostly generated from dietary triglycerides and can penetrate the blood-brain barrier. Astrocytes in the brain use MCFAs as an alternative energy source. In addition, MCFAs... -
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- iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia
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Li L, Roh JH, Chang EH, Lee Y, Lee S, Kim M, Koh W, Chang JW, Kim HJ, Nakanishi , Barker RA, Na DL, Song J
- KMID: 2424730
- Exp Neurobiol.
- 2018 Oct;27(5):350-364.
- doi: 10.5607/en.2018.27.5.350
Disease modeling of Alzheimer's disease (AD) has been hampered by the lack of suitable cellular models while animal models are mainly based on the overexpression of AD-related genes which often... -
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- The Novel Neuroprotective Compound KMS99220 Has an Early Anti-neuroinflammatory Effect via AMPK and HO-1, Independent of Nrf2
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Lee JA, Kim HR, Kim J, Park KD, Kim DJ, Hwang O
- KMID: 2424735
- Exp Neurobiol.
- 2018 Oct;27(5):408-418.
- doi: 10.5607/en.2018.27.5.408
We have previously reported a novel synthetic compound KMS99220 that prevented degeneration of the nigral dopaminergic neurons and the associated motor deficits, suggesting a neuroprotective therapeutic utility for Parkinson's disease.... -
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- Chronic Treatment with Combined Chemotherapeutic Agents Affects Hippocampal Micromorphometry and Function in Mice, Independently of Neuroinflammation
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Kang S, Lee S, Kim J, Kim JC, Kim SH, Son Y, Shin T, Youn B, Kim JS, Wang H, Yang M, Moon C
- KMID: 2424736
- Exp Neurobiol.
- 2018 Oct;27(5):419-436.
- doi: 10.5607/en.2018.27.5.419
Chemotherapeutic agents induce long-term side effects, including cognitive impairment and mood disorders, particularly in breast cancer survivors who have undergone chemotherapy. However, the precise mechanisms underpinning chemotherapy-induced hippocampal dysfunction remain... -
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