- Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters
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Bang J, Kim HY, Lee H
- KMID: 2354874
- Exp Neurobiol.
- 2016 Oct;25(5):205-221.
- doi: 10.5607/en.2016.25.5.205
The brain consists of heterogeneous populations of neuronal and non-neuronal cells. The revelation of their connections and interactions is fundamental to understanding normal brain functions as well as abnormal changes... -
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- Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes
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Lee JW, Nam H, Yu SW
- KMID: 2354879
- Exp Neurobiol.
- 2016 Oct;25(5):262-268.
- doi: 10.5607/en.2016.25.5.262
Translocator protein 18 kDa (TSPO) is a mitochondrial protein highly expressed on reactive microglia and astrocytes, and is considered as a biomarker for neurodegeneration and brain damage, especially neuroinflammation. Toll-like... -
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- Optogenetic Glia Manipulation: Possibilities and Future Prospects
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Cho WH, Barcelon E, Lee SJ
- KMID: 2354873
- Exp Neurobiol.
- 2016 Oct;25(5):197-204.
- doi: 10.5607/en.2016.25.5.197
Our brains are composed of two distinct cell types: neurons and glia. Emerging data from recent investigations show that glial cells, especially astrocytes and microglia, are able to regulate synaptic... -
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- Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS
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Lee J, Hyeon SJ, Im H, Ryu H, Kim Y, Ryu H
- KMID: 2354876
- Exp Neurobiol.
- 2016 Oct;25(5):233-240.
- doi: 10.5607/en.2016.25.5.233
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that leads to a progressive muscle wasting and paralysis. The pathological phenotypes are featured by severe motor neuron death and glial... -
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- Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells
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Kim JY, Park J, Chang JY, Kim SH, Lee JE
- KMID: 2354877
- Exp Neurobiol.
- 2016 Oct;25(5):241-251.
- doi: 10.5607/en.2016.25.5.241
The immune response after stroke is known to play a major role in ischemic brain pathobiology. The inflammatory signals released by immune mediators activated by brain injury sets off a... -
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- Two-pore Domain Potassium Channels in Astrocytes
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Ryoo K, Park JY
- KMID: 2354875
- Exp Neurobiol.
- 2016 Oct;25(5):222-232.
- doi: 10.5607/en.2016.25.5.222
Two-pore domain potassium (K(2P)) channels have a distinct structure and channel properties, and are involved in a background K⺠current. The 15 members of the K(2P) channels are identified and... -
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- Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation
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Song GJ, Kim J, Kim JH, Song S, Park H, Zhang ZY, Suk K
- KMID: 2354878
- Exp Neurobiol.
- 2016 Oct;25(5):252-261.
- doi: 10.5607/en.2016.25.5.252
Protein tyrosine phosphatases (PTPs) are key regulatory factors in inflammatory signaling pathways. Although PTPs have been extensively studied, little is known about their role in neuroinflammation. In the present study,... -
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- LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2
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Choi I, Byun JW, Park SM, Jou I, Joe EH
- KMID: 2354880
- Exp Neurobiol.
- 2016 Oct;25(5):269-276.
- doi: 10.5607/en.2016.25.5.269
Mutation of leucine-rich repeat kinase 2 (LRRK2) causes an autosomal dominant and late-onset familial Parkinson's disease (PD). Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474... -
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