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Rapid Progression of Sporadic ALS in a Patient Carrying SOD1 p.Gly13Arg Mutation

Kim MJ, Bae JH, Kim JM, Kim HR, Yoon BN, Sung JJ, Ahn SW

Amyotrophic lateral sclerosis (ALS), the most common adult onset motor neuron disease, is pathologically characterized by progressive loss of the upper and lower motor neurons. Mutations in the Cu/Zn superoxide...
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Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice

Lee J, Ko HG, Kim K, Kaang BK

Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in...
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Prefrontal Cortical Thickness Deficit in Detoxified Alcohol-dependent Patients

Bae S, Kang I, Lee BC, Jeon Y, Cho HB, Yoon S, Lim SM, Kim J, Lyoo IK, Kim JE, Choi IG

Alcohol dependence is a serious disorder that can be related with a number of potential health-related and social consequences. Cortical thickness measurements would provide important information on the cortical structural...
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Neonatal Administration of Memantine Enhances Social Cognition in Adult Rats Subjected to Early Maternal Deprivation

Uribe E, Sánchez-Mendoza E, Nieves N, Merchor G

Schizophrenia is considered a neurodevelopmental disorder; however, all the available treatment options are used when the disease becomes clinically significant in adolescence or early adulthood. Using a developmental rat model...
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Chronic Nonmodulated Microwave Radiations in Mice Produce Anxiety-like and Depression-like Behaviours and Calcium- and NO-related Biochemical Changes in the Brain

Kumar M, Singh SP, Chaturvedi CM

The present study was aimed to investigate behavioural and biochemical effects of chronic exposure of amplitude modulated and non-modulated microwave radiation on laboratory mice. Chronic microwave exposures were executed with...
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Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors

Kim TK, Han PL

Chronic stress induces changes in neuronal functions in specific brain regions regulating sociability and mood-related behaviors. Recently we reported that stress-induced persistent upregulation of the neuropeptides orexin and melanin-concentrating hormone...
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Bipolar Disorder Associated microRNA, miR-1908-5p, Regulates the Expression of Genes Functioning in Neuronal Glutamatergic Synapses

Kim Y, Zhang Y, Pang K, Kang H, Park H, Lee Y, Lee B, Lee HJ, Kim WK, Geum D, Han K

Bipolar disorder (BD), characterized by recurrent mood swings between depression and mania, is a highly heritable and devastating mental illness with poorly defined pathophysiology. Recent genome-wide molecular genetic studies have...
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Molecular Neuroimaging in Posttraumatic Stress Disorder

Im JJ, Namgung E, Choi Y, Kim JY, Rhie SJ, Yoon S

Over the past decade, an increasing number of neuroimaging studies have provided insight into the neurobiological mechanisms of posttraumatic stress disorder (PSTD). In particular, molecular neuroimaging techniques have been employed...
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