- Multiple System Atrophy: Genetic or Epigenetic?
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Sturm E, Stefanova
- KMID: 2165534
- Exp Neurobiol.
- 2014 Dec;23(4):277-291.
- doi: 10.5607/en.2014.23.4.277
Multiple system atrophy (MSA) is a rare, late-onset and fatal neurodegenerative disease including multisystem neurodegeneration and the formation of alpha-synuclein containing oligodendroglial cytoplasmic inclusions (GCIs), which present the hallmark of... -
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- ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy
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Lopes da Fonseca T, Outeiro TF
- KMID: 2165536
- Exp Neurobiol.
- 2014 Dec;23(4):314-323.
- doi: 10.5607/en.2014.23.4.314
Parkinson's Disease (PD) is a complex and multifactorial disorder of both idiopathic and genetic origin. Thus far, more than 20 genes have been linked to familial forms of PD. Two... -
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- Involvement of Endoplasmic Reticulum Stress Response in Orofacial Inflammatory Pain
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Yang ES, Bae JY, Kim TH, Kim YS, Suk K, Bae YC
- KMID: 2165542
- Exp Neurobiol.
- 2014 Dec;23(4):372-380.
- doi: 10.5607/en.2014.23.4.372
Endoplasmic reticulum (ER) stress is involved in many neurological diseases and inflammatory responses. Inflammatory mediators induce neuronal damage and trigger the neuropathic or inflammatory pain. But there is very little... -
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- Alpha-Synuclein Function and Dysfunction on Cellular Membranes
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Snead D, Eliezer D
- KMID: 2165535
- Exp Neurobiol.
- 2014 Dec;23(4):292-313.
- doi: 10.5607/en.2014.23.4.292
Alpha-synuclein is a small neuronal protein that is closely associated with the etiology of Parkinson's disease. Mutations in and alterations in expression levels of alpha-synuclein cause autosomal dominant early onset... -
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- Protein Transmission, Seeding and Degradation: Key Steps for alpha-Synuclein Prion-Like Propagation
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Oueslati A, Ximerakis , Vekrellis
- KMID: 2165537
- Exp Neurobiol.
- 2014 Dec;23(4):324-336.
- doi: 10.5607/en.2014.23.4.324
Converging lines of evidence suggest that cell-to-cell transmission and the self-propagation of pathogenic amyloidogenic proteins play a central role in the initiation and the progression of several neurodegenerative disorders. This... -
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- Hypothesis: Somatic Mosaicism and Parkinson Disease
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Kim HJ, Jeon BS
- KMID: 2165533
- Exp Neurobiol.
- 2014 Dec;23(4):271-276.
- doi: 10.5607/en.2014.23.4.271
Mutations causing genetic disorders can occur during mitotic cell division after fertilization, which is called somatic mutations. This leads to somatic mosaicism, where two or more genetically distinct cells are... -
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- Mitochondrial Homeostasis Molecules: Regulation by a Trio of Recessive Parkinson's Disease Genes
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Han JY, Kim JS, Son JH
- KMID: 2165539
- Exp Neurobiol.
- 2014 Dec;23(4):345-351.
- doi: 10.5607/en.2014.23.4.345
Mitochondria are small organelles that produce the majority of cellular energy as ATP. Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), and rare familial forms of... -
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- ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter alpha-Synuclein Metabolism in SH-SY5Y Cells
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Bae EJ, Lee C, Lee HJ, Kim S, Lee SJ
- KMID: 2165541
- Exp Neurobiol.
- 2014 Dec;23(4):365-371.
- doi: 10.5607/en.2014.23.4.365
Parkinson's disease is a multifactorial disorder with several genes linked to the familial types of the disease. ATP13A2 is one of those genes and encode for a transmembrane protein localized... -
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- Exploring Myelin Dysfunction in Multiple System Atrophy
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Wong JH, Halliday G, Kim WS
- KMID: 2165538
- Exp Neurobiol.
- 2014 Dec;23(4):337-344.
- doi: 10.5607/en.2014.23.4.337
Multiple system atrophy (MSA) is a rare, yet fatal neurodegenerative disease that presents clinically with autonomic failure in combination with parkinsonism or cerebellar ataxia. MSA impacts on the autonomic nervous... -
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- What is the Clinical Significance of Cerebrospinal Fluid Biomarkers in Parkinson's disease? Is the Significance Diagnostic or Prognostic?
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Kim D, Paik JH, Shin DW, Kim HS, Park CS, Kang JH
- KMID: 2165540
- Exp Neurobiol.
- 2014 Dec;23(4):352-364.
- doi: 10.5607/en.2014.23.4.352
The clinical diagnostic criteria of Parkinson's disease (PD) have limitations in detecting the disease at early stage and in differentiating heterogeneous clinical progression. The lack of reliable biomarker(s) for early... -
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