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Involvement of Endoplasmic Reticulum Stress Response in Orofacial Inflammatory Pain

Yang ES, Bae JY, Kim TH, Kim YS, Suk K, Bae YC

Endoplasmic reticulum (ER) stress is involved in many neurological diseases and inflammatory responses. Inflammatory mediators induce neuronal damage and trigger the neuropathic or inflammatory pain. But there is very little...
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ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter alpha-Synuclein Metabolism in SH-SY5Y Cells

Bae EJ, Lee C, Lee HJ, Kim S, Lee SJ

Parkinson's disease is a multifactorial disorder with several genes linked to the familial types of the disease. ATP13A2 is one of those genes and encode for a transmembrane protein localized...
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What is the Clinical Significance of Cerebrospinal Fluid Biomarkers in Parkinson's disease? Is the Significance Diagnostic or Prognostic?

Kim D, Paik JH, Shin DW, Kim HS, Park CS, Kang JH

The clinical diagnostic criteria of Parkinson's disease (PD) have limitations in detecting the disease at early stage and in differentiating heterogeneous clinical progression. The lack of reliable biomarker(s) for early...
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Mitochondrial Homeostasis Molecules: Regulation by a Trio of Recessive Parkinson's Disease Genes

Han JY, Kim JS, Son JH

Mitochondria are small organelles that produce the majority of cellular energy as ATP. Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), and rare familial forms of...
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Exploring Myelin Dysfunction in Multiple System Atrophy

Wong JH, Halliday G, Kim WS

Multiple system atrophy (MSA) is a rare, yet fatal neurodegenerative disease that presents clinically with autonomic failure in combination with parkinsonism or cerebellar ataxia. MSA impacts on the autonomic nervous...
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Protein Transmission, Seeding and Degradation: Key Steps for alpha-Synuclein Prion-Like Propagation

Oueslati A, Ximerakis , Vekrellis

Converging lines of evidence suggest that cell-to-cell transmission and the self-propagation of pathogenic amyloidogenic proteins play a central role in the initiation and the progression of several neurodegenerative disorders. This...
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ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy

Lopes da Fonseca T, Outeiro TF

Parkinson's Disease (PD) is a complex and multifactorial disorder of both idiopathic and genetic origin. Thus far, more than 20 genes have been linked to familial forms of PD. Two...
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Alpha-Synuclein Function and Dysfunction on Cellular Membranes

Snead D, Eliezer D

Alpha-synuclein is a small neuronal protein that is closely associated with the etiology of Parkinson's disease. Mutations in and alterations in expression levels of alpha-synuclein cause autosomal dominant early onset...
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Multiple System Atrophy: Genetic or Epigenetic?

Sturm E, Stefanova

Multiple system atrophy (MSA) is a rare, late-onset and fatal neurodegenerative disease including multisystem neurodegeneration and the formation of alpha-synuclein containing oligodendroglial cytoplasmic inclusions (GCIs), which present the hallmark of...
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Hypothesis: Somatic Mosaicism and Parkinson Disease

Kim HJ, Jeon BS

Mutations causing genetic disorders can occur during mitotic cell division after fertilization, which is called somatic mutations. This leads to somatic mosaicism, where two or more genetically distinct cells are...
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