- Deciphering cellular and molecular causes of the tumor functional heterogeneity of liver cancer
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Nam SW
- KMID: 2438345
- Exp Mol Med.
- 2018 Jan;50(1):e415.
- doi: 10.1038/emm.2017.188
No abstract available. -
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- The significance of intertumor and intratumor heterogeneity in liver cancer
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Liu J, Dang H, Wang XW
- KMID: 2438346
- Exp Mol Med.
- 2018 Jan;50(1):e416.
- doi: 10.1038/emm.2017.165
Genomic analyses of primary liver cancer samples reveal a complex mutational landscape with vast intertumor and intratumor heterogeneity. Different primary liver tumors and subclones within each tumor display striking molecular... -
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- In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment
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Hirschfield H, Bian CB, Higashi T, Nakagawa S, Zeleke TZ, Nair VD, Fuchs BC, Hoshida Y
- KMID: 2438349
- Exp Mol Med.
- 2018 Jan;50(1):e419.
- doi: 10.1038/emm.2017.164
Tractable experimental model that accounts for inter-tumor molecular heterogeneity is a key element of anti-cancer drug development. Hepatocellular carcinoma is known to exhibit highly heterogeneous molecular aberrations across the tumors,... -
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- Glutamine synthetase mediates sorafenib sensitivity in β-catenin-active hepatocellular carcinoma cells
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Sohn BH, Park IY, Shin JH, Yim SY, Lee JS
- KMID: 2438351
- Exp Mol Med.
- 2018 Jan;50(1):e421.
- doi: 10.1038/emm.2017.174
The gene encoding β-catenin is frequently mutated in hepatocellular carcinoma cells. While the oncogenicity of β-catenin has been extensively studied, β-catenin’s role in hepatocellular carcinoma tumor metabolism is currently less... -
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- Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation
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Kim EK, Lee SH, Lee SY, Kim JK, Jhun JY, Na HS, Kim SY, Choi JY, Yang CW, Park SH, Cho ML
- KMID: 2438362
- Exp Mol Med.
- 2018 Jan;50(1):e432.
- doi: 10.1038/emm.2017.245
Rheumatoid arthritis (RA) is a systemic autoimmune disease involving excessive inflammation. Recently, RA associated with a metabolic disorder was revealed to be non-responsive to RA medications. Metformin has been reported... -
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- PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis
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Yang X, Fu Y, Hu F, Luo X, Hu J, Wang G
- KMID: 2438361
- Exp Mol Med.
- 2018 Jan;50(1):e431.
- doi: 10.1038/emm.2017.243
Phosphatidylinositol 3-kinase (PI3K) signaling plays an important role in the regulation of cellular lipid metabolism and non-alcoholic fatty liver disease (NAFLD). However, little is known about the role of the... -
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- Critical effects of long non-coding RNA on fibrosis diseases
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Zhang Y, Luo G, Zhang Y, Zhang M, Zhou J, Gao W, Xuan X, Yang X, Yang D, Tian Z, Ni B, Tang J
- KMID: 2438358
- Exp Mol Med.
- 2018 Jan;50(1):e428.
- doi: 10.1038/emm.2017.223
The expression or dysfunction of long non-coding RNAs (lncRNAs) is closely related to various hereditary diseases, autoimmune diseases, metabolic diseases and tumors. LncRNAs were also recently recognized as functional regulators... -
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- Depletion of S100A4⺠stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors
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Jiao J, González , Stevenson , Gagea M, Sugimoto H, Kalluri R, Beretta L
- KMID: 2438352
- Exp Mol Med.
- 2018 Jan;50(1):e422.
- doi: 10.1038/emm.2017.175
There is a pressing need for the development of novel approaches to treat and prevent hepatocellular carcinoma (HCC). The S100 calcium-binding protein S100A4 is associated with poor prognosis and metastasis... -
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- Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota
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Xiao HW, Li Y, Luo D, Dong JL, Zhou LX, Zhao SY, Zheng QS, Wang HC, Cui M, Fan SJ
- KMID: 2438363
- Exp Mol Med.
- 2018 Jan;50(1):e433.
- doi: 10.1038/emm.2017.246
Although radiation therapy is a cornerstone of modern management of malignancies, various side effects are inevitably linked to abdominal and pelvic cancer after radiotherapy. Radiation-mediated gastrointestinal (GI) toxicity impairs the... -
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- Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target
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Tsai MS, Lee PH, Sun CK, Chiu TC, Lin YC, Chang IW, Chen PH, Kao YH
- KMID: 2438356
- Exp Mol Med.
- 2018 Jan;50(1):e426.
- doi: 10.1038/emm.2017.235
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in... -
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- Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway
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Xu Z, Hu J, Cao H, Pilo MG, Cigliano A, Shao Z, Xu M, Ribback S, Dombrowski F, Calvisi DF, Chen X
- KMID: 2438347
- Exp Mol Med.
- 2018 Jan;50(1):e417.
- doi: 10.1038/emm.2017.158
Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options. Activation of the AKT/mTOR cascade is one of the most frequent events along hepatocarcinogenesis. mTOR is a serine/threonine kinase... -
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- A gene expression signature of FOXM1 predicts the prognosis of hepatocellular carcinoma
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Song BN, Chu IS
- KMID: 2438348
- Exp Mol Med.
- 2018 Jan;50(1):e418.
- doi: 10.1038/emm.2017.159
FOXM1 (Forkhead box M1) is a key regulator of tumorigenesis. Previous studies demonstrated that FOXM1 overexpression was strongly correlated with poor prognosis in various cancers, including hepatocellular carcinoma (HCC). In... -
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- RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis
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Kim W, Youn H, Lee S, Kim E, Kim D, Sub Lee J, Lee JM, Youn B
- KMID: 2438364
- Exp Mol Med.
- 2018 Jan;50(1):e434.
- doi: 10.1038/emm.2017.247
An interaction between ribosomal protein S3 (rpS3) and nuclear factor kappa B or macrophage migration inhibitory factor in non-small-cell lung cancer is responsible for radioresistance. However, the role of rpS3... -
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- Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration
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Lu L, Finegold M, Johnson RL
- KMID: 2438353
- Exp Mol Med.
- 2018 Jan;50(1):e423.
- doi: 10.1038/emm.2017.205
The mammalian liver has a remarkable capacity for repair following injury. Removal of up to two-third of liver mass results in a series of events that include extracellular matrix remodeling,... -
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- Effects of microRNA-135a on the epithelial–mesenchymal transition, migration and invasion of bladder cancer cells by targeting GSK3β through the Wnt/β-catenin signaling pathway
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Mao XW, Xiao JQ, Li ZY, Zheng YC, Zhang N
- KMID: 2438359
- Exp Mol Med.
- 2018 Jan;50(1):e429.
- doi: 10.1038/emm.2017.239
This study investigated the effects of microRNA-135a (miR-135a) targeting of glycogen synthase kinase 3β (GSK3β) on the epithelial–mesenchymal transition (EMT), migration and invasion of bladder cancer (BC) cells by mediating... -
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- Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin
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Jeong BY, Cho KH, Jeong KJ, Park YY, Kim JM, Rha SY, Park CG, Mills GB, Cheong JH, Lee HY
- KMID: 2438365
- Exp Mol Med.
- 2018 Jan;50(1):e435.
- doi: 10.1038/emm.2017.248
The small GTP-binding protein Rab25 is associated with tumor formation and progression. However, recent studies have shown discordant effects of Rab25 on cancer cell progression depending on cell lineage. In... -
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- Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration
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Jeong SJ, Kim JH, Lim BJ, Yoon I, Song JA, Moon HS, Kim D, Lee DK, Kim S
- KMID: 2438354
- Exp Mol Med.
- 2018 Jan;50(1):e424.
- doi: 10.1038/emm.2017.231
Mucin1 (MUC1), a heterodimeric oncoprotein, containing tandem repeat structures with a high proportion of threonine, is aberrantly overexpressed in many human cancers including pancreatic cancer. Since the overall survival rate... -
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- Immunomodulatory effect of CD200-positive human placenta-derived stem cells in the early phase of stroke
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Kong T, Park JM, Jang JH, Kim CY, Bae SH, Choi Y, Jeong YH, Kim C, Chang SW, Kim J, Moon J
- KMID: 2438355
- Exp Mol Med.
- 2018 Jan;50(1):e425.
- doi: 10.1038/emm.2017.233
Human placenta amniotic membrane-derived mesenchymal stem cells (AMSCs) regulate immune responses, and this property can be exploited to treat stroke patients via cell therapy. We investigated the expression profile of... -
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- T-cell immune regulator 1 enhances metastasis in hepatocellular carcinoma
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Yang HD, Eun JW, Lee KB, Shen Q, Kim HS, Kim SY, Seo DW, Park WS, Lee JY, Nam SW
- KMID: 2438350
- Exp Mol Med.
- 2018 Jan;50(1):e420.
- doi: 10.1038/emm.2017.166
Recurrence and metastasis are major challenges in the management of hepatocellular carcinoma (HCC) patients after resection. To identify a metastasis-associated gene signature, we performed comparative gene expression analysis with recurrent... -
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- Proangiogenic functions of an RGD-SLAY-containing osteopontin icosamer peptide in HUVECs and in the postischemic brain
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Lee H, Jin YC, Kim SW, Kim ID, Lee HK, Lee JK
- KMID: 2438360
- Exp Mol Med.
- 2018 Jan;50(1):e430.
- doi: 10.1038/emm.2017.241
Osteopontin (OPN) is a phosphorylated glycoprotein secreted into body fluids by various cell types. OPN contains arginine-glycine-aspartate (RGD) and serine-leucine-alanine-tyrosine (SLAY) motifs that bind to several integrins and mediate a... -
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