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20(S)-Protopanaxadiol enhances angiogenesis via HIF-1α-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice

Zhang EY, Gao B, Shi HL, Huang LF, Yang L, Wu XJ, Wang ZT

Impaired angiogenesis is one of the crucial factors that impede the wound healing process in diabetic foot ulcers (DFUs). In this study, we found that 20(S)-protopanaxadiol (PPD), an aglycone of...
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miR-31a-5p promotes postnatal cardiomyocyte proliferation by targeting RhoBTB1

Xiao J, Liu H, Cretoiu D, Toader DO, Suciu N, Shi J, Shen S, Bei Y, Sluijter J, Das S, Kong X, Li X

A limited number of microRNAs (miRNAs, miRs) have been reported to control postnatal cardiomyocyte proliferation, but their strong regulatory effects suggest a possible therapeutic approach to stimulate regenerative capacity in...
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Ctbp2-mediated β-catenin regulation is required for exit from pluripotency

Kim TW, Kwak S, Shin J, Kang BH, Lee SE, Suh MY, Kim JH, Hwang IY, Lee JH, Choi J, Cho EJ, Youn HD

The canonical Wnt pathway is critical for embryonic stem cell (ESC) pluripotency and aberrant control of β-catenin leads to failure of exit from pluripotency and lineage commitments. Hence, maintaining the...
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Muscle fatigue: general understanding and treatment

Wan JJ, Qin Z, Wang PY, Sun Y, Liu X

Muscle fatigue is a common complaint in clinical practice. In humans, muscle fatigue can be defined as exercise-induced decrease in the ability to produce force. Here, to provide a general...
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