- Dysregulation of gut microbiota and chronic inflammatory disease: from epithelial defense to host immunity
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Koh JH, Kim WU
- KMID: 2382699
- Exp Mol Med.
- 2017 May;49(5):e337.
- doi: 10.1038/emm.2017.55
No abstract available. -
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- Engulfment signals and the phagocytic machinery for apoptotic cell clearance
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Park SY, Kim IS
- KMID: 2382693
- Exp Mol Med.
- 2017 May;49(5):e331.
- doi: 10.1038/emm.2017.52
The clearance of apoptotic cells is an essential process for tissue homeostasis. To this end, cells undergoing apoptosis must display engulfment signals, such as ‘find-me' and ‘eat-me' signals. Engulfment signals... -
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- The interplay between host immune cells and gut microbiota in chronic inflammatory diseases
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Kim D, Zeng MY, Núñez G
- KMID: 2382701
- Exp Mol Med.
- 2017 May;49(5):e339.
- doi: 10.1038/emm.2017.24
Many benefits provided by the gut microbiota to the host rely on its intricate interactions with host cells. Perturbations of the gut microbiota, termed gut dysbiosis, affect the interplay between... -
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- Roles of intestinal epithelial cells in the maintenance of gut homeostasis
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Okumura R, Takeda K
- KMID: 2382700
- Exp Mol Med.
- 2017 May;49(5):e338.
- doi: 10.1038/emm.2017.20
The intestine is a unique organ inhabited by a tremendous number of microorganisms. Intestinal epithelial cells greatly contribute to the maintenance of the symbiotic relationship between gut microbiota and the... -
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- Role of carbonic anhydrases in skin wound healing
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Barker H, Aaltonen M, Pan P, Vähätupa M, Kaipiainen P, May U, Prince S, Uusitalo-Järvinen H, Waheed A, Pastoreková S, Sly WS, Parkkila S, Järvinen
- KMID: 2382696
- Exp Mol Med.
- 2017 May;49(5):e334.
- doi: 10.1038/emm.2017.60
Skin wound closure occurs when keratinocytes migrate from the edge of the wound and re-epithelialize the epidermis. Their migration takes place primarily before any vascularization is established, that is, under... -
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- microRNA-200a-3p increases 5-fluorouracil resistance by regulating dual specificity phosphatase 6 expression
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Lee H, Kim C, Kang H, Tak H, Ahn S, Yoon SK, Kuh HJ, Kim W, Lee EK
- KMID: 2382689
- Exp Mol Med.
- 2017 May;49(5):e327.
- doi: 10.1038/emm.2017.33
Acquisition of resistance to anti-cancer drugs is a significant obstacle to effective cancer treatment. Although several efforts have been made to overcome drug resistance in cancer cells, the detailed mechanisms... -
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- Aberrant epigenetic regulation of GABRP associates with aggressive phenotype of ovarian cancer
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Sung HY, Yang SD, Ju W, Ahn JH
- KMID: 2382697
- Exp Mol Med.
- 2017 May;49(5):e335.
- doi: 10.1038/emm.2017.62
Metastasis is a major cause of therapeutic failure in ovarian cancer. To elucidate molecular mechanisms of ovarian cancer metastasis, we previously established a metastatic xenograft mouse model using human ovarian... -
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- Microbiota in T-cell homeostasis and inflammatory diseases
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Lee N, Kim WU
- KMID: 2382702
- Exp Mol Med.
- 2017 May;49(5):e340.
- doi: 10.1038/emm.2017.36
The etiology of disease pathogenesis can be largely explained by genetic variations and several types of environmental factors. In genetically disease-susceptible individuals, subsequent environmental triggers may induce disease development. The... -
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- Helicobacter pylori-derived extracellular vesicles increased in the gastric juices of gastric adenocarcinoma patients and induced inflammation mainly via specific targeting of gastric epithelial cells
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Choi HI, Choi JP, Seo J, Kim BJ, Rho M, Han JK, Kim JG
- KMID: 2382692
- Exp Mol Med.
- 2017 May;49(5):e330.
- doi: 10.1038/emm.2017.47
Evidence indicates that Helicobacter pylori is the causative agent of chronic gastritis and perhaps gastric malignancy. Extracellular vesicles (EVs) play an important role in the evolutional process of malignancy due... -
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- Upregulation and biological function of transmembrane protein 119 in osteosarcoma
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Jiang ZH, Peng J, Yang HL, Fu XL, Wang JZ, Liu L, Jiang JN, Tan YF, Ge ZJ
- KMID: 2382691
- Exp Mol Med.
- 2017 May;49(5):e329.
- doi: 10.1038/emm.2017.41
Osteosarcoma is suggested to be caused by genetic and molecular alterations that disrupt osteoblast differentiation. Recent studies have reported that transmembrane protein 119 (TMEM119) contributes to osteoblast differentiation and bone... -
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- Bone-forming peptide-2 derived from BMP-7 enhances osteoblast differentiation from multipotent bone marrow stromal cells and bone formation
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Kim HK, Lee JS, Kim JH, Seon JK, Park KS, Jeong MH, Yoon TR
- KMID: 2382690
- Exp Mol Med.
- 2017 May;49(5):e328.
- doi: 10.1038/emm.2017.40
Strategies for efficient osteogenic differentiation and bone formation from stem cells would have clinical applications in treating nonunion fracture healing. Many researchers have attempted to develop adjuvants as specific stimulators... -
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- Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy
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Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC
- KMID: 2382695
- Exp Mol Med.
- 2017 May;49(5):e333.
- doi: 10.1038/emm.2017.56
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder that is associated with repetitive head injury and has distinctive neuropathological features that differentiate this disease from other neurodegenerative diseases. Intraneuronal... -
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- A FKBP5 mutation is associated with Paget's disease of bone and enhances osteoclastogenesis
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Lu B, Jiao Y, Wang Y, Dong J, Wei M, Cui B, Sun Y, Wang L, Zhang B, Chen Z, Zhao Y
- KMID: 2382698
- Exp Mol Med.
- 2017 May;49(5):e336.
- doi: 10.1038/emm.2017.64
Paget's disease of bone (PDB) is a common metabolic bone disease that is characterized by aberrant focal bone remodeling, which is caused by excessive osteoclastic bone resorption followed by disorganized... -
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- Lentivirus-mediated microRNA-124 gene-modified bone marrow mesenchymal stem cell transplantation promotes the repair of spinal cord injury in rats
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Song JL, Zheng W, Chen W, Qian Y, Ouyang YM, Fan CY
- KMID: 2382694
- Exp Mol Med.
- 2017 May;49(5):e332.
- doi: 10.1038/emm.2017.48
Our study aims to explore the effects of lentivirus-mediated microRNA-124 (miR-124) gene-modified bone marrow mesenchymal stem cell (BMSC) transplantation on the repair of spinal cord injury (SCI) in rats. BMSCs... -
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