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Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis

Agrawal V, Kim DY, Kwon YG

Tumor growth is governed by the coordinated action of various types of cells that are present in the tumor environment. Fibroblasts, which constitute a major fraction of the stroma, participate...
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hMSCs suppress neutrophil-dominant airway inflammation in a murine model of asthma

Hong GH, Kwon HS, Lee KY, Ha EH, Moon KA, Kim SW, Oh W, Kim TB, Moon HB, Cho YS

Although chronic eosinophilic inflammation is a common feature in patients with asthma, some patients have neutrophil-dominant inflammation, which is known to be associated with severe asthma.Human mesenchymal stem cells (hMSCs)...
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Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro

Shin SK, Kim JH, Lee JH, Son YH, Lee MW, Kim HJ, Noh SA, Kim KP, Kim IG, Lee MJ

Proteasomes are the primary degradation machinery for oxidatively damaged proteins that compose a class of misfolded protein substrates. Cellular levels of reactive oxygen species increase with age and this cellular...
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Paclitaxel-resistant cancer cell-derived secretomes elicit ABCB1-associated docetaxel cross-resistance and escape from apoptosis through FOXO3a-driven glycolytic regulation

Aldonza MB, Hong JY, Lee SK

Chemotherapy-induced cancer cell secretomes promote resistance due, in part, to a predominant glycolytic energy metabolism, which drives aggressive cancer cell proliferation. However, the characterization of these secretomes and the molecular...
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Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy

Tomasetti , Lee W, Santarelli L, Neuzil J

Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell–cell communication by transferring nucleic acids and proteins...
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Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway

Kim YS, Kim JY, Cho R, Shin DM, Lee SW, Oh YM

Cell therapy using stem cells has produced therapeutic benefits in animal models of COPD. Secretory mediators are proposed as one mechanism for stem cell effects because very few stem cells...
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Gene-metabolite network analysis in different nonalcoholic fatty liver disease phenotypes

Liu XL, Ming YN, Zhang JY, Chen XY, Zeng MD, Mao YM

We sought to identify common key regulators and build a gene-metabolite network in different nonalcoholic fatty liver disease (NAFLD) phenotypes. We used a high-fat diet (HFD), a methionine-choline-deficient diet (MCDD)...
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Bioinformatic identification of prognostic signature defined by copy number alteration and expression of CCNE1 in non-muscle invasive bladder cancer

Song BN, Kim SK, Chu IS

Non-muscle invasive bladder cancer (NMIBC) patients frequently fail to respond to treatment and experience disease progression because of their clinical and biological diversity. In this study, we identify a prognostic...
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Epigenetic regulation and chromatin remodeling in learning and memory

Kim S, Kaang BK

Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in the field of neuroscience. Memory formation and maintenance are tightly controlled complex processes. Among the...
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