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Modulation of gene expression dynamics by co-transcriptional histone methylations

Woo H, Ha SD, Lee SB, Buratowski S, Kim T

Co-transcriptional methylations of histone H3 at lysines 4 and 36, highly conserved methyl marks from yeast to humans, have profound roles in regulation of histone acetylation. These modifications function to...
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Histone lysine demethylases in mammalian embryonic development

Shen H, Xu W, Lan F

Post-translational modifications, such as methylation, acetylation and phosphorylation, of histone proteins play important roles in regulating dynamic chromatin structure. Histone demethylation has become one of the most active research areas...
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Writing, erasing and reading histone lysine methylations

Hyun K, Jeon J, Park K, Kim J

Histone modifications are key epigenetic regulatory features that have important roles in many cellular events. Lysine methylations mark various sites on the tail and globular domains of histones and their...
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TET family dioxygenases and DNA demethylation in stem cells and cancers

An J, Rao A, Ko M

The methylation of cytosine and subsequent oxidation constitutes a fundamental epigenetic modification in mammalian genomes, and its abnormalities are intimately coupled to various pathogenic processes including cancer development. Enzymes of...
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DNA methylation: an epigenetic mark of cellular memory

Kim M, Costello J

DNA methylation is a stable epigenetic mark that can be inherited through multiple cell divisions. During development and cell differentiation, DNA methylation is dynamic, but some DNA methylation patterns may...
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Methylation and demethylation of DNA and histones in chromatin: the most complicated epigenetic marker

Youn HD

No abstract available.
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An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation

Ma YJ, Lee BL, Garred P

The complement system is an innate immune defense machinery comprising components that deploy rapid immune responses and provide efficient protection against foreign invaders and unwanted host elements. The complement system...
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Cyclophosphamide-induced HCN1 channel upregulation in interstitial Cajal-like cells leads to bladder hyperactivity in mice

Liu Q, Long Z, Dong X, Zhang T, Zhao J, Sun B, Zhu J, Li J, Wang Q, Yang Z, Hu X, Li L

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are confirmed to be expressed in bladder interstitial Cajal-like cells (ICC-LCs), but little is known about their possible role in cystitis-associated bladder dysfunction. The present...
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Inhibition of glutathione metabolism attenuates esophageal cancer progression

Peng L, Linghu R, Chen D, Yang J, Kou X, Wang XZ, Hu Y, Jiang YZ, Yang J

Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with regard to mortality and prognosis, and the 5-year survival rate for all patients diagnosed with ESCC remains poor. A better...
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High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients

Cho SY, Park C, Na D, Han JY, Lee J, Park OK, Zhang C, Sung CO, Moon HE, Kim Y, Kim JH, Kim JJ, Khang SK, Nam DH, Choi JW, Suh YL, Kim DG, Park SH, Youn H, Yun K, Kim JI, Lee C, Paek SH, Park H

Gliosarcoma (GS) is a rare variant (2%) of glioblastoma (GBM) that poses clinical genomic challenges because of its poor prognosis and limited genomic information. To gain a comprehensive view of...
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The microbiome of the lung and its extracellular vesicles in nonsmokers, healthy smokers and COPD patients

Kim HJ, Kim YS, Kim KH, Choi JP, Kim YK, Yun S, Sharma L, Dela Cruz , Lee JS, Oh YM, Lee SD, Lee SW

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease, and bacterial infection plays a role in its pathogenesis. Bacteria secrete nanometer-sized extracellular vesicles (EVs), which may induce more immune...
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Transcriptional regulatory networks underlying the reprogramming of spermatogonial stem cells to multipotent stem cells

Jeong HS, Bhin J, Kim HJ, Hwang D, Lee DR, Kim KS

Spermatogonial stem cells (SSCs) are germline stem cells located along the basement membrane of seminiferous tubules in testes. Recently, SSCs were shown to be reprogrammed into multipotent SSCs (mSSCs). However,...
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Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification

Jung BC, Lim YJ, Bae EJ, Lee JS, Choi MS, Lee MK, Lee HJ, Kim YS, Lee SJ

Amyloid fibril formation has been implicated in the pathogenesis of neurodegenerative diseases. Fibrillation generates numerous conformers. Presumably, the conformers may possess specific biological properties, thus providing a biochemical framework for...
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miR-24-mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway

Jeong JH, Cheol Kang Y, Piao Y, Kang S, Pak YK

Mitochondrial deficits or altered expressions of microRNAs are associated with the pathogenesis of various diseases, and microRNA-operated control of mitochondrial activity has been reported. Using a retrovirus-mediated short-hairpin RNA (shRNA)...
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Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic

Jin P, Yin F, Huang L, Zheng L, Zhao J, Zhang X

Neuro-osteological interactions have an important role in the regulation of bone metabolism and regeneration. Neuropeptides combined with porous biphasic calcium phosphates (BCP) using protein adsorption may contribute to the acceleration...
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