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CTHRC1 promotes angiogenesis by recruiting Tie2-expressing monocytes to pancreatic tumors

Lee J, Song J, Kwon ES, Jo S, Kang MK, Kim YJ, Hwang Y, Bae H, Kang TH, Chang S, Cho HJ, Kim SC, Kim S, Koh SS

CTHRC1 (collagen triple-helix repeat-containing 1), a protein secreted during the tissue-repair process, is highly expressed in several malignant tumors, including pancreatic cancer. We recently showed that CTHRC1 has an important...
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ERK-mediated phosphorylation of BIS regulates nuclear translocation of HSF1 under oxidative stress

Kim HY, Kim YS, Yun HH, Im CN, Ko JH, Lee JH

B-cell lymphoma (BCL)-2-interacting cell death suppressor (BIS) has diverse cellular functions depending on its binding partners. However, little is known about the effects of biochemical modification of BIS on its...
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Adenovirus-mediated Foxp3 expression in lung epithelial cells reduces airway inflammation in ovalbumin and cockroach-induced asthma model

Park S, Chung HS, Shin D, Jung KH, Lee H, Moon J, Bae H

Foxp3 is a master regulator of CD4⁺CD25⁺ regulatory T-cell (Treg) function and is also a suppressor of SKP2 and HER2/ErbB2. There are an increasing number of reports describing the functions...
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MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis

Chanda D, Li J, Oligschlaeger Y, Jeurissen , Houben T, Walenbergh SMA, Shiri-Sverdlov R, Neumann D

Non-alcoholic steatohepatitis (NASH), a metabolic disorder consisting of steatosis and inflammation, is considered the hepatic equivalent of metabolic syndrome and can result in irreversible liver damage. Macrophage-stimulating protein (MSP) is...
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Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signaling

Sondag GR, Mbimba TS, Moussa FM, Novak K, Yu B, Jaber FA, Abdelmagid SM, Geldenhuys WJ, Safadi FF

Osteoactivin is a heavily glycosylated protein shown to have a role in bone remodeling. Previous studies from our lab have shown that mutation in Osteoactivin enhances osteoclast differentiation but inhibits...
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Smad4 controls bone homeostasis through regulation of osteoblast/osteocyte viability

Moon YJ, Yun CY, Choi H, Ka SO, Kim JR, Park BH, Cho ES

Regulation of osteoblast and osteocyte viability is essential for bone homeostasis. Smad4, a major transducer of bone morphogenetic protein and transforming growth factor-β signaling pathways, regulates apoptosis in various cell...
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