- MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis
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Chanda D, Li J, Oligschlaeger Y, Jeurissen , Houben T, Walenbergh SMA, Shiri-Sverdlov R, Neumann D
- KMID: 2361545
- Exp Mol Med.
- 2016 Sep;48(9):e258.
- doi: 10.1038/emm.2016.79
Non-alcoholic steatohepatitis (NASH), a metabolic disorder consisting of steatosis and inflammation, is considered the hepatic equivalent of metabolic syndrome and can result in irreversible liver damage. Macrophage-stimulating protein (MSP) is... -
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- Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signaling
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Sondag GR, Mbimba TS, Moussa FM, Novak K, Yu B, Jaber FA, Abdelmagid SM, Geldenhuys WJ, Safadi FF
- KMID: 2361544
- Exp Mol Med.
- 2016 Sep;48(9):e257.
- doi: 10.1038/emm.2016.78
Osteoactivin is a heavily glycosylated protein shown to have a role in bone remodeling. Previous studies from our lab have shown that mutation in Osteoactivin enhances osteoclast differentiation but inhibits... -
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- Smad4 controls bone homeostasis through regulation of osteoblast/osteocyte viability
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Moon YJ, Yun CY, Choi H, Ka SO, Kim JR, Park BH, Cho ES
- KMID: 2361543
- Exp Mol Med.
- 2016 Sep;48(9):e256.
- doi: 10.1038/emm.2016.75
Regulation of osteoblast and osteocyte viability is essential for bone homeostasis. Smad4, a major transducer of bone morphogenetic protein and transforming growth factor-β signaling pathways, regulates apoptosis in various cell... -
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- ERK-mediated phosphorylation of BIS regulates nuclear translocation of HSF1 under oxidative stress
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Kim HY, Kim YS, Yun HH, Im CN, Ko JH, Lee JH
- KMID: 2361547
- Exp Mol Med.
- 2016 Sep;48(9):e260.
- doi: 10.1038/emm.2016.84
B-cell lymphoma (BCL)-2-interacting cell death suppressor (BIS) has diverse cellular functions depending on its binding partners. However, little is known about the effects of biochemical modification of BIS on its... -
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- Adenovirus-mediated Foxp3 expression in lung epithelial cells reduces airway inflammation in ovalbumin and cockroach-induced asthma model
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Park S, Chung HS, Shin D, Jung KH, Lee H, Moon J, Bae H
- KMID: 2361546
- Exp Mol Med.
- 2016 Sep;48(9):e259.
- doi: 10.1038/emm.2016.83
Foxp3 is a master regulator of CD4âºCD25⺠regulatory T-cell (Treg) function and is also a suppressor of SKP2 and HER2/ErbB2. There are an increasing number of reports describing the functions... -
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- CTHRC1 promotes angiogenesis by recruiting Tie2-expressing monocytes to pancreatic tumors
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Lee J, Song J, Kwon ES, Jo S, Kang MK, Kim YJ, Hwang Y, Bae H, Kang TH, Chang S, Cho HJ, Kim SC, Kim S, Koh SS
- KMID: 2361548
- Exp Mol Med.
- 2016 Sep;48(9):e261.
- doi: 10.1038/emm.2016.87
CTHRC1 (collagen triple-helix repeat-containing 1), a protein secreted during the tissue-repair process, is highly expressed in several malignant tumors, including pancreatic cancer. We recently showed that CTHRC1 has an important... -
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