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Therapeutic effects of adipose-derived stem cells pretreated with pioglitazone in an emphysema mouse model

Hong Y, Kim YS, Hong SH, Oh YM

There is no therapy currently available that influences the natural history of disease progression in patients with chronic obstructive pulmonary disease (COPD). Although stem cell therapy is considered a potential...
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Genome editing: the road of CRISPR/Cas9 from bench to clinic

Eid A, Mahfouz MM

Molecular scissors engineered for site-specific modification of the genome hold great promise for effective functional analyses of genes, genomes and epigenomes and could improve our understanding of the molecular underpinnings...
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High yields and soluble expression of superoxide dismutases in Escherichia coli due to the HIV-1 Tat peptide via increases in mRNA transcription

Sun Y, Ye Q, Wu M, Wu Y, Zhang C, Yan W

This study aimed to validate the high yield and soluble expression of proteins carrying the transactivator of transcription (Tat) peptide tag, and further explored the potential mechanism by which the...
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Mechanisms of aging-related proteinopathies in Caenorhabditis elegans

Kim DK, Kim TH, Lee SJ

Aging is the most important risk factor for human neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Pathologically, these diseases are characterized by the deposition of specific protein aggregates in...
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A novel anti-IL4Rα nanoparticle efficiently controls lung inflammation during asthma

Halwani R, Sultana Shaik A, Ratemi E, Afzal S, Kenana R, Al-Muhsen , Al Faraj A

Drug resistance and the harmful side effects accompanying the prolonged corticosteroid treatment of chronic pulmonary diseases prompted the development of more specific anti-inflammatory approaches. Several strategies aiming to block IL4Rα,...
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