- Regulation and function of AMPK in physiology and diseases
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Jeon SM
- KMID: 2361532
- Exp Mol Med.
- 2016 Jul;48(7):e245.
- doi: 10.1038/emm.2016.81
5′-adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase that was originally identified as the key player in maintaining cellular energy homeostasis. Intensive research over the last... -
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- Stimulatory versus suppressive effects of GM-CSF on tumor progression in multiple cancer types
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Hong IS
- KMID: 2361529
- Exp Mol Med.
- 2016 Jul;48(7):e242.
- doi: 10.1038/emm.2016.64
Granulocyte-macrophage colony-stimulating factor (GM-CSF, also called CSF-2) is best known for its critical role in immune modulation and hematopoiesis. A large body of experimental evidence indicates that GM-CSF, which is... -
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- Sur8 mediates tumorigenesis and metastasis in colorectal cancer
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Lee YM, Kaduwal S, Lee KH, Park JC, Jeong WJ, Choi KY
- KMID: 2361536
- Exp Mol Med.
- 2016 Jul;48(7):e249.
- doi: 10.1038/emm.2016.58
Sur8, a scaffold protein of the Ras pathway, interacts with Ras and Raf and modulates the Ras-extracellular signal-regulated kinase (ERK) pathway. Here we show that Sur8 is overexpressed in established... -
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- A polymorphic minisatellite region of BORIS regulates gene expression and its rare variants correlate with lung cancer susceptibility
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Yoon SL, Roh YG, Chu IS, Heo J, Kim SI, Chang H, Kang TH, Chung JW, Koh SS, Larionov V, Leem SH
- KMID: 2361533
- Exp Mol Med.
- 2016 Jul;48(7):e246.
- doi: 10.1038/emm.2016.50
Aberrant expression of BORIS/CTCFL (Brother of the Regulator of Imprinted Sites/CTCF-like protein) is reported in different malignancies. In this study, we characterized the entire promoter region of BORIS/CTCFL, including the... -
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- Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson's disease alpha-synuclein transgenic mice
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Ye M, Chung HS, Lee C, Song JH, Shim I, Kim YS, Bae H
- KMID: 2361531
- Exp Mol Med.
- 2016 Jul;48(7):e244.
- doi: 10.1038/emm.2016.49
α-Synuclein (α-Syn) has a critical role in microglia-mediated neuroinflammation, which leads to the development of Parkinson's disease (PD). Recent studies have shown that bee venom (BV) has beneficial effects on... -
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- The role of autophagy in allergic inflammation: a new target for severe asthma
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Liu JN, Suh DH, Trinh HK, Chwae YJ, Park HS, Shin YS
- KMID: 2361530
- Exp Mol Med.
- 2016 Jul;48(7):e243.
- doi: 10.1038/emm.2016.38
Autophagy has been investigated for its involvement in inflammatory diseases, but its role in asthma has been little studied. This study aimed to explore the possible role of autophagy and... -
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- miR-30c regulates proliferation, apoptosis and differentiation via the Shh signaling pathway in P19 cells
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Liu X, Li M, Peng Y, Hu X, Xu J, Zhu S, Yu Z, Han S
- KMID: 2361535
- Exp Mol Med.
- 2016 Jul;48(7):e248.
- doi: 10.1038/emm.2016.57
MicroRNAs (miRNAs) are small, non-coding single-stranded RNAs that suppress protein expression by binding to the 3′ untranslated regions of their target genes. Many studies have shown that miRNAs have important... -
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- Genetic–pathologic characterization of myeloproliferative neoplasms
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Kim Y, Park J, Jo I, Lee GD, Kim J, Kwon A, Choi H, Jang W, Chae H, Han K, Eom KS, Cho BS, Lee SE, Yang J, Shin SH, Kim H, Ko YH, Park H, Jin JY, Lee S, Jekarl DW, Yahng SA, Kim M
- KMID: 2361534
- Exp Mol Med.
- 2016 Jul;48(7):e247.
- doi: 10.1038/emm.2016.55
Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by the proliferation of one or more myeloid lineages. The current study demonstrates that three driver mutations were detected in... -
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